Publications

Publications supported by the Center for Musculoskeletal Research

2024 PUBLICATIONS
Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants

Liu, S., Daley, E. J., Tran, L. M., Yu, Z., Reyes, M., Dean, T., Khatri, A., Levine, P. M., Balana, A. T., Pratt, M. R., Jüppner, H., Gellman, S. H., & Gardella, T. J. (2024). Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants. Journal of the American Chemical Society, 146(10), 6522–6529. https://doi.org/10.1021/jacs.3c09694
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome

Portales-Castillo, I., Dean, T., Cheloha, R. W., Creemer, B. A., Vilardaga, J. P., Savransky, S., Khatri, A., Jüppner, H., & Gardella, T. J. (2023). Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome. Communications biology, 6(1), 599. https://doi.org/10.1038/s42003-023-04966-0

EARLIER PUBLICATIONS
Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling

Yadav PS, Kobelski MM, Martins JS, Tao T, Liu ES, Demay MB. Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling. Endocrinology. 2023;165(1):bqad186. DOI: 10.1210/endocr/bqad186
Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes

Yadav PS, Papaioannou G, Kobelski MM, Demay MB. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. iScience. 2023;26(9):107548. Published 2023 Aug 7. doi:10.1016/j.isci.2023.107548
Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation.

Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Bone Rep. 2023 Jan 23;18:101657. doi: 10.1016/j.bonr.2023.101657. PMID: 37425193; PMCID: PMC10323218.
Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome

Portales-Castillo I, Dean T, Cheloha RW, Creemer BA, Vilardaga JP, Savransky S, Khatri A, Jüppner H, Gardella TJ. . Commun Biol. 2023 Jun 2;6(1):599. doi: 10.1038/s42003-023-04966-0. PMID: 37268817; PMCID: PMC10238420.
Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression.

Young C, Kobayashi T.  Osteoarthritis Cartilage. 2023 Jun;31(6):775-779. doi: 10.1016/j.joca.2023.01.576. Epub 2023 Feb 17. PMID: 36805475

Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study.

Mitchell DM, Singhal V, Animashaun A, Bose A, Carmine B, Stanford FC, Inge TH, Kelsey MM, Lee H, Bouxsein ML, Yu EW, Bredella MA, Misra M. J Clin Endocrinol Metab. 2023 Mar 10;108(4):847-857. doi: 10.1210/clinem/dgac634. PMID: 36314507; PMCID: PMC10211497.
Protectin DX as a therapeutic strategy against frailty in mice. 

Perazza LR, Gower AC, Brown-Borg HM, Pajevic PD, Thompson LV. Geroscience. 2023 Apr 14. doi: 10.1007/s11357-023-00789-3. Online ahead of print. PMID: 37059838
Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls. 

Singhal V, Kaur S, Haidar LA, Lee H, Bredella MA, Misra M. Bone. 2023 Apr 6;172:116757. doi: 10.1016/j.bone.2023.116757. Online ahead of print. PMID: 37030498
Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study. 

Mitchell DM, Singhal V, Animashaun A, Bose A, Carmine B, Stanford FC, Inge TH, Kelsey MM, Lee H, Bouxsein ML, Yu EW, Bredella MA, Misra M. J Clin Endocrinol Metab. 2023 Mar 10;108(4):847-857. doi: 10.1210/clinem/dgac634. PMID: 36314507
Endogenous Tenocyte Activation Underlies the Regenerative Capacity of Adult Zebrafish Tendon. 

Tsai SL, Villasenor S, Shah R, Galloway JL. bioRxiv. 2023 Feb 4:2023.02.04.527141. doi: 10.1101/2023.02.04.527141. Preprint. PMID: 36778338 Free PMC article.
The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass. 

Zahedi B, Daley EJ, Brooks DJ, Bruce M, Townsend RL, Berthoud HR, Bouxsein ML, Yu EW. Bone. 2023 Feb;167:116608. doi: 10.1016/j.bone.2022.116608. Epub 2022 Nov 8. PMID: 36368466
WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects. 

Oh WT, Yang YS, Xie J, Ma H, Kim JM, Park KH, Oh DS, Park-Min KH, Greenblatt MB, Gao G, Shim JH. Mol Ther. 2023 Feb 1;31(2):435-453. doi: 10.1016/j.ymthe.2022.09.018. Epub 2022 Oct 3. PMID: 36184851
Testican-2 Is Associated with Reduced Risk of Incident ESKD. 

Wen D, Zhou L, Zheng Z, Surapaneni A, Ballantyne CM, Hoogeveen RC, Shlipak MG, Waikar SS, Vasan RS, Kimmel PL, Dubin RF, Deo R, Feldman HI, Ganz P, Coresh J, Grams ME, Rhee EP; CKD Biomarkers Consortium. J Am Soc Nephrol. 2023 Jan 1;34(1):122-131. doi: 10.1681/ASN.2022020216. Epub 2022 Oct 26. PMID: 36288905
Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice. 

Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U, Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2214396119. doi: 10.1073/pnas.2214396119. Epub 2022 Dec 6. PMID: 36472957 Free PMC article.
Denosumab versus intravenous bisphosphonate use for hypercalcemia in multiple myeloma. 

Lei MM, Tavares E, Buzgo E, Lou U, Raje N, Yee AJ. Leuk Lymphoma. 2022 Dec;63(13):3249-3252. doi: 10.1080/10428194.2022.2115840. Epub 2022 Aug 29. PMID: 36036363 No abstract available.
Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration. 

Lin C, Yang Q, Guo D, Xie J, Yang YS, Chaugule S, DeSouza N, Oh WT, Li R, Chen Z, John AA, Qiu Q, Zhu LJ, Greenblatt MB, Ghosh S, Li S, Gao G, Haynes C, Emerson CP, Shim JH. Nat Commun. 2022 Nov 11;13(1):6869. doi: 10.1038/s41467-022-34694-8. PMID: 36369293 Free PMC article.
Denosumab increases spine bone density in women with anorexia nervosa: a randomized clinical trial. 

Haines MS, Kimball A, Meenaghan E, Santoso K, Colling C, Singhal V, Ebrahimi S, Gleysteen S, Schneider M, Ciotti L, Belfer P, Eddy KT, Misra M, Miller KK. Eur J Endocrinol. 2022 Oct 13;187(5):697-708. doi: 10.1530/EJE-22-0248. Print 2022 Nov 1. PMID: 36134902 Clinical Trial.
Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Male C57BL/6J Mice. 

Carvalho AL, Brooks DJ, Barlow D, Langlais AL, Morrill B, Houseknecht KL, Bouxsein ML, Lian JB, King T, Farina NH, Motyl KJ. J Bone Miner Res. 2022 Nov;37(11):2226-2243. doi: 10.1002/jbmr.4690. Epub 2022 Sep 26. PMID: 36054037
Load-to-strength ratio at the radius is higher in adolescent and young adult females with obesity compared to normal-weight controls. 

Singhal V, Huynh C, Nimmala S, Mitchell DM, Pedreira CC, Bader A, Flanders K, Zheng J, Bouxsein ML, Misra M, Bredella MA. Bone. 2022 Nov;164:116515. doi: 10.1016/j.bone.2022.116515. Epub 2022 Aug 7. PMID: 35948256
Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis. 

Shaw AT, Yan J, Kuhstoss SA, Charles JF, Gravallese EM. Scand J Rheumatol. 2022 Nov;51(6):495-499. doi: 10.1080/03009742.2022.2040136. Epub 2022 Mar 11. PMID: 35272576
Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study. 

Wen D, Zheng Z, Surapaneni A, Yu B, Zhou L, Zhou W, Xie D, Shou H, Avila-Pacheco J, Kalim S, He J, Hsu CY, Parsa A, Rao P, Sondheimer J, Townsend R, Waikar SS, Rebholz CM, Denburg MR, Kimmel PL, Vasan RS, Clish CB, Coresh J, Feldman HI, Grams ME, Rhee EP; CKD Biomarkers Consortium and CRIC Study Investigators. JCI Insight. 2022 Oct 24;7(20):e161696. doi: 10.1172/jci.insight.161696. PMID: 36048534 Free PMC article.
Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery. 

Yang YS, Kim JM, Xie J, Chaugule S, Lin C, Ma H, Hsiao E, Hong J, Chun H, Shore EM, Kaplan FS, Gao G, Shim JH. Nat Commun. 2022 Oct 19;13(1):6175. doi: 10.1038/s41467-022-33956-9. PMID: 36258013 Free PMC article.
PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond. 

Portales-Castillo I, Simic P. Front Endocrinol (Lausanne). 2022 Sep 29;13:992666. doi: 10.3389/fendo.2022.992666. eCollection 2022. PMID: 36246903 Free PMC article. Review.
Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy. 

Mazur CM, Castro Andrade CD, Tokavanich N, Sato T, Bruce M, Brooks DJ, Bouxsein ML, Wang JS, Wein MN. iScience. 2022 Aug 27;25(9):105019. doi: 10.1016/j.isci.2022.105019. eCollection 2022 Sep 16. PMID: 36105586 Free PMC article.
AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy. 

John AA, Xie J, Yang YS, Kim JM, Lin C, Ma H, Gao G, Shim JH. Mol Ther Nucleic Acids. 2022 Jul 11;29:296-311. doi: 10.1016/j.omtn.2022.07.008. eCollection 2022 Sep 13. PMID: 35950212 Free PMC article.
Changes in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters. 

Nimmala S, Kaur S, Singhal V, Mitchell DM, Stanford FC, Bouxsein ML, Lauze M, Huynh C, Pedreira CC, Lee H, Bredella MA, Misra M. J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3747-e3758. doi: 10.1210/clinem/dgac361. PMID: 35689793
Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway. 

Kim JM, Yang YS, Hong J, Chaugule S, Chun H, van der Meulen MCH, Xu R, Greenblatt MB, Shim JH. Elife. 2022 Aug 17;11:e78069. doi: 10.7554/eLife.78069. PMID: 35975983 Free PMC article.
A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4. 

Phan HTN, Loomis J, Abraham S, He Q, Bastepe M, Smrcka AV. J Biol Chem. 2022 Aug;298(8):102134. doi: 10.1016/j.jbc.2022.102134. Epub 2022 Jun 13. PMID: 35709985 Free PMC article.
CGRP and Shh Mediate the Dental Pulp Cell Response to Neuron Stimulation. 

Moore ER, Michot B, Erdogan O, Ba A, Gibbs JL, Yang Y. J Dent Res. 2022 Aug;101(9):1119-1126. doi: 10.1177/00220345221086858. Epub 2022 Apr 11. PMID: 35403480
Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes. 

Kim JM, Yang YS, Xie J, Lee O, Kim J, Hong J, Boldyreff B, Filhol O, Chun H, Greenblatt MB, Gao G, Shim JH. Cell Death Differ. 2022 Aug;29(8):1625-1638. doi: 10.1038/s41418-022-00952-x. Epub 2022 Feb 15. PMID: 35169297
Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice. 

Daley EJ, Yoon SH, Reyes M, Bruce M, Brooks DJ, Bouxsein M, Potts JT, Kronenberg HM, Wein MN, Lanske B, Jüppner H, Gardella TJ. Endocrinology. 2022 Jul 1;163(7):bqac054. doi: 10.1210/endocr/bqac054. PMID: 35460406 Free PMC article.
Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes. 

Bell N, Bhagat S, Muruganandan S, Kim R, Ho K, Pierce R, Kozhemyakina E, Lassar AB, Gamer L, Rosen V, Ionescu AM. Bone. 2022 Jul;160:116418. doi: 10.1016/j.bone.2022.116418. Epub 2022 Apr 6. PMID: 35398294
Physiologic Transdermal Estradiol Replacement Mimics Effects of Endogenous Estrogen on Bone Outcomes in Hypoestrogenic Women with Anorexia Nervosa. 

Singhal V, Nimmala S, Slattery M, Eddy KT, Miller KK, Klibanski A, Misra M. Nutrients. 2022 Jun 21;14(13):2557. doi: 10.3390/nu14132557. PMID: 35807738 Free PMC article.
A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury. 

Muruganandan S, Pierce R, Teguh DA, Perez RF, Bell N, Nguyen B, Hohl K, Snyder BD, Grinstaff MW, Alberico H, Woods D, Kong Y, Sima C, Bhagat S, Ho K, Rosen V, Gamer L, Ionescu AM. Nat Commun. 2022 May 6;13(1):2515. doi: 10.1038/s41467-022-30247-1. PMID: 35523895 Free PMC article.
Propranolol Promotes Bone Formation and Limits Resorption Through Novel Mechanisms During Anabolic Parathyroid Hormone Treatment in Female C57BL/6J Mice. 

Treyball A, Bergeron AC, Brooks DJ, Langlais AL, Hashmi H, Nagano K, Barlow D, Neilson RJ, Roy TA, Nevola KT, Houseknecht KL, Baron R, Bouxsein ML, Guntur AR, Motyl KJ. J Bone Miner Res. 2022 May;37(5):954-971. doi: 10.1002/jbmr.4523. Epub 2022 Mar 10. PMID: 35122666 Free PMC article.
Impact of GH administration on skeletal endpoints in adults with overweight/obesity. 

Dichtel LE, Haines MS, Gerweck AV, Bollinger B, Kimball A, Schoenfeld D, Bredella MA, Miller KK. Eur J Endocrinol. 2022 Apr 21;186(6):619-629. doi: 10.1530/EJE-21-1061. PMID: 35315344 Free PMC article. Clinical Trial.
Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb. 

Maridas DE, Gamer L, Moore ER, Doedens AM, Yu Y, Ionescu A, Revollo L, Whitman M, Rosen V. J Bone Miner Res. 2022 Apr;37(4):764-775. doi: 10.1002/jbmr.4514. Epub 2022 Feb 16. PMID: 35080046
Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling. 

Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, Gutierrez O, Babitt JL, Jung G, Salusky IB, Hanudel M, Faul C. Elife. 2022 Mar 18;11:e74782. doi: 10.7554/eLife.74782. PMID: 35302487 Free PMC article.
Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins. 

Panaroni C, Fulzele K, Mori T, Siu KT, Onyewadume C, Maebius A, Raje N. Blood. 2022 Feb 10;139(6):876-888. doi: 10.1182/blood.2021013832. PMID: 34662370 Free PMC article.
Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use. 

Khedgikar V, Charles JF, Lehoczky JA. Bone. 2022 Feb;155:116267. doi: 10.1016/j.bone.2021.116267. Epub 2021 Nov 29. PMID: 34856421
The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation. 

Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R. Blood. 2022 Jan 6;139(1):104-117. doi: 10.1182/blood.2020010342. PMID: 34329392 Free PMC article.
Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease. 

Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP, Naxerova K, Swirski FK, Nahrendorf M. Nat Cardiovasc Res. 2022 Jan;1(1):28-44. doi: 10.1038/s44161-021-00002-8. Epub 2021 Dec 23. PMID: 35747128 Free PMC article.
Age-Related Changes in Bone Density, Microarchitecture, and Strength in Postmenopausal Black and White Women: The SWAN Longitudinal HR-pQCT Study. 

Johannesdottir F, Putman MS, Burnett-Bowie SM, Finkelstein JS, Yu EW, Bouxsein ML.

J Bone Miner Res. 2022 Jan;37(1):41-51. doi: 10.1002/jbmr.4460. Epub 2021 Nov 9.

PMID: 34647644 Free PMC article.
The effect of short-term high-caloric feeding and fasting on bone microarchitecture. 

Bredella MA, Fazeli PK, Bourassa J, Rosen CJ, Bouxsein ML, Klibanski A, Miller KK.

Bone. 2022 Jan;154:116214. doi: 10.1016/j.bone.2021.116214. Epub 2021 Sep 25.

PMID: 34571202 Free PMC article.
Fibroblast Growth Factor 23 Regulation and Acute Kidney Injury. 

Zhou W, Simic P, Rhee EP.

Nephron. 2022;146(3):239-242. doi: 10.1159/000517734. Epub 2021 Jul 20.

PMID: 34284404 Free PMC article. Review.
Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss. 

Uda Y, Saini V, Petty CA, Alshehri M, Shi C, Spatz JM, Santos R, Newell CM, Huang TY, Kochen A, Kim JW, Constantinou CK, Saito H, Held KD, Hesse E, Pajevic PD.

Aging (Albany NY). 2021 Dec 30;13(24):25607-25642. doi: 10.18632/aging.203808. Epub 2021 Dec 30.

PMID: 34968192 Free PMC article.
Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis. 

Kim PG, Niroula A, Shkolnik V, McConkey M, Lin AE, Słabicki M, Kemp JP, Bick A, Gibson CJ, Griffin G, Sekar A, Brooks DJ, Wong WJ, Cohen DN, Uddin MM, Shin WJ, Pirruccello J, Tsai JM, Agrawal M, Kiel DP, Bouxsein ML, Richards JB, Evans DM, Wein MN, Charles JF, Jaiswal S, Natarajan P, Ebert BL.

J Exp Med. 2021 Dec 6;218(12):e20211872. doi: 10.1084/jem.20211872. Epub 2021 Oct 26.

PMID: 34698806 Free PMC article.
Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. 

Mori T, Verma R, Nakamoto-Matsubara R, Siu KT, Panaroni C, Fulzele KS, Mukaihara K, Onyewadume C, Maebius A, Kato H, Wong LP, Sadreyev RI, Scadden DT, Raje NS.

Blood Cancer J. 2021 Dec 4;11(12):194. doi: 10.1038/s41408-021-00589-y.

PMID: 34864816 Free PMC article.
tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche. 

Kfoury YS, Ji F, Mazzola M, Sykes DB, Scherer AK, Anselmo A, Akiyama Y, Mercier F, Severe N, Kokkaliaris KD, Zhao T, Brouse T, Saez B, Seidl J, Papazian A, Ivanov P, Mansour MK, Sadreyev RI, Scadden DT.

Cell Stem Cell. 2021 Dec 2;28(12):2090-2103.e9. doi: 10.1016/j.stem.2021.08.014. Epub 2021 Sep 21.

PMID: 34551362 Free PMC article.
Regulation of FGF23: Beyond Bone. 

Simic P, Babitt JL.

Curr Osteoporos Rep. 2021 Dec;19(6):563-573. doi: 10.1007/s11914-021-00703-w. Epub 2021 Nov 10.

PMID: 34757587 Free PMC article. Review.
Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma. 

Waldschmidt JM, Kloeber JA, Anand P, Frede J, Kokkalis A, Dimitrova V, Potdar S, Nair MS, Vijaykumar T, Im NG, Guillaumet-Adkins A, Chopra N, Stuart H, Budano L, Sotudeh N, Guo G, Grassberger C, Yee AJ, Laubach JP, Richardson PG, Anderson KC, Raje NS, Knoechel B, Lohr JG.

Clin Cancer Res. 2021 Dec 1;27(23):6432-6444. doi: 10.1158/1078-0432.CCR-21-2040. Epub 2021 Sep 13.

PMID: 34518309 Free PMC article.
Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height. 

Renthal NE, Nakka P, Baronas JM, Kronenberg HM, Hirschhorn JN.

J Bone Miner Res. 2021 Dec;36(12):2300-2308. doi: 10.1002/jbmr.4408. Epub 2021 Aug 3.

PMID: 34346115
Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment. 

Kfoury Y, Baryawno N, Severe N, Mei S, Gustafsson K, Hirz T, Brouse T, Scadden EW, Igolkina AA, Kokkaliaris K, Choi BD, Barkas N, Randolph MA, Shin JH, Saylor PJ, Scadden DT, Sykes DB, Kharchenko PV; as part of the Boston Bone Metastases Consortium.

Cancer Cell. 2021 Nov 8;39(11):1464-1478.e8. doi: 10.1016/j.ccell.2021.09.005. Epub 2021 Oct 15.

PMID: 34719426 Free PMC article.
Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin. 

Wang JS, Kamath T, Mazur CM, Mirzamohammadi F, Rotter D, Hojo H, Castro CD, Tokavanich N, Patel R, Govea N, Enishi T, Wu Y, da Silva Martins J, Bruce M, Brooks DJ, Bouxsein ML, Tokarz D, Lin CP, Abdul A, Macosko EZ, Fiscaletti M, Munns CF, Ryder P, Kost-Alimova M, Byrne P, Cimini B, Fujiwara M, Kronenberg HM, Wein MN.

Nat Commun. 2021 Nov 1;12(1):6271. doi: 10.1038/s41467-021-26571-7.

PMID: 34725346 Free PMC article.
Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma. 

Frede J, Anand P, Sotudeh N, Pinto RA, Nair MS, Stuart H, Yee AJ, Vijaykumar T, Waldschmidt JM, Potdar S, Kloeber JA, Kokkalis A, Dimitrova V, Mann M, Laubach JP, Richardson PG, Anderson KC, Raje NS, Knoechel B, Lohr JG.

Nat Cell Biol. 2021 Nov;23(11):1199-1211. doi: 10.1038/s41556-021-00766-y. Epub 2021 Oct 21.

PMID: 34675390 Free PMC article.
Sequential Therapy With Recombinant Human IGF-1 Followed by Risedronate Increases Spine Bone Mineral Density in Women With Anorexia Nervosa: A Randomized, Placebo-Controlled Trial. 

Haines MS, Kimball A, Meenaghan E, Bachmann KN, Santoso K, Eddy KT, Singhal V, Ebrahimi S, Dechant E, Weigel T, Ciotti L, Keane RJ, Gleysteen S, Mickley D, Bredella MA, Tan CO, Gupta R, Misra M, Schoenfeld D, Klibanski A, Miller KK.

J Bone Miner Res. 2021 Nov;36(11):2116-2126. doi: 10.1002/jbmr.4420. Epub 2021 Sep 2.

PMID: 34355814 Free PMC article. Clinical Trial.
Bone marrow adipose tissue composition following high-caloric feeding and fasting. 

Bredella MA, Buckless C, Fazeli PK, Rosen CJ, Torriani M, Klibanski A, Miller KK.

Bone. 2021 Nov;152:116093. doi: 10.1016/j.bone.2021.116093. Epub 2021 Jun 27.

PMID: 34186250 Free PMC article.
Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation. 

White AD, Peña KA, Clark LJ, Maria CS, Liu S, Jean-Alphonse FG, Lee JY, Lei S, Cheng Z, Tu CL, Fang F, Szeto N, Gardella TJ, Xiao K, Gellman SH, Bahar I, Sutkeviciute I, Chang W, Vilardaga JP.

Sci Signal. 2021 Oct 5;14(703):eabc5944. doi: 10.1126/scisignal.abc5944. Epub 2021 Oct 5.

PMID: 34609896 Free PMC article.
Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease. 

Courbon G, Francis C, Gerber C, Neuburg S, Wang X, Lynch E, Isakova T, Babitt JL, Wolf M, Martin A, David V.

Bone Res. 2021 Aug 2;9(1):35. doi: 10.1038/s41413-021-00154-0.

PMID: 34334787 Free PMC article.
Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice. 

Ko FC, Kobelski MM, Zhang W, Grenga GM, Martins JS, Demay MB.

J Bone Miner Res. 2021 Aug;36(8):1510-1520. doi: 10.1002/jbmr.4312. Epub 2021 Jun 4.

PMID: 33900666
Joint disease-specificity at the regulatory base-pair level. 

Muthuirulan P, Zhao D, Young M, Richard D, Liu Z, Emami A, Portilla G, Hosseinzadeh S, Cao J, Maridas D, Sedlak M, Menghini D, Cheng L, Li L, Ding X, Ding Y, Rosen V, Kiapour AM, Capellini TD.

Nat Commun. 2021 Jul 6;12(1):4161. doi: 10.1038/s41467-021-24345-9.

PMID: 34230488 Free PMC article.
Glycerol-3-phosphate and fibroblast growth factor 23 regulation. 

Simic P, Babitt JL, Rhee EP.

Curr Opin Nephrol Hypertens. 2021 Jul 1;30(4):397-403. doi: 10.1097/MNH.0000000000000715.

PMID: 33901058 Free PMC article. Review.
Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling. 

Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y.

Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118. doi: 10.1073/pnas.2020100118.

PMID: 34172578 Free PMC article.
A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification. 

