Publications supported by the Center for Musculoskeletal Research
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2025 PUBLICATIONS |
| Glycerol-3-phosphate contributes to the increase in FGF23 production in chronic kidney disease
Simic P, Xie H, Zhang Q, et al. Glycerol-3-phosphate contributes to the increase in FGF23 production in chronic kidney disease.Am J Physiol Renal Physiol. 2025;328(2):F165-F172. doi:10.1152/ajprenal.00311.2024 |
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2024 PUBLICATIONS |
| Adolescent Girls With Type 1 Diabetes Develop Changes in Bone Prior to Evidence of Clinical Neuropathy
Shen I, Usala RL, Mohseni M, Bouxsein ML, Mitchell DM, Scheller EL. Adolescent girls with type 1 diabetes develop changes in bone prior to evidence of clinical neuropathy.J Clin Endocrinol Metab. Published online July 26, 2024. doi:10.1210/clinem/dgae511 |
| SOST/Sclerostin impairs the osteogenesis and angiogesis in glucocorticoid-associated osteonecrosis of femoral head
Huang J, Ma T, Wang C, Wang Z, Wang X, Hua B, Jiang C, Yan Z. SOST/Sclerostin impairs the osteogenesis and angiogesis in glucocorticoid-associated osteonecrosis of femoral head. Mol Med. 2024 Sep 28;30(1):167. https://doi: 10.1186/s10020-024-00933-5 |
| Nitric oxide contributes to rapid sclerostin protein loss following mechanical load Buck HV, Torre OM, Leser JM, Gould NR, Ward CW, Stains JP. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. Biochem Biophys Res Commun. 2024 Oct 1;727:150315. doi: 10.1016/j.bbrc.2024.150315. Epub 2024 Jun 27. PMID: 38950493 |
| Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone
Emerzian SR, Chow J, Behzad R, et al. Long-duration type 1 diabetes is associated with deficient cortical bone mechanical behavior and altered matrix composition in human femoral bone.J Bone Miner Res. 2024;40(1):87-99. doi:10.1093/jbmr/zjae184 |
| Evaluation of Osteogenic Phenotype in Postmenopausal Women Receiving Anabolic and Antiresorptive Osteoporosis Therapies Kobelski MM, Ramchand SK, Tsai JN, Leder BZ, Demay MB. Evaluation of Osteogenic Phenotype in Postmenopausal Women Receiving Anabolic and Antiresorptive Osteoporosis Therapies.Endocrinology. 2024 Oct 30;165(12):bqae142. doi: 10.1210/endocr/bqae142. PMCID: PMC11523613. |
| Load-to-strength ratio as an estimate of wrist facture after gastric bypass vs gastric banding Jung GH, Zahedi B, Bouxsein ML, Yu EW. Load-to-strength ratio as an estimate of wrist facture after gastric bypass vs gastric banding.JBMR Plus. 2024;9(3):ziae175. Published 2024 Dec 30. doi:10.1093/jbmrpl/ziae175 |
| Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults Mitchell DM, Singhal V, Nimmala S, et al. Risk of wrist fracture, estimated by the load-to-strength ratio, declines following sleeve gastrectomy in adolescents and young adults.Osteoporos Int. 2024;35(2):285-291. doi:10.1007/s00198-023-06941-1 |
| The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH
Sorsby M, Almardini S, Alayyat A, et al. The role of GDF5 in regulating enthesopathy development in the Hyp mouse model of XLH.J Bone Miner Res. 2024;39(8):1162-1173. doi:10.1093/jbmr/zjae086 |
| NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling
Jagga S, Hughes A, Manoochehri Arash N, et al. NFATc1 Is Required for Vitamin D- and Phosphate-Mediated Regulation of Osteocyte Lacuno-Canalicular Remodeling.Endocrinology. 2024;165(8):bqae087. doi:10.1210/endocr/bqae087 |
| Bone loss with aging is independent of gut microbiome in mice
You X, Yan J, Herzog J, et al. Bone loss with aging is independent of gut microbiome in mice.Bone Res. 2024;12(1):65. Published 2024 Nov 11. doi:10.1038/s41413-024-00366-0 |
| Culturing Osteochondral Explants Under Rotary Shaking or After Removing Bone Marrow Elements Increases Explant Cellular Viability
Leite CBG, Ormsby RT, Mekhail J, et al. Culturing Osteochondral Explants Under Rotary Shaking or After Removing Bone Marrow Elements Increases Explant Cellular Viability.Am J Sports Med. 2024;52(9):2384-2390. doi:10.1177/03635465241254401 |
| Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner
Karagianni A, Karkempetzaki AI, Brooks D, et al. Deletion of mouse lysyl oxidase in megakaryocytes affects bone properties in a sex-dependent manner.Blood. 2024;143(25):2666-2670. doi:10.1182/blood.2024024620 |
| Amyloid-β neuropathology induces bone loss in male mice by suppressing bone formation and enhancing bone resorption
Jung Y, Ay B, Cyr SM, et al. Amyloid-β neuropathology induces bone loss in male mice by suppressing bone formation and enhancing bone resorption.Bone Rep. 2024;21:101771. Published 2024 Apr 28. doi:10.1016/j.bonr.2024.101771 |
| Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases
Tokavanich N, Chan B, Strauss K, et al. Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases. Preprint.bioRxiv. 2024;2024.09.04.611228. Published 2024 Sep 6. doi:10.1101/2024.09.04.611228 |
| Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk
Coveney CR, Maridas D, Chen H, Muthuirulan P, Liu Z, Jagoda E, Yarlagadda S, Movahhedi M, Proffen B, Rosen V, Kiapour AM, Capellini TD. Complex regulatory interactions at GDF5 shape joint morphology and osteoarthritis disease risk. bioRxiv [Preprint]. 2024 Nov 1:2024.11.01.621374. doi: 10.1101/2024.11.01.621374. PMID: 39554166; PMCID: PMC11565913. |
| A latent Axin2+/Scx+ progenitor pool is the central organizer of tendon healing
Grinstein M, Tsai SL, Montoro D, Freedman BR, Dingwall HL, Villaseñor S, Zou K, Sade-Feldman M, Tanaka MJ, Mooney DJ, Capellini TD, Rajagopal J, Galloway JL. A latent Axin2+/Scx+ progenitor pool is the central organizer of tendon healing. NPJ Regen Med. 2024 Oct 17;9(1):30. doi: 10.1038/s41536-024-00370-2. PMID: 39420021; PMCID: PMC11487078 |
| Nitric oxide contributes to rapid sclerostin protein loss following mechanical load
Buck HV, Torre OM, Leser JM, Gould NR, Ward CW, Stains JP. Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. Biochