BIDMC Endocrinology Virtual Grand Rounds
October 15th, 2021 (9:00AM-10:00AM)
Auryan Szalat, MD
Senior Lecturer in Internal Medicine
Internal Medicine Ward
Endocrinology and Metabolic Disease Service
Director of the Osteoporosis Center
Hadassah Medical Center, Mount Scopus
“Oral PTH (1-34): A new potential treatment for patients with hypoparathyroidism (published and unpublished data)”
Conventional therapy in Hypoparathyroid patients does not address the lack of PTH hormone, and thus can not restore the physiologic calcium-phosphore homeostasis.
Hypoparathyroid patients continue to suffer from hyperphosphatemia, hypercalciuria, difficulty to stabilize blood calcium levels and report diminished quality of life.
in 2015, subcutaneous (SC) PTH 1-84 was approved by the FDA for refractory hypoparathyroidism, and showed improvement in the main parameters of the disease.
An alternative to the SC PTH 1-84, namely an oral formulation of oral PTH 1-34, elaborated thanks to a unique synergistic platform (protection from gastric lysis and enhanced intestinal absorption) to pass the gastro-intestinal barrier, was evaluated regarding safety and efficacy in a pilot phase 2a study which included 19 patients with hypoparathyroidism.
The results of the study and the future of this oral preparation will be described.
Please email CSRmail@partners.org for the Zoom Meeting information
Jennifer Lee, PhD
Partha Sinha, MD
Contact Louise McHale at (617) 735-3322 with any questions.
1) Fellows, physicians, professors, researchers, graduate and medical students;
2) Endocrinologists, Diabetologists; and basic researchers in these fields; and
3) HMS-affiliated hospitals/institutions and other area facilities
Upon completion of this activity, participants will be able to:
- Outline the current research developments in Diabetes, Obesity, Metabolism, Bone, Thyroid
and other Endocrine disorders;
- Analyze clinical research developments as they relate to current Endocrinology practice issues;
- Outline the recommendations given by recent clinical practice guidelines; and
- Apply the lessons learned from clinical update and clinical practice guidelines to future clinical practice.
The Harvard Medical School is accredited by the Accreditation Council for
Continuing Medical Education to provide continuing medical education for physicians.