Cong Q, Liu Y, Zhou T, Zhou Y, Xu R, Cheng C, Chung HS, Yan M, Zhou H, Liao Z, Gao B, Bocobo GA, Covington TA, Song HJ, Su P, Yu PB, Yang Y.

Sci Transl Med. 2021 Jun 23;13(599):eabb2233. doi: 10.1126/scitranslmed.abb2233.

PMID: 34162750 Free PMC article.
Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption. 

Tang CC, Castro Andrade CD, O’Meara MJ, Yoon SH, Sato T, Brooks DJ, Bouxsein ML, Martins JDS, Wang J, Gray NS, Misof B, Roschger P, Blouin S, Klaushofer K, Velduis-Vlug A, Vegting Y, Rosen CJ, O’Connell D, Sundberg TB, Xavier RJ, Ung P, Schlessinger A, Kronenberg HM, Berdeaux R, Foretz M, Wein MN.

Elife. 2021 Jun 23;10:e67772. doi: 10.7554/eLife.67772.

PMID: 34160349 Free PMC article.
The dynamics of human bone marrow adipose tissue in response to feeding and fasting. 

Fazeli PK, Bredella MA, Pachon-Peña G, Zhao W, Zhang X, Faje AT, Resulaj M, Polineni SP, Holmes TM, Lee H, O’Donnell EK, MacDougald OA, Horowitz MC, Rosen CJ, Klibanski A.

JCI Insight. 2021 Jun 22;6(12):e138636. doi: 10.1172/jci.insight.138636.

PMID: 33974568 Free PMC article.
Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa. 

Singhal V, Bose A, Slattery M, Haines MS, Goldstein MA, Gupta N, Brigham KS, Ebrahimi S, Javaras KN, Bouxsein ML, Eddy KT, Miller KK, Schoenfeld D, Klibanski A, Misra M.

J Clin Endocrinol Metab. 2021 Jun 16;106(7):2021-2035. doi: 10.1210/clinem/dgab145.

PMID: 33693703 Free PMC article. Clinical Trial.
Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH. 

Yuan Y, Jagga S, Martins JS, Rana R, Pajevic PD, Liu ES.

PLoS One. 2021 May 27;16(5):e0252348. doi: 10.1371/journal.pone.0252348. eCollection 2021.

PMID: 34043707 Free PMC article.
The impact of genetic background and sex on the phenotype of IL-23 induced murine spondyloarthritis. 

Haley EK, Matmusaev M, Hossain IN, Davin S, Martin TM, Ermann J.

PLoS One. 2021 May 13;16(5):e0247149. doi: 10.1371/journal.pone.0247149. eCollection 2021.

PMID: 33983951 Free PMC article.
Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH. 

Sato T, Verma S, Khatri A, Dean T, Goransson O, Gardella TJ, Wein MN.

JBMR Plus. 2021 May 6;5(5):e10441. doi: 10.1002/jbm4.10441. eCollection 2021 May.

PMID: 33977197 Free PMC article.
Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea. 

Singhal V, Karzar NH, Bose A, Buckless C, Ackerman KE, Bredella MA, Klibanski A, Misra M.

Bone. 2021 Apr;145:115841. doi: 10.1016/j.bone.2021.115841. Epub 2021 Jan 6.

PMID: 33418100 Free PMC article.
Sclerostin Antibody Administration Increases the Numbers of Sox9creER+ Skeletal Precursors and Their Progeny. 

Balani DH, Trinh S, Xu M, Kronenberg HM.

J Bone Miner Res. 2021 Apr;36(4):757-767. doi: 10.1002/jbmr.4238. Epub 2021 Jan 23.

PMID: 33400836 Free PMC article.
Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes. 

Fairfield H, Costa S, Falank C, Farrell M, Murphy CS, D’Amico A, Driscoll H, Reagan MR.

Front Oncol. 2021 Feb 18;10:584683. doi: 10.3389/fonc.2020.584683. eCollection 2020.

PMID: 33680918 Free PMC article.
Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues. 

Daley EJ, Khatri A, Dean T, Vilardaga JP, Zaidi SA, Katritch V, Gardella TJ.

Endocrinology. 2021 Feb 1;162(2):bqaa216. doi: 10.1210/endocr/bqaa216.

PMID: 33242090 Free PMC article.
Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype. 

Fairfield H, Dudakovic A, Khatib CM, Farrell M, Costa S, Falank C, Hinge M, Murphy CS, DeMambro V, Pettitt JA, Lary CW, Driscoll HE, McDonald MM, Kassem M, Rosen C, Andersen TL, van Wijnen AJ, Jafari A, Reagan MR.

Cancer Res. 2021 Feb 1;81(3):634-647. doi: 10.1158/0008-5472.CAN-20-1088. Epub 2020 Nov 20.

PMID: 33218968 Free PMC article.
Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice. 

Moore ER, Mathews OA, Yao Y, Yang Y.

Bone. 2021 Feb;143:115738. doi: 10.1016/j.bone.2020.115738. Epub 2020 Nov 11.

PMID: 33188955 Free PMC article.
Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron. 

Marneros AG.

Cell Rep. 2021 Jan 12;34(2):108616. doi: 10.1016/j.celrep.2020.108616.

PMID: 33440155 Free PMC article.
Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells. 

Shivaraju M, Chitta UK, Grange RMH, Jain IH, Capen D, Liao L, Xu J, Ichinose F, Zapol WM, Mootha VK, Rajagopal J.

Science. 2021 Jan 1;371(6524):52-57. doi: 10.1126/science.aba0629.

PMID: 33384370 Free PMC article.
PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate. 

Nishimori S, Wein MN, Kronenberg HM.

Bone. 2021 Jan;142:115709. doi: 10.1016/j.bone.2020.115709. Epub 2020 Oct 24.

PMID: 33148508 Free PMC article.
Impact of Zika virus on the human type I interferon osteoimmune response. 

Drouin A, Wallbillich N, Theberge M, Liu S, Katz J, Bellovoda K, Se Yun Cheon S, Gootkind F, Bierman E, Zavras J, Berberich MJ, Kalocsay M, Guastaldi F, Salvadori N, Troulis M, Fusco DN.

Cytokine. 2021 Jan;137:155342. doi: 10.1016/j.cyto.2020.155342. Epub 2020 Oct 30.

PMID: 33130337
Sclerostin-Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters. 

Farrell M, Fairfield H, Costa S, D’Amico A, Falank C, Brooks DJ, Reagan MR.

J Bone Miner Res. 2021 Jan;36(1):158-169. doi: 10.1002/jbmr.4170. Epub 2020 Sep 23.

PMID: 32845528 Free PMC article.
Effects of Combination Denosumab and High-Dose Teriparatide Administration on Bone Microarchitecture and Estimated Strength: The DATA-HD HR-pQCT Study. 

Ramchand SK, David NL, Lee H, Bruce M, Bouxsein ML, Leder BZ, Tsai JN.

J Bone Miner Res. 2021 Jan;36(1):41-51. doi: 10.1002/jbmr.4161. Epub 2020 Sep 19.

PMID: 32790196 Clinical Trial.
Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification. 

Fairfield H, Costa S, DeMambro V, Schott C, Martins JDS, Ferron M, Vary C, Reagan MR.

JBMR Plus. 2020 Oct 14;4(11):e10413. doi: 10.1002/jbm4.10413. eCollection 2020 Nov.

PMID: 33210065 Free PMC article.
Effects of Sleeve Gastrectomy on Bone Marrow Adipose Tissue in Adolescents and Young Adults with Obesity. 

Bredella MA, Singhal V, Hazhir Karzar N, Animashaun A, Bose A, Stanford FC, Carmine B, Misra M.

J Clin Endocrinol Metab. 2020 Nov 1;105(11):e3961-70. doi: 10.1210/clinem/dgaa581.

PMID: 32827034 Free PMC article.
Circulating testican-2 is a podocyte-derived marker of kidney health. 

Ngo D, Wen D, Gao Y, Keyes MJ, Drury ER, Katz DH, Benson MD, Sinha S, Shen D, Farrell LA, Peterson BD, Friedman DJ, Elmariah S, Young BA, Smith JG, Yang Q, Vasan RS, Larson MG, Correa A, Humphreys BD, Wang TJ, Pollak MR, Wilson JG, Gerszten RE, Rhee EP.

Proc Natl Acad Sci U S A. 2020 Oct 6;117(40):25026-25035. doi: 10.1073/pnas.2009606117. Epub 2020 Sep 21.

PMID: 32958645 Free PMC article.
Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells. 

Ayturk UM, Scollan JP, Goz Ayturk D, Suh ES, Vesprey A, Jacobsen CM, Divieti Pajevic P, Warman ML.

J Bone Miner Res. 2020 Oct;35(10):1981-1991. doi: 10.1002/jbmr.4052. Epub 2020 Jul 20.

PMID: 32427356 Free PMC article.
Bone density, microarchitecture and strength estimates in white versus African American youth with obesity. 

Campoverde Reyes KJ, Stanford FC, Singhal V, Animashaun AO, Bose A, Gleeson EL, Bredella MA, Misra M.

Bone. 2020 Sep;138:115514. doi: 10.1016/j.bone.2020.115514. Epub 2020 Jul 1.

PMID: 32622072 Free PMC article.
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. 

Sato T, Verma S, Andrade CDC, Omeara M, Campbell N, Wang JS, Cetinbas M, Lang A, Ausk BJ, Brooks DJ, Sadreyev RI, Kronenberg HM, Lagares D, Uda Y, Pajevic PD, Bouxsein ML, Gross TS, Wein MN.

Nat Commun. 2020 Jul 1;11(1):3282. doi: 10.1038/s41467-020-17099-3.

PMID: 32612176 Free PMC article.
Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy. 

Yang YS, Xie J, Chaugule S, Wang D, Kim JM, Kim J, Tai PWL, Seo SK, Gravallese E, Gao G, Shim JH.

Mol Ther Methods Clin Dev. 2020 Apr 18;17:922-935. doi: 10.1016/j.omtm.2020.04.010. eCollection 2020 Jun 12.

PMID: 32405514 Free PMC article.
A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation. 

Kim JM, Yang YS, Park KH, Ge X, Xu R, Li N, Song M, Chun H, Bok S, Charles JF, Filhol-Cochet O, Boldyreff B, Dinter T, Yu PB, Kon N, Gu W, Takarada T, Greenblatt MB, Shim JH.

Nat Commun. 2020 May 8;11(1):2289. doi: 10.1038/s41467-020-16038-6.

PMID: 32385263 Free PMC article.
Bone outcomes following sleeve gastrectomy in adolescents and young adults with obesity versus non-surgical controls. 

Misra M, Singhal V, Carmine B, Bose A, Kelsey MM, Stanford FC, Bram J, Aidlen J, Inge T, Bouxsein ML, Bredella MA.

Bone. 2020 May;134:115290. doi: 10.1016/j.bone.2020.115290. Epub 2020 Feb 19.

PMID: 32084562 Free PMC article. Clinical Trial.
Improved GPCR ligands from nanobody tethering. 

Cheloha RW, Fischer FA, Woodham AW, Daley E, Suminski N, Gardella TJ, Ploegh HL.

Nat Commun. 2020 Apr 29;11(1):2087. doi: 10.1038/s41467-020-15884-8.

PMID: 32350260 Free PMC article.
Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk. 

Richard D, Liu Z, Cao J, Kiapour AM, Willen J, Yarlagadda S, Jagoda E, Kolachalama VB, Sieker JT, Chang GH, Muthuirulan P, Young M, Masson A, Konrad J, Hosseinzadeh S, Maridas DE, Rosen V, Krawetz R, Roach N, Capellini TD.

Cell. 2020 Apr 16;181(2):362-381.e28. doi: 10.1016/j.cell.2020.02.057. Epub 2020 Mar 26.

PMID: 32220312 Free PMC article.
At the Crossroads of the Adipocyte and Osteoclast Differentiation Programs: Future Therapeutic Perspectives. 

Muruganandan S, Ionescu AM, Sinal CJ.

Int J Mol Sci. 2020 Mar 26;21(7):2277. doi: 10.3390/ijms21072277.

PMID: 32224846 Free PMC article. Review.
Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. 

