The Carl J. Shapiro Department of Orthopaedic Surgery invites you to the Wilson C. Hayes Distinguished Lecture Series on Musculoskeletal Heath on April 3, 2024, at 8 AM EST. Attached, please find the lecture flyer.
Functional Biomaterials for Tissue Regeneration
Treena Livingston Arinzeh, PhD
Professor of Biomedical Engineering
Director of the Tissue Engineering and Active bioMaterials (TEAM) Laboratory
Columbia University, New York
Advances in biomaterial design and its impact on biological function has shown promise in the field of regenerative medicine. This presentation will describe biomaterial properties and designs that impart cues to stem cells and other cell types to affect their behavior and tissue formation in vitro and in vivo. The design of functional, bioinspired materials to be used alone to recruit endogenous cells for tissue repair will also be discussed. Our recent work utilizes protein-based biomaterials as a metabolic approach for bone tissue repair, where studies demonstrate an effect on stem cell migration and differentiation. In combination with a gene knockout model, we are learning about the role of glutamine, which becomes available upon biomaterial degradation, and its effect on bone repair. We have also developed novel glycosaminoglycan (GAG) mimetics, which are sulfated polysaccharides that vary in their degree of sulfation and can be combined to form polymer blends to create scaffolds. Studies demonstrate their sequestration of growth factors and their effect on cartilage repair. ECM proteins, such as collagen and elastin, exhibit electromechanical behavior. Our work using piezoelectric materials, which are materials that provide electrical activity in response to mechanical stimuli, have been explored in in vitro and in vivo models with recent work using degradable, piezoelectric materials having tunable properties. These biomaterials and their potential use in orthopaedic and neural applications will be discussed.
Email CSRmail@partners.org for Zoom information