Simic P, Kim W, Zhou W, Pierce KA, Chang W, Sykes DB, Aziz NB, Elmariah S, Ngo D, Pajevic PD, Govea N, Kestenbaum BR, de Boer IH, Cheng Z, Christov M, Chun J, Leaf DE, Waikar SS, Tager AM, Gerszten RE, Thadhani RI, Clish CB, Jüppner H, Wein MN, Rhee EP.

J Clin Invest. 2020 Mar 2;130(3):1513-1526. doi: 10.1172/JCI131190.

PMID: 32065590 Free PMC article.
An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia. 

Noda H, Guo J, Khatri A, Dean T, Reyes M, Armanini M, Brooks DJ, Martins JS, Schipani E, Bouxsein ML, Demay MB, Potts JT Jr, Jüppner H, Gardella TJ.

J Bone Miner Res. 2020 Mar;35(3):540-549. doi: 10.1002/jbmr.3913. Epub 2019 Dec 4.

PMID: 31693237 Free PMC article.
Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial. 

Ackerman KE, Singhal V, Slattery M, Eddy KT, Bouxsein ML, Lee H, Klibanski A, Misra M.

J Bone Miner Res. 2020 Feb;35(2):248-260. doi: 10.1002/jbmr.3887. Epub 2019 Nov 7.

PMID: 31603998 Free PMC article. Clinical Trial.
Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model. 

Natoni A, Farrell ML, Harris S, Falank C, Kirkham-McCarthy L, Macauley MS, Reagan MR, O’Dwyer M.

Haematologica. 2020 Jan 31;105(2):457-467. doi: 10.3324/haematol.2018.212266. Print 2020.

PMID: 31101754 Free PMC article.
Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation. 

Matthias J, Cui Q, Shumate LT, Plagge A, He Q, Bastepe M.

Endocrinology. 2020 Jan 1;161(1):bqz025. doi: 10.1210/endocr/bqz025.

PMID: 31758181 Free PMC article.

2020

Gardner OF, Juneja SC, Whetstone H, et al. Effective repair of articular cartilage using human pluripotent stem cell-derived tissue. Eur Cell Mater. 2019;38:215-227. Published 2019 Nov 5. doi:10.22203/eCM.v038a15.
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Sato T, Verma S, Andrade CDC, et al. A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. Nat Commun. 2020;11(1):3282. Published 2020 Jul 1. doi:10.1038/s41467-020-17099-3.
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PMCID: PMC7329900
Balani DH, Kronenberg HM. Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo. Bone. 2019;118:16-19. doi:10.1016/j.bone.2018.05.024.
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Nishimori S, O'Meara MJ, Castro CD, et al. Salt-inducible kinases dictate parathyroid hormone 1 receptor action in bone development and remodeling. J Clin Invest. 2019;129(12):5187-5203. doi:10.1172/JCI130126.
PMID: 31430259
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Simic P, Kim W, Zhou W, et al. Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney. J Clin Invest. 2020;130(3):1513-1526. doi:10.1172/JCI131190.
PMID: 32065590
PMCID: PMC7269595
He Q, Shumate LT, Matthias J, et al. A G protein-coupled, IP3/protein kinase C pathway controlling the synthesis of phosphaturic hormone FGF23. JCI Insight. 2019;4(17):e125007. Published 2019 Sep 5. doi:10.1172/jci.insight.125007.
PMID: 31484825
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Sun N, Uda Y, Azab E, et al. Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. J Biol Chem. 2019;294(25):9722-9733. doi:10.1074/jbc.RA118.007312.
PMID: 31068415
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Grigelioniene G, Suzuki HI, Taylan F, et al. Gain-of-function mutation of microRNA-140 in human skeletal dysplasia. Nat Med. 2019;25(4):583-590. doi:10.1038/s41591-019-0353-2.
PMID: 30804514
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Daley EJ, Pajevic PD, Roy S, Trackman PC. Impaired Gastric Hormone Regulation of Osteoblasts and Lysyl Oxidase Drives Bone Disease in Diabetes Mellitus. JBMR Plus. 2019;3(10):e10212. Published 2019 Aug 7. doi:10.1002/jbm4.10212.
PMID: 31687648
PMCID: PMC6820454
Tsang K, Liu H, Yang Y, Charles JF, Ermann J. Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function. Bone. 2019;121:172-180. doi:10.1016/j.bone.2019.01.016.
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Urso K, Caetano-Lopes J, Lee PY, et al. A role for G protein-coupled receptor 137b in bone remodeling in mouse and zebrafish. Bone. 2019;127:104-113. doi:10.1016/j.bone.2019.06.002.
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Diegel CR, Hann S, Ayturk UM, et al. An osteocalcin-deficient mouse strain without endocrine abnormalities. PLoS Genet. 2020;16(5):e1008361. Published 2020 May 28. doi:10.1371/journal.pgen.1008361.
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Ayturk UM, Scollan JP, Goz Ayturk D, et al. Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells [published online ahead of print, 2020 May 19]. J Bone Miner Res. 2020;10.1002/jbmr.4052. doi:10.1002/jbmr.4052.
PMID: 32427356

2019

Gerli MFM, Guyette JP, Evangelista-Leite D, Ghoshhajra BB, Ott HC. Perfusion decellularization of a human limb: A novel platform for composite tissue engineering and reconstructive surgery. PLoS One
PMID: 29352303
PMCID: PMC5774802
Falank C, Fairfield H, Reagan MR. Reflections on Cancer in the Bone Marrow: Adverse Roles of Adipocytes. Curr Mol Biol Rep.
PMID: 29399440
PMCID: PMC5791905
Kiapour AM, Cao J, Young M, Capellini TD. The role of Gdf5 regulatory regions in development of hip morphology. PLoS One
PMID: 30388100
PMCID: PMC6214493
Liu S, Cheloha RW, Watanabe T, Gardella TJ, Gellman SH. Receptor selectivity from minimal backbone modification of a polypeptide agonist. Proc Natl Acad Sci U S A
PMID: 30442659
PMCID: PMC6298075
Tsang K, Liu H, Yang Y, Charles JF, Ermann J. Defective circadian control in mesenchymal cells reduces adult bone mass in mice by promoting osteoclast function. Bone
PMID: 30659979

2018

Dedic C, Hung TS, Shipley AM, Maeda A, Gardella T, Miller AL, Divieti Pajevic P, Kunkel JG, Rubinacci A. Calcium fluxes at the bone/plasma interface: Acute effects of parathyroid hormone (PTH) and targeted deletion of PTH/PTH-related peptide (PTHrP) receptor in the osteocytes Bone
PMID: PMID: 30053608
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Kobayashi T, Kozlova A. Lin28a overexpression reveals the role of Erk signaling in articular cartilage development. Development
PMID: 30042178
PMCID: PMC6110150
Herisson F, Frodermann V, Courties G, Rohde D, Sun Y, Vandoorne K, Wojtkiewicz GR, Masson GS, Vinegoni C, Kim J, Kim DE, Weissleder R, Swirski FK, Moskowitz MA, Nahrendorf M5. Direct vascular channels connect skull bone marrow and the brain surface enabling myeloid cell migration. Nat Neurosci
PMID: 30150661
PMCID: PMC6148759
Noguchi T, Hussein AI, Horowitz N, Carroll D, Gower AC, Demissie S, Gerstenfeld LC. Hypophosphatemia Regulates Molecular Mechanisms of Circadian Rhythm. Sci rep
PMID: 30213970
PMCID: PMC6137060
Wein MN, Foretz M, Fisher DE, Xavier RJ, Kronenberg HM. Salt-Inducible Kinases: Physiology, Regulation by cAMP, and Therapeutic Potential. Trends Endocrinol Metab
PMID: 30150136
PMCID: PMC6151151
Liu ES, Martins JS, Zhang W, Demay MB Molecular Analysis of Enthesopathy in a Mouse Model of Hypophosphatemic Rickets Development. 2018 Jul 12. pii: dev.163519. doi: 10.1242/dev.163519. [Epub ahead of print]
PMID: 30002128
Florian Kuehn, Fatemeh Adiliaghdam, Sulaiman R. Hamarneh, Robin Vasan, Enyu Liu, Yang Liu, Juan M. Ramirez, Raza S. Hoda, Alexander R. Munoz, Frank C. Ko, Michael Armanini, Daniel J. Brooks, Mary L. Bouxsein, Marie B. Demay, and Richard A. Hodin. Loss of intestinal alkaline phosphatase leads to distinct chronic changes in bone phenotype. Journal of Surgical Research Volume 232, December 2018, Pages 325-331.
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PMCID: DOI
Farrell ML, Reagan MR. Soluble and Cell-Cell-Mediated Drivers of Proteasome Inhibitor Resistance in Multiple Myeloma. Front Endocrinol (Lausanne). 2018 May 1;9:218. doi: 10.3389/fendo.2018.00218. eCollection 2018.
PMID: 29765356
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Karaca A, Malladi VR, Zhu Y, Tafaj O, Paltrinieri E, Wu JY, He Q, Bastepe M. Constitutive stimulatory G protein activity in limb mesenchyme impairs bone growth. Bone. 2018 May;110:230-237. doi: 10.1016/j.bone.2018.02.016. Epub 2018 Feb 20.
PMID: 29471062
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Balani DH, Kronenberg HM. Withdrawal of parathyroid hormone after prolonged administration leads to adipogenic differentiation of mesenchymal precursors in vivo. Bone. 2018 May 22. pii: S8756-3282(18)30214-X. doi: 10.1016/j.bone.2018.05.02.
PMID: 29800694
Pregizer SK, Kiapour AM, Young M, Chen H, Schoor M, Liu Z, Cao J, Rosen V, Capellini TD. Impact of broad regulatory regions on Gdf5 expression and function in knee development and susceptibility to osteoarthritis. Ann Rheum Dis. 2018 Mar;77(3):450. doi: 10.1136/annrheumdis-2017-212475. Epub 2018 Jan 8.
PMID: 29311146
Christov M, Clark AR, Corbin B, Hakroush S, Rhee EP, Saito H, Brooks D, Hesse E, Bouxsein M, Galjart N, Jung JY, Mundel P, Jüppner H, Weins A, Greka A. Inducible podocyte-specific deletion of CTCF drives progressive kidney disease and bone abnormalities. JCI Insight. 2018 Feb 22;3(4). pii: 95091. doi: 10.1172/jci.insight.95091. [Epub ahead of print].
PMID: 29467330
Singhal V, Tulsiani S, Campoverde KJ, Mitchell DM, Slattery M, Schorr M, Miller KK, Bredella MA, Misra M, Klibanski A. Impaired bone strength estimates at the distal tibia and its determinants in adolescents with anorexia nervosa. Bone. 2018;106:61-8.
PMID: 28694162
PMCID: PMC5694353

2017

James S. Lyons, Humberto C. Joca, Robert A. Law, Katrina M. Williams, Jaclyn P. Kerr, Guoli Shi,4 Ramzi J. Khairallah, Stuart S. Martin, Konstantinos Konstantopoulos, Christopher W. Ward, Joseph P. Stains Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes Science Signaling
PMID: Full Text
Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, Aldawood ZA, Lin CP, Intini G. Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration. Stem Cell Reports. 2017 Apr 11;8(4):933-946. doi: 10.1016/j.stemcr.2017.03.002. Epub 2017 Mar 30.
PMID: 28366454
PMCID: PMC5390237
Silva PPB, Amlashi FG, Yu EW, Pulaski-Liebert KJ, Gerweck AV, Fazeli PK, Lawson E, Nachtigall LB, Biller BMK, Miller KK, Klibanski A, Bouxsein M, Tritos NA. Bone microarchitecture and estimated bone strength in men with active acromegaly. Eur J Endocrinol. 2017 Nov;177(5):409-420. doi: 10.1530/EJE-17-0468. Epub 2017 Aug 5.
PMID: 28780520
Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017 Mar 7;25(3):661-672. doi: 10.1016/j.cmet.2017.01.001. Epub 2017 Feb 2. PubMed PMID: 28162969; PubMed Central
PMCID: PMC5342925
Kaludjerovic J, Komaba H, Sato T, Erben RG, Baron R, Olauson H, Larsson TE, Lanske B. Klotho expression in long bones regulates FGF23 production during renal failure. FASEB J. 2017 May;31(5):2050-2064. doi: 10.1096/fj.201601036R. Epub 2017 Feb 9. PubMed
PMID: 28183805
Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 Sep;92(3):599-611. doi: 10.1016/j.kint.2017.02.014. Epub 2017 Apr 8. PubMed
PMID: 28396120
Tokarz D, Martins JS, Petit ET, Lin CP, Demay MB, Liu ES. Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017
PMID: 29083055
Saini V, Zhao H, Petit ET, Gori F, Demay MB. Absence of vitamin D receptor (VDR)-mediated PPARgamma suppression causes alopecia in VDR-null mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017;31(3):1059-66.
PMID: 27932380
PMCID: PMC5295732
Roszko KL, Bi R, Gorvin CM, Brauner-Osborne H, Xiong XF, Inoue A, Thakker RV, Stromgaard K, Gardella T, Mannstadt M. Knockin mouse with mutant Galpha11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI insight. 2017;2(3):e91079. PMID: 28194446 PMCI: PMC5291736 associated with Shire/NPS Pharmaceuticals Inc. (USA), GlaxoSmithKline, Novartis Pharma AG, and Marshall-Smith Syndrome Foundation. KS is associated with Avilex Pharma (unrelated to this work).
PMID: 28194446
PMCID: PMC5291736
Rolvien T, Krause M, Jeschke A, Yorgan T, Puschel K, Schinke T, Busse B, Demay MB, Amling M. Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone. Bone. 2017;103:78-87.
PMID: 28666969
Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB. Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. The Journal of biological chemistry. 2017;292(8):3164-71.
PMID: 28073913
PMCID: PMC5336153
Lyons JS, Joca HC, Law RA, Williams KM, Kerr JP, Shi G, Khairallah RJ, Martin SS, Konstantopoulos K, Ward CW, Stains JP. Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes. Science signaling. 2017;10(506)
PMID: 29162742
Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Juppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PloS one. 2017;12(4):e0176232.
PMID: 28448530
PMCID: PMC5407772
Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(4):814-20.
PMID: 27925290
Knab VM, Corbin B, Andrukhova O, Hum JM, Ni P, Rabadi S, Maeda A, White KE, Erben RG, Juppner H, Christov M. Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels. Endocrinology. 2017;158(5):1130-9.
PMID: 28324013
PMCID: PMC5460828
Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nature communications. 2017;8(1):765.
PMID: 29018244
PMCID: PMC5635127
Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN. Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(5):892-901.
PMID: 27862326
PMCID: PMC5413385
He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M. Large G protein alpha-subunit XLalphas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(45):E9559-E68.
PMID: 29078380
PMCID: PMC5692581
Guo J, Khatri A, Maeda A, Potts JT, Jr., Juppner H, Gardella TJ. Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(1):86-98.
PMID: 27428040
PMCID: PMC5199614
Fulzele K, Lai F, Dedic C, Saini V, Uda Y, Shi C, Tuck P, Aronson JL, Liu X, Spatz JM, Wein MN, Divieti Pajevic P. Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(2):373-84.
PMID: 27653320
PMCID: PMC5525330
Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils. Science. 2017;358(6367)
PMID: 29191879
Capellini TD, Chen H, Cao J, Doxey AC, Kiapour AM, Schoor M, Kingsley DM. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017;49(8):1202-10.
PMID: 28671685
Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C. Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice. PloS one. 2017;12(7):e0180098.
PMID: 28704395
PMCID: PMC5509111
Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017;101:49-61.
PMID: 28412469
PMCID: PMC5500242
Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro AM, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial IM, Rosen CJ, Reagan MR. Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017;158(10):3369-85.
PMID: 28977604
PMCID: PMC5659683
Balani DH, Ono N, Kronenberg HM. Parathyroid hormone regulates fates of murine osteoblast precursors in vivo. J Clin Invest. 2017;127(9):3327-38.
PMID: 28758904
Roszko KL, Bi R, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors JCI Insight. 2017;2(3):e91079
PMCID: JCI Insight. 2017;2(3):e91079
Leder BZ Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy. Curr Osteoporos Rep. 2017;15(2):110-119
PMID: 28303448
PMCID: PMC5477638
Santoro N, Crawford SL, El Khoudary SR, Allshouse AA, Burnett-Bowie SA, Finkelstein J, Derby C, Matthews K, Kravitz HM, Harlow SD, Greendale GA, Gold EB, Kazlauskaite R, McConnell D, Neal-Perry G, Pavlovic J, Randolph J, Weiss G, Chen HY, Lasley B Menstrual Cycle Hormone Changes in Women Traversing the Menopause: Study Of Women’s Health Across the Nation. J Clin Endocrinol Metab. 2017;:ePub
PMID: 28368525
Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Sci Transl Med. 2017;9(387):ePub
PMID: 28446689
Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232
PMID: 28448530
PMCID: PMC5407772
Qin Y, Peng Y, Zhao W, Pan J, Ksiezak-Reding H, Cardozo C, Wu Y, Divieti Pajevic P, Bonewald LF, Bauman WA, Qin W Myostatin Inhibits Osteoblastic Differentiation by Suppressing Osteocyte-derived Exosomal microRNA-218: A Novel Mechanism in Muscle-Bone Communication. J Biol Chem. 2017;292(26):11021-11033
PMID: 28465350
PMCID: PMC5491785
Ikeda M, Kobayashi T, Suzuki T, Wakabayashi Y, Ohama Y, Maekawa S, Takahashi S, Homma Y, Tatsuno K, Sato T, Okugawa S, Moriya K, Yotsuyanagi H Propionimicrobium lymphophilum and Actinotignum schaalii bacteraemia: a case report. New Microbes New Infect. 2017;18:18-21
PMID: 28491325
PMCID: PMC5412094
Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts. J Bone Miner Res. 2017;32(5):892-901
PMCID: PMC5413385
Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem. 2017;292(8):3164-3171
PMCID: PMC5336153
Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232
PMCID: PMC5407772
Mitchell DM Growth in patients with type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2017;24(1):67-72
Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017;32(4):814-820
Grigelioniene G, Nevalainen PI, Reyes M, Thiele S, Tafaj O, Molinaro A, Takatani R, Ala-Houhala M, Nilsson D, Eisfeldt J, Lindstrand A, Kottler ML, Mäkitie O, Jüppner H A Large Inversion Involving GNAS Exon A/B and All Exons Encoding Gsα Is Associated With Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B). J Bone Miner Res. 2017;32(4):776-783
PMCID: PMC5395346
Yao Q, Yu C, Zhang X, Zhang K, Guo J, Song L Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism. Bone. 2017;97:175-183
Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017;25(3):661-672
PMCID: PMC5342925
Gardella TJ G-Protein-coupled receptors: Decoding mixed signals. Nat Chem Biol. 2017;13(3):247-248
Yu EW, Lee MP, Landon JE, Lindeman KG, Kim SC Fracture risk after bariatric surgery: Roux-en-Y gastric bypass versus adjustable gastric banding. J Bone Miner Res. 2017;:ePub
Leder BZ, Tsai JN, Jiang LA, Lee H Importance of prompt antiresorptive therapy in postmenopausal women discontinuing teriparatide or denosumab: The Denosumab and Teriparatide Follow-up study (DATA-Follow-up). Bone. 2017;98:54-58
Bulathsinhala L, Hughes JM, McKinnon CJ, Kardouni JR, Guerriere KI, Popp KL, Matheny RW, Bouxsein ML Risk of Stress Fracture Varies by Race/Ethnic Origin in a Cohort Study of 1.3 Million US Army Soldiers. J Bone Miner Res. 2017;:ePub
Mitchell DM, Jüppner H, Burnett-Bowie SM FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls. J Clin Endocrinol Metab. 2017;102(4):1151-1160
Knab VM, Corbin B, Andrukhova O, Hum JM, Ni P, Rabadi S, Maeda A, White KE, Erben RG, Jüppner H, Christov M Acute parathyroid hormone injection increases c-terminal, but not intact fibroblast growth factor 23 levels. Acute parathyroid hormone injection increases c-terminal, but not intact fibroblast growth factor 23 levels.
Bi R, Fan Y, Luo E, Yuan Q, Mannstadt M Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation. J Vis Exp. 2017;(121):ePub
Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Sci Transl Med. 2017;9(387):ePub
Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232
Saini V, Zhao H, Petit ET, Gori F, Demay MB Absence of vitamin D receptor (VDR)-mediated PPARγ suppression causes alopecia in VDR-null mice. FASEB J. 2017;31(3):1059-1066
PMCID: PMC5295732

2016

Amano K, Densmore M, Fan Y, Lanske B. Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones. Bone. 2016 Feb;83:256-66. doi: 10.1016/j.bone.2015.11.017. Epub 2015 Nov 24. PubMed
PMID: 26620087
Yu EW, Carmody JS, Brooks DJ, LaJoie S, Kaplan LM, Bouxsein ML. Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass. Bone. 2016;85:23-8.
PMID: 26806052
PMCID: PMC4792678
Xiong XF, Zhang H, Underwood CR, Harpsoe K, Gardella TJ, Woldike MF, Mannstadt M, Gloriam DE, Brauner-Osborne H, Stromgaard K. Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors. Nature chemistry. 2016;8(11):1035-41.
PMID: 27768111
PMCID: PMC5559716
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nature communications. 2016;7:13176. PMID: 27759007 PMCI: PMC5075806 receives grant support from Amgen, and has received consulting honorariums from Amgen and Novartis. M.B. receives grant support from Amgen and Merck, and serves on scientific advisory boards for Merck and Eli Lilly. T.S., R.X., H.M.K., and M.N.W. declare that patents have been filed for the therapeutic application of SIK inhibitors. The remaining authors declare no competing financial interests.
PMID: 27759007
PMCID: PMC5075806
Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016;157(10):4066-75.
PMID: 27526034
PMCID: PMC5045513
Shimizu M, Joyashiki E, Noda H, Watanabe T, Okazaki M, Nagayasu M, Adachi K, Tamura T, Potts JT, Jr., Gardella TJ, Kawabe Y. Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(7):1405-12.
PMID: 26865415
PMCID: PMC4935665
Papaioannou G, Mirzamohammadi F, Kobayashi T. Ras signaling regulates osteoprogenitor cell proliferation and bone formation. Cell Death Dis. 2016;7(10):e2405.
PMID: 27735946
PMCID: PMC5133981
O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016(111)
PMID: 27284788
PMCID: PMC4927747
Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nature communications. 2016;7:12047.
PMID: 27329220
PMCID: PMC4917962
Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B. A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. Journal of biomechanics. 2016;49(14):3549-54.
PMID: 27623705
PMCID: PMC5074880
Liu ES, Raimann A, Chae BT, Martins JS, Baccarini M, Demay MB. c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016;143(2):348-55.
PMID: 26657770
PMCID: PMC4725343
Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB. 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(5):929-39.
PMID: 26751835
PMCID: PMC4862933
Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(12):2204-14.
PMID: 27324177
Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ. Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling Endocrinology. 2016;157(1):141-9.
PMID: 26562265
PMCID: PMC4701881
Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC. Bioengineering Human Myocardium on Native Extracellular Matrix. Circulation research. 2016;118(1):56-72.
PMID: 26503464
PMCID: PMC4740234
Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(1):428-40.
PMID: 26428657
PMCID: PMC4684518
Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS. Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(6):1225-34.
PMID: 26763740
PMCID: PMC5002355
Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016;8(366):366ra163.
PMID: 27881824
Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ. Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS chemical biology. 2016;11(10):2752-62.
PMID: 27533344
PMCID: PMC5107307
Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015;30:428-40
PMID: 26428657
PMCID: PMC4684518
Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury Endocrinology. 2016;157(10):4066-4075
PMCID: PMC5045513
Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice J Bone Miner Res. 2016;32(4):814-820
Saini V, Zhao H, Petit ET, Gori F, Demay MB Absence of vitamin D receptor (VDR)-mediated PPARγ suppression causes alopecia in VDR-null mice FASEB J. 2016;31(3):1059-1066
PMCID: PMC5295732
Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKS control osteocyte responses to parathyroid hormone Nat Commun. 2016;7:13176
PMCID: PMC5075806
Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification Science Translational Medicine. 2016;8:366ra163
PMID: 27881824
Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development J Biomech. 2016;49(14):3549-3554
PMCID: PMC5074880
Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease J Bone Miner Res. 2016;31(6):1225-34
PMID: 26763740
Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass Bone. 2016;85:23-8
PMID: 26806052
PMCID: PMC4792678
Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression J Bone Miner Res. 2016;31 (5):929-39
PMID: 26751835
PMCID: PMC4862933
Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Raf Kinases are Essential for Phosphate Induction of Erk1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development J Biol Chem. 2017;292(8):3164-3171
PMCID: PMC5336153
Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment J Bone Miner Res. 2017;32(1):86-98
PMCID: PMC5199614
Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling Nat Commun. 2016;7:12047
PMCID: PMC4917962
Tsai JN, Burnett-Bowie SM, Lee H, Leder BZ Relationship between bone turnover and density with teriparatide, denosumab or both in women in the DATA study. Bone. 2016;95:20-25
Greenblatt MB, Tsai JN, Wein MN Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2016;63(2):464-474
Putman MS, Yu EW, Lin D, Darakananda K, Finkelstein JS, Bouxsein ML Differences in Trabecular Microstructure Between Black and White Women Assessed by Individual Trabecular Segmentation Analysis of HR-pQCT Images. J Bone Miner Res. 2016;:ePub
Solomon DH, Diem SJ, Ruppert K, Lian YJ, Liu CC, Wohlfart A, Greendale GA, Finkelstein JS Bone mineral density changes among women initiating proton pump inhibitors or H2 receptor antagonists: a SWAN cohort study J Bone Miner Res. 2015;30(2):232-9
PMID: 25156141
PMCID: PMC4404624
Tafaj O, Jüppner H Pseudohypoparathyroidism: one gene, several syndromes. J Endocrinol Invest. 2016;40(4):347-356
Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016;157(10):4066-4075
PMCID: PMC5045513
Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. J Biomech. 2016;49(14):3549-3554
PMCID: PMC5074880
Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS chemical biology. 2016;11(10):2752-62.
PMID: 27533344
PMCID: PMC5107307
Popp KL, Hughes JM, McKinnon CJ, Kardouni JR, Matheny RW, Bouxsein ML Ethinyl Estradiol-Containing Hormonal Contraceptive Prescriptions are Associated with Reduced Stress Fracture Risk in Female Soldiers: 3096 Board #161 June 3, 3: 30 PM – PM.5: 00 Med Sci Sports Exerc. 2016;48(5 Suppl 1):878
PMID: 27361665
Hughes JM, Popp KL, Yanovich R, Bouxsein ML, Matheny RW The role of adaptive bone formation in the etiology of stress fracture. Exp Biol Med (Maywood). 2016;242(9):897-906
PMID: 27496801
PMCID: PMC5407583
Shimizu M, Joyashiki E, Noda H, Watanabe T, Okazaki M, Nagayasu M, Adachi K, Tamura T, Potts JT, Gardella TJ, Kawabe Y Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys. J Bone Miner Res. 2016;31(7):1405-12
PMID: 26865415
PMCID: PMC4935665
Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol. 2016;72(Pt 5):603-15
PMID: 27139624
PMCID: PMC4854312
Nampoothiri S, Fernández-Rebollo E, Yesodharan D, Gardella TJ, Rush ET, Langman CB, Jüppner H Jansen Metaphyseal Chondrodysplasia due to heterozygous H223R-PTH1R mutations with or without overt hypercalcemia. J Clin Endocrinol Metab. 2016;:jc20162054
PMID: 27410178
PMCID: PMC5095231
Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT Management of Hypoparathyroidism: Summary Statement and Guidelines. J Clin Endocrinol Metab. 2016;101(6):2273-83
PMCID: 26943719
Clarke BL, Brown EM, Collins MT, Jüppner H, Lakatos P, Levine MA, Mannstadt MM, Bilezikian JP, Romanischen AF, Thakker RV Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016;101(6):2284-99
PMID: 26943720
PMCID: PMC5393595
Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016;27(8):2497-505
PMID: 26952010
PMCID: PMC4947435
Ono W, Sakagami N, Nishimori S, Ono N, Kronenberg HM Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation. Nat Commun. 2016;7:11277
PMID: 27068606
PMCID: PMC4832076
Leder BZ, Tsai JN, Burnett-Bowie SA, Bouxsein ML, Neer RM Letter to the editor in response to the commentary, "Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics. Bone. 2016;89:73-4
PMID: 27157641
Poradosu S, Bravenboer B, Takatani R, Jüppner H Pseudohypoparathyroidism type 1B caused by methylation changes at the GNAS complex locus. BMJ Case Rep. 2016;2016:ePub
PMID: 27170606
Shanbhogue VV, Finkelstein JS, Bouxsein ML, Yu EW Association Between Insulin Resistance and Bone Structure in Nondiabetic Postmenopausal Women. J Clin Endocrinol Metab. 2016;101(8):3114-22
PMID: 27243136
PMCID: PMC4971339
Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016;31(12):2204-2214
PMID: 27324177
Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047
PMID: 27329220
PMCID: PMC4917962
Ono N, Kronenberg HM Bone repair and stem cells. Curr Opin Genet Dev. 2016;40:103-107
PMID: 27399886
PMCID: PMC5135600
Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res. 2016;32(1):86-98
PMID: 27428040
PMCID: PMC5199614
Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(6):1225-34
PMID: 26763740
PMCID: PMC5002355
Yu EW, Carmody JS, Brooks DJ, LaJoie S, Kaplan LM, Bouxsein ML Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass. Bone. 2016;85:23-8
PMID: 26806052
PMCID: PMC4792678
Leder BZ, Tsai JN, Neer RM, Uihlein AV, Wallace PM, Burnett-Bowie SM Response to Therapy With Teriparatide, Denosumab, or Both in Postmenopausal Women in the DATA (Denosumab and Teriparatide Administration) Study Randomized Controlled Trial. J Clin Densitom. 2016;19(3):346-51
PMID: 26900146
Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int. 2016;89(4):939-48
PMID: 26924052
PMCID: PMC4801748
Ikeda S, Okamoto T, Okano S, Umemoto Y, Tagawa T, Morodomi Y, Kohno M, Shimamatsu S, Kitahara H, Suzuki Y, Fujishita T, Maehara Y PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer. J Thorac Oncol. 2016;11(1):62-71
PMID: 26762740
Kronenberg HM Bone and Mineral Metabolism: Where Are We, Where Are We Going, and How Will We Get There? J Clin Endocrinol Metab. 2016;101(3):795-8
PMID: 26908104
PMCID: PMC4803156
Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy. J Biol Chem. 2015;291(4):1631-42
PMID: 26598522
PMCID: PMC4722446
Kozhemyakina E, Zhang M, Ionescu A, Ayturk UM, Ono N, Kobayashi A, Kronenberg H, Warman ML, Lassar AB. Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rgenatol.. 2015;67:1261-73
PMID: 25603997
PMCID: 4414823
Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC Bioengineering Human Myocardium on Native Extracellular Matrix. Circulation research. 2016;118(1):56-72.
PMID: 26503464
PMCID: PMC4740234

2015

He Q, Zhu Y, Corbin BA, Plagge A, Bastepe M The G protein alpha subunit variant XLalphas promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo Science signaling. 2015;8(391):ra84
PMID: 26307011
PMCID: PMC4618482
Amano K, Densmore MJ, Lanske B. Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation. J Bone Miner Res. 2015 Dec;30(12):2262-72. doi: 10.1002/jbmr.2582. Epub 2015 Jul 29. PubMed
PMID: 26094741
Papaioannou G, Mirzamohammadi F, Lisse TS, Nishimori S, Wein MN, Kobayashi T. MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015;30(6):1044-52.
PMID: 25529628
PMCID: PMC5380142
Mayeur C, Kolodziej SA, Wang A, Xu X, Lee A, Yu PB, Shen J, Bloch KD, Bloch DB. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation. Haematologica. 2015;100(2):e68-71.
PMID: 25326432
PMCID: PMC4803128
Lee S, Mannstadt M, Guo J, Kim SM, Yi HS, Khatri A, Dean T, Okazaki M, Gardella TJ, Juppner H. A Homozygous [Cys25]PTH(1-84) Mutation That Impairs PTH/PTHrP Receptor Activation Defines a Novel Form of Hypoparathyroidism. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015;30(10):1803-13.
PMID: 25891861
PMCID: PMC4580526
Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW. Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage. Osteoarthritis and cartilage. 2015;23(7):1214-20.
PMID: 25707934
PMCID: PMC4470813
Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM. Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 2015;156(8):2774-80.
PMID: 26052897
PMCID: PMC4511135
He Q, Zhu Y, Corbin BA, Plagge A, Bastepe M. The G protein alpha subunit variant XLalphas promotes inositol 1,4,5-trisphosphate signaling and mediates the renal actions of parathyroid hormone in vivo. Science signaling. 2015;8(391):ra84.
PMID: 26307011
PMCID: PMC4618482
Gardella TJ, Vilardaga JP. International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors–family B G protein-coupled receptors. Pharmacological reviews. 2015;67(2):310-37.
PMID: 25713287
PMCID: PMC4394688
Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ. Actions of the small molecule ligands SW106 and AH-3960 on the type-1 parathyroid hormone receptor. Molecular endocrinology. 2015;29(2):307-21.
PMID: 25584411
PMCID: PMC4318877
Mayeur C, Kolodziej SA, Wang A, Xu X, Lee A, Yu PB, Shen J, Bloch KD, Bloch DB. Oral administration of a bone morphogenetic protein type I receptor inhibitor prevents the development of anemia of inflammation Haematologica. 2015;100(2):e68-71.
PMID: 25326432
PMCID: PMC4803128
Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC Bioengineering Human Myocardium on Native Extracellular Matrix Circ Res. 2015;118(1):56-72
PMID: 26503464
PMCID: PMC4740234
Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling Endocrinology. 2015;157(1):141-9
PMID: 26562265
PMCID: PMC4701881
Amano K, Densmore M, Fan Y, Lanske B Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones Bone. 2015;83:256-66
PMID: 26620087
Amano K, Densmore MJ, Lanske B Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation J Bone Miner Res. 2015;30(12):2262-72
PMID: 26094741
Papaioannou G, Mirzamohammadi F, Lisse TS, Nishimori S, Wein MN, Kobayashi T MicroRNA-140 Provides Robustness to the Regulation of Hypertrophic Chondrocyte Differentiation by the PTHrP-HDAC4 Pathway Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015;30(6):1044-52
PMID: 25529628
PMCID: PMC5380142
Kobayashi T, Papaioannou G, Mirzamohammadi F, Kozhemyakina E, Zhang M, Blelloch R, Chong MW Early postnatal ablation of the microRNA-processing enzyme, Drosha, causes chondrocyte death and impairs the structural integrity of the articular cartilage Osteoarthritis and Cartilage. 2015;23(7):1214-20
PMID: 25707934
PMCID: PMC4470813
Liu ES, Raimann A, Chae BT, Martins JS, Baccarini M, Demay MB c-Raf promotes angiogenesis during normal growth plate maturation Development. 2015;143(2):348-55
PMID: 26657770
PMCID: PMC4725343
Ren X, Moser PT, Gilpin SE, Okamoto T, Wu T, Tapias LF, Mercier FE, Xiong L, Ghawi R, Scadden DT, Mathisen DJ, Ott HC Engineering pulmonary vasculature in decellularized rat and human lungs Nat Biotechnol. 2015;33(10):1097-102
PMID: 26368048
Solomon DH, Ruppert K, Zhao Z, Lian YJ, Kuo IH, Greendale GA, Finkelstein JS Bone mineral density changes among women initiating blood pressure lowering drugs: a SWAN cohort study Osteoporos Int. 2015;27(3):1181-9
PMID: 26449354
PMCID: PMC4813302
Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling. Endocrinology. 2015;157(1):141-9
PMID: 26562265
PMCID: PMC4701881
Yu EW, Wewalka M, Ding SA, Simonson DC, Foster K, Holst JJ, Vernon A, Goldfine AB, Halperin F Effects of Gastric Bypass and Gastric Banding on Bone Remodeling in Obese Patients With Type 2 Diabetes J Clin Endocrinol Metab. 2015;101(2):714-22
PMID: 26600045
PMCID: PMC4880129
Zhu Y, He Q, Aydin C, Rubera I, Tauc M, Chen M, Weinstein LS, Marshansky V, Jüppner H, Bastepe M Ablation of the Stimulatory G Protein α-Subunit in Renal Proximal Tubules Leads to Parathyroid Hormone-Resistance With Increased Renal Cyp24a1 mRNA Abundance and Reduced Serum 1,25-Dihydroxyvitamin D. Endocrinology. 2015;157(2):497-507
PMID: 26671181
PMCID: PMC4733111
Hirai T, Kobayashi T, Nishimori S, Karaplis AC, Goltzman D, Kronenberg HM Bone Is a Major Target of PTH/PTHrP Receptor Signaling in Regulation of Fetal Blood Calcium Homeostasis. Endocrinology. 2015;156(8):2774-80
PMID: 26052897
PMCID: PMC4511135
Ono N, Kronenberg HM Mesenchymal progenitor cells for the osteogenic lineage. Curr Mol Biol Rep. 2015;1(3):95-100
PMID: 26526380
PMCID: PMC4624419
Vaidya A, Curhan GC, Paik JM, Kronenberg H, Taylor EN Hypertension, Antihypertensive Medications, and Risk of Incident Primary Hyperparathyroidism. J Clin Endocrinol Metab. 2015;100(6):2396-404
PMID: 25885946
PMCID: PMC4454810
Pereira RC, Jüppner H, Gales B, Salusky IB, Wesseling-Perry K Osteocytic protein expression response to doxercalciferol therapy in pediatric dialysis patients. PLoS One. 2015;10(3):e0120856
PMID: 25774916
PMCID: PMC4361624
Daniels GH, Hegedüs L, Marso SP, Nauck MA, Zinman B, Bergenstal RM, Mann JF, Derving Karsbøl J, Moses AC, Buse JB, Tuttle RM, LEADER 2: baseline calcitonin in 9340 people with type 2 diabetes enrolled in the Liraglutide Effect and Action in Diabetes: Evaluation of cardiovascular outcome Results (LEADER) trial: preliminary observations. Diabetes Obes Metab. 2015;17(5):477-86
PMID: 25656058
PMCID: PMC4405040
Cheng S, Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A, Magnusson M, Souza AL, Deik AA, Pierce KA, Bullock K, O'Donnell CJ, Melander O, Clish CB, Vasan RS, Gerszten RE, Wang TJ Erratum: Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. 2015;6:7317
PMID: 25993905
Cheng S, Larson MG, McCabe EL, Murabito JM, Rhee EP, Ho JE, Jacques PF, Ghorbani A, Magnusson M, Souza AL, Deik AA, Pierce KA, Bullock K, O'Donnell CJ, Melander O, Clish CB, Vasan RS, Gerszten RE, Wang TJ Distinct metabolomic signatures are associated with longevity in humans. Nat Commun. 2015;6:6791
PMID: 25864806
PMCID: PMC4396657
Cauley JA, Greendale GA, Ruppert K, Lian Y, Randolph JF, Lo JC, Burnett-Bowie SA, Finkelstein JS Serum 25 hydroxyvitamin D, bone mineral density and fracture risk across the menopause. J Clin Endocrinol Metab. 2015;100(5):2046-54
PMID: 25719933
PMCID: PMC4422899
Carhill AA, Litofsky DR, Ross DS, Jonklaas J, Cooper DS, Brierley JD, Ladenson PW, Ain KB, Fein HG, Haugen BR, Magner J, Skarulis MC, Steward DL, Xing M, Maxon HR, Sherman SI Long-Term Outcomes Following Therapy in Differentiated Thyroid Carcinoma: NTCTCS Registry Analysis 1987-2012. J Clin Endocrinol Metab. 2015;100(9):3270-9
PMID: 26171797
PMCID: PMC5393522
Bréhin AC, Colson C, Maupetit-Méhouas S, Grybek V, Richard N, Linglart A, Kottler ML, Jüppner H Loss of methylation at GNAS exon A/B is associated with increased intrauterine growth J Clin Endocrinol Metab. 2015;100(4):E623-31
PMID: 25603460
PMCID: PMC4399294
Bi R, Fan Y, Lauter K, Hu J, Watanabe T, Cradock J, Yuan Q, Gardella T, Mannstadt M Diphtheria Toxin- and GFP-Based Mouse Models of Acquired Hypoparathyroidism and Treatment with a Long-Acting Parathyroid Hormone Analog J Bone Miner Res. 2015;31(5):975-84
PMID: 26678919
PMCID: PMC4862881
Baker JF, Putman MS, Herlyn K, Tillotson AP, Finkelstein JS, Merkel PA Body composition, lung function, and prevalent and progressive bone deficits among adults with cystic fibrosis. Joint Bone Spine. 2015;83(2):207-11
PMID: 26677995
Turan S, Bastepe M GNAS Spectrum of Disorders. Curr Osteoporos Rep. 2015;13(3):146-58
PMID: 25851935
PMCID: PMC4417430
Putman MS, Bouxsein ML, Finkelstein JS Response letter to the editor J Clin Endocrinol Metab. 2015;100(1):L9-L10
PMID: 25559548
Takatani R, Molinaro A, Grigelioniene G, Tafaj O, Watanabe T, Reyes M, Sharma A, Singhal V, Raymond FL, Linglart A, Jüppner H Analysis of Multiple Families with Single Individuals Affected by Pseudohypoparathyroidism Type Ib (PHP1B) Reveals Only One Novel Maternally Inherited GNAS Deletion. J Bone Miner Res. 2015;31(4):796-805
PMID: 26479409
PMCID: PMC4826817
Mitchell DM, Leder BZ, Cagliero E, Mendoza N, Henao MP, Hayden DL, Finkelstein JS, Burnett-Bowie SA Insulin secretion and sensitivity in healthy adults with low vitamin D are not affected by high-dose ergocalciferol administration: a randomized controlled trial. Am J Clin Nutr. 2015;102(2):385-92
PMID: 26156733
PMCID: PMC4515870
Shanbhogue VV, Mitchell DM, Rosen CJ, Bouxsein ML Type 2 diabetes and the skeleton: new insights into sweet bones. Lancet Diabetes Endocrinol. 2015;4(2):159-73
PMID: 26365605
Tsai JN, Uihlein AV, Burnett-Bowie SA, Neer RM, Zhu Y, Derrico N, Lee H, Bouxsein ML, Leder BZ Comparative effects of teriparatide, denosumab, and combination therapy on peripheral compartmental bone density, microarchitecture, and estimated strength: the DATA-HRpQCT Study. J Bone Miner Res. 2015;30(1):39-45
PMID: 25043459
PMCID: PMC4396184
Gardella TJ, Vilardaga JP International Union of Basic and Clinical Pharmacology. XCIII. The parathyroid hormone receptors–family B G protein-coupled receptors. Pharmacological reviews. 2015;67(2):310-37
PMID: 25713287
PMCID: PMC4394688
Panaroni C, Fulzele K, Saini V, Chubb R, Pajevic PD, Wu JY PTH Signaling in Osteoprogenitors Is Essential for B-Lymphocyte Differentiation and Mobilization J Bone Miner Res. 2015;30 (12):2273-2286
PMID: 26191777
PMCID: PMC5056164
Cheloha RW, Gellman SH, Vilardaga JP, Gardella TJ PTH receptor-1 signalling-mechanistic insights and therapeutic prospects. Nat Rev Endocrinol. 2015;11 (12):712-724
PMID: 26303600
PMCID: PMC4651712
Bastepe M, Xin W Huntington Disease: Molecular Diagnostics Approach. Curr Protoc Hum Genet. 2015;87:9.26.1-9.26.23
PMID: 26439718
Tsai JN, Zhu Y, Foley K, Lee H, Burnett-Bowie SA, Neer RM, Leder BZ Comparative Resistance to Teriparatide-Induced Bone Resorption With Denosumab or Alendronate. J Clin Endocrinol Metab. 2015;100(7):2718-23
PMID: 25933031
PMCID: PMC5393530
Spatz JM, Wein MN, Gooi JH, Qu Y, Garr JL, Liu S, Barry KJ, Uda Y, Lai F, Dedic C, Balcells- Camps M, Kronenberg HM, Babij P, Pajevic PD The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro. J Biol Chem. 2015;290(27):16744-58
PMID: 25953900
PMCID: PMC4505423
Mitchell DM, Tuck P, Ackerman KE, Cano Sokoloff N, Woolley R, Slattery M, Lee H, Bouxsein ML, Misra M Altered trabecular bone morphology in adolescent and young adult athletes with menstrual dysfunction. Bone. 2015;81:24-30
PMID: 26123592
PMCID: PMC4745258
Leder BZ, Tsai JN, Uihlein AV, Wallace PM, Lee H, Neer RM, Burnett-Bowie SM Denosumab and teriparatide transitions in postmenopausal osteoporosis (the DATA-Switch study): extension of a randomised controlled trial. Lancet. 2015;386(9999):1147-55
PMID: 26144908
PMCID: PMC4620731
Molinaro A, Tiosano D, Takatani R, Chrysis D, Russell W, Koscielniak N, Kottler ML, Agretti P, De Marco G, Ahtiainen P, Christov M, Mäkitie O, Tonacchera M, Jüppner H TSH Elevations as the First Laboratory Evidence for Pseudohypoparathyroidism Type Ib (PHP-Ib). J Bone Miner Res. 2015;30(5):906-12
PMID: 25403028
PMCID: PMC4401615
Yu EW, Bouxsein ML, Putman MS, Monis EL, Roy AE, Pratt JS, Butsch WS, Finkelstein JS Two-year changes in bone density after Roux-en-Y gastric bypass surgery. J Clin Endocrinol Metab. 2015;100(4):1452-9
PMID: 25646793
PMCID: PMC4399296
Lee S, Mannstadt M, Guo J, Kim SM, Yi HS, Khatri A, Dean T, Okazaki M, Gardella TJ, Jüppner H A Homozygous [Cys25]PTH(1-84) Mutation that Impairs PTH/PTHrP Receptor Activation Defines a Novel form of Hypoparathyroidism. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2015;30(10):1803-13
PMID: 25891861
PMCID: PMC4580526
Yu VW, Saez B, Cook C, Lotinun S, Pardo-Saganta A, Wang YH, Lymperi S, Ferraro F, Raaijmakers MH, Wu JY, Zhou L, Rajagopal J, Kronenberg HM, Baron R, Scadden DT Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med. 2015;212(5):759-74
PMID: 25918341
PMCID: PMC4419348
Monis EL, Mannstadt M Hypoparathyroidism – disease update and emerging treatments. Ann Endocrinol (Paris). 2015;76(2):84-8
PMID: 25882889
Takatani R, Minagawa M, Molinaro A, Reyes M, Kinoshita K, Takatani T, Kazukawa I, Nagatsuma M, Kashimada K, Sato K, Matsushita K, Nomura F, Shimojo N, Jüppner H. Similar frequency of paternal uniparental disomy involving chromosome 20q (patUPD20q) in Japanese and Caucasian patients affected by sporadic pseudohypoparathyroidism type Ib (sporPHP1B). Bone. 2015;79:15-20
PMID: 25997889
PMCID: PMC4501871
Fazeli PK, Faje AT, Cross EJ, Lee H, Rosen CJ, Bouxsein ML, Klibanski A. Serum FGF-21 levels are associated with worsened radial trabecular bone microarchitecture and decreased radial bone strength in women with anorexia nervosa. Bone. 2015;77:6-11.
PMID: 25868802
PMCID: PMC4447546
Putman MS, Baker JF, Uluer A, Herlyn K, Lapey A, Sicilian L, Tillotson AP, Gordon CM, Merkel PA, Finkelstein JS Trends in bone mineral density in young adults with cystic fibrosis over a 15year period, J Cyst Fibros. 2015;14(4):526-32
PMID: 25698451
PMCID: PMC4485936
Leder BZ, O'Dea LS, Zanchetta JR, Kumar P, Banks K, McKay K, Lyttle CR, Hattersley G Effects of abaloparatide, a human parathyroid hormone-related Peptide analog, on bone mineral density in postmenopausal women with osteoporosis. J Clin Endocrinol Metab. 2015;100(2):697-706
PMID: 25393645
Carter PH, Dean T, Bhayana B, Khatri A, Rajur R, Gardella TJ Actions of the Small Molecule Ligands SW106 and AH-3960 on the Type-1 Parathyroid Hormone Receptor. Molecular endocrinology. 2015;29(2):307-21
PMID: 25584411
PMCID: PMC4318877
Yu EW, Putman MS, Derrico N, Abrishamanian-Garcia G, Finkelstein JS, Bouxsein ML Defects in cortical microarchitecture among African-American women with type 2 diabetes. Osteoporos Int. 2015;26:673-79
PMID: 25398431
PMCID: PMC4400116
Turan S, Thiele S, Tafaj O, Brix B, Atay Z, Abali S, Haliloglu B, Bereket A, Bastepe M Evidence of hormone resistance in a pseudo-pseudohypoparathyroidism patient with a novel paternal mutation in GNAS. Bone. 2015;71:53-57
PMID: 25464124
PMCID: PMC4273232
Wein MN, Spatz J, Nishimori S, Doench J, Root D, Babij P, Nagano K, Baron R, Brooks D, Bouxsein M, Pajevic PD, Kronenberg HM HDAC5 controls MEF2C-driven sclerostin expression in osteocytes. J Bone Miner Res. 2015;30 (3):400-411
PMID: 25271055
PMCID: PMC4342334

2014

Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH. Backbone modification of a polypeptide drug alters duration of action in vivo. Nature biotechnology. 2014;32(7):653-5.
PMID: 24929976
PMCID: PMC4205942
Yu EW, Putman MS, Derrico N, Abrishamanian-Garcia G, Finkelstein JS, Bouxsein ML Defects in cortical microarchitecture among African-American women with type 2 diabetes. Osteoporos Int. 2014;26(2):673-9
PMID: 25398431
PMCID: PMC4400116
Portale AA, Wolf M, Jüeppner H, Messinger S, Kumar J, Wesseling-Perry K, Schwartz GJ, Furth SL, Warady BA, Salusky IB Disordered FGF23 and mineral metabolism in children with CKD Clin J Am Soc Nephrol. 2014;9(2):344-53
PMID: 24311704
PMCID: PMC3913243
Ono N, Ono W, Nagasawa T, Kronenberg HM A subset of chondrogenic cells provides early mesenchymal progenitors in growing bones. Nat Cell Biol. 2014;16(12):1157-67
PMID: 25419849
PMCID: PMC4250334
Lai LP, Lotinun S, Bouxsein ML, Baron R, McMahon AP Stk11 (Lkb1) deletion in the osteoblast lineage leads to high bone turnover, increased trabecular bone density and cortical porosity. Bone. 2014;69C:98-108
PMID: 25240456
PMCID: PMC4373701
Lisse TS, Saini V, Zhao H, Luderer HF, Gori F, Demay MB. The Vitamin D Receptor Is Required for Activation of cWnt and Hedgehog Signaling in Keratinocytes. Mol Endocrinol.. 2014;28:1698-706
PMID: 25180455
PMCID: PMC4179637
Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, LeShan Wilson T, Rankin EB, Giaccia AJ, Schipani E Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014;393(1):124-36
PMID: 24972088
PMCID: PMC4335807
Jahollari A, Sarac A, Tafaj O, Ozal E Surgical management of a giant right coronary artery aneurysm. Heart Surg Forum. 2014;17(4):236-7
PMID: 25179967
Nistala H, Mäkitie O, Jüeppner H Caffey disease: new perspectives on old questions. Bone. 2014;60:246-51
PMID: 24389367
PMCID: PMC3987944
Dasgupta D, Wee MJ, Reyes M, Li Y, Simm PJ, Sharma A, Schlingmann KP, Janner M, Biggin A, Lazier J, Gessner M, Chrysis D, Tuchman S, Baluarte HJ, Levine MA, Tiosano D, Insogna K, Hanley DA, Carpenter TO, Ichikawa S, Hoppe B, Konrad M, Sävendahl L, Munns C Mutations in SLC34A3/NPT2c Are Associated with Kidney Stones and Nephrocalcinosis. J Am Soc Nephrol. 2014;25:2366-75
PMID: 24700880
PMCID: PMC4178443
Wesseling-Perry K, Wang H, Elashoff R, Gales B, Jüppner H, Salusky IB Lack of FGF23 response to acute changes in serum calcium and PTH in humans. J Clin Endocrinol Metab. 2014;99:E1951-6
PMID: 25062462
PMCID: PMC5393489
Christov M Fibroblast growth factor 23 in acute kidney injury. Curr Opin Nephrol Hypertens. 2014;23(4):340-5
PMID: 24848938
PMCID: PMC4183160
Yu EW, Bouxsein ML, Roy AE, Baldwin C, Cange A, Neer RM, Kaplan LM, Finkelstein JS Bone loss after bariatric surgery: discordant results between DXA and QCT bone density. J Bone Miner Res. 2014;29(3):542-50
PMID: 23929784
PMCID: PMC3918250
Singhal V, Lawson EA, Ackerman KE, Fazeli PK, Clarke H, Lee H, Eddy K, Marengi DA, Derrico NP, Bouxsein ML, Misra M Irisin levels are lower in young amenorrheic athletes compared with eumenorrheic athletes and non-athletes and are associated with bone density and strength estimates. PLoS One. 2014;9(6):e100218
PMID: 24926783
PMCID: PMC4057451
Putman MS, Milliren CE, Derrico N, Uluer A, Sicilian L, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS Compromised Bone Microarchitecture and Estimated Bone Strength in Young Adults with Cystic Fibrosis. J Clin Endocrinol Metab. 2014;99:3399-407
PMID: 24926955
PMCID: PMC4154107
Turan S, Fernandez-Rebollo E, Aydin C, Zoto T, Reyes M, Bounoutas G, Chen M, Weinstein LS, Erben RG, Marshansky V, Bastepe M Postnatal establishment of allelic Gαs silencing as a plausible explanation for delayed onset of parathyroid hormone resistance owing to heterozygous Gαs disruption. J Bone Miner Res. 2014;29(3):749-60
PMID: 23956044
PMCID: PMC3926912
Liu ES, Zalutskaya A, Chae BT, Zhu ED, Gori F, Demay MB Phosphate Interacts with PTHrP to Regulate Endochondral Bone Formation. Endocrinology. 2014;155:3750-6
PMID: 25057796
PMCID: PMC4164920
Manolagas SC, Kronenberg HM Reproducibility of Results in Pre-Clinical Studies: A Perspective from the Bone Field. J Bone Miner Res. 2014;29:2131-40
PMID: 24916175
PMCID: PMC4356005
Yu EW, Kumbhani R, Siwila-Sackman E, DeLelys M, Preffer FI, Leder BZ, Wu JY Teriparatide (PTH 1-34) treatment increases peripheral hematopoietic stem cells in postmenopausal women. J Bone Miner Res. 2014;29(6):1380-6
PMID: 24420643
PMCID: PMC4564394
Fazeli PK, Wang IS, Miller KK, Herzog DB, Misra M, Lee H, Finkelstein JS, Bouxsein ML, Klibanski A Teriparatide increases bone formation and bone mineral density in adult women with anorexia nervosa. J Clin Endocrinol Metab. 2014;99(4):1322-9
PMID: 24456286
PMCID: PMC3973785
Leder BZ, Tsai JN, Uihlein AV, Burnett-Bowie SA, Zhu Y, Foley K, Lee H, Neer RM Two years of Denosumab and teriparatide administration in postmenopausal women with osteoporosis (The DATA Extension Study): a randomized controlled trial. J Clin Endocrinol Metab. 2014;99(5):1694-700
PMID: 24517156
PMCID: PMC4010689
Uihlein AV, Finkelstein JS, Lee H, Leder BZ FSH suppression does not affect bone turnover in eugonadal men. J Clin Endocrinol Metab. 2014;99(7):2510-5
PMID: 24646101
PMCID: PMC4079307
Kaufmann M, Gallagher JC, Peacock M, Schlingmann KP, Konrad M, DeLuca HF, Sigueiro R, Lopez B, Mourino A, Maestro M, St-Arnaud R, Finkelstein JS, Cooper DP, Jones G Clinical utility of simultaneous quantitation of 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D by LC-MS/MS involving derivatization with DMEQ-TAD. J Clin Endocrinol Metab. 2014;99(7):2567-74
PMID: 24670084
PMCID: PMC4079315
Sinha P, Aarnisalo P, Chubb R, Ono N, Fulzele K, Selig M, Saeed H, Chen M, Weinstein LS, Divieti Pajevic P, Kronenberg HM, Wu JY Loss of Gs α Early in the Osteoblast Lineage Favors Adipogenic Differentiation of Mesenchymal Progenitors and Committed Osteoblast Precursors. J Bone Miner Res. 2014;29(11):2414-26
PMID: 24806274
PMCID: PMC4220542
Cheloha RW, Maeda A, Dean T, Gardella TJ, Gellman SH Backbone modification of a polypeptide drug alters duration of action in vivo. Nature biotechnology. 2014;32(7):653-5
PMID: 24929976
PMCID: PMC4205942
Lin Z, Feng R, Li J, Meng Y, Yuan L, Fu Z, Guo J, Bringhurst FR, Yang D Nuclear translocation of CBP/p300-interacting protein CITED1 induced by parathyroid hormone requires serine phosphorylation at position 79 in its 63-84 domain Cell Signal. 2014;26(11):2436-2445
PMID: 25049079
Gidon A, Al-Bataineh MM, Jean-Alphonse FG, Stevenson HP, Watanabe T, Louet C, Khatri A, Calero G, Pastor-Soler NM, Gardella TJ, Vilardaga JP Endosomal GPCR signaling turned off by negative feedback actions of PKA and v-ATPase. Nat Chem Biol. 2014;10(9):707-9
PMID: 25064832
PMCID: PMC4138287
Mirzamohammadi F, Papaioannou G, Kobayashi T microRNAs in Cartilage Development, Homeostasis, and Disease. Curr Osteoporos Rep. 2014;12(4):410-9
PMID: 25091054
PMCID: PMC4234170
Papaioannou G, Mirzamohammadi F, Kobayashi T. MicroRNAs involved in bone formation. Cell Mol Life Sci. 2014;71:4747-61
PMID: 25108446
PMCID: PMC4234685
Vilardaga JP, Jean-Alphonse FG, Gardella TJ Endosomal generation of cAMP in GPCR signaling. Nat Chem Biol.. 2014;10:700-6
PMID: 25271346
PMCID: PMC4417940
Kobayashi T, Kronenberg HM Overview of skeletal development. Methods Mol Biol. 2014;1130:3-12
PMID: 24482161
Pellicelli M, Miller JA, Arabian A, Gauthier C, Akhouayri O, Wu JY, Kronenberg HM, St-Arnaud R The PTH-Gαs-protein kinase A cascade controls αNAC localization to regulate bone mass. Mol Cell Biol. 2014;34(9):1622-33
PMID: 24550008
PMCID: PMC3993600
Chagin AS, Vuppalapati KK, Kobayashi T, Guo J, Hirai T, Chen M, Offermanns S, Weinstein LS, Kronenberg HM G-protein stimulatory subunit alpha and Gq/11α G-proteins are both required to maintain quiescent stem-like chondrocytes. Nat Commun. 2014;5:3673
PMID: 24781502
PMCID: PMC4154354
Mizoguchi T, Pinho S, Ahmed J, Kunisaki Y, Hanoun M, Mendelson A, Ono N, Kronenberg HM, Frenette PS Osterix marks distinct waves of primitive and definitive stromal progenitors during bone marrow development. Dev Cell. 2014;29(3):340-9
PMID: 24823377
PMCID: PMC4051418
Zhu ED, Louis L, Brooks DJ, Bouxsein ML, Demay MB Effect of bisphosphonates on the rapidly growing male murine skeleton. Endocrinology. 2014;155(4):1188-96
PMID: 24422540
PMCID: PMC3959604
Ono N, Ono W, Mizoguchi T, Nagasawa T, Frenette PS, Kronenberg HM Vasculature-associated cells expressing nestin in developing bones encompass early cells in the osteoblast and endothelial lineage. Dev Cell. 2014;29(3):330-9
PMID: 24823376
PMCID: PMC4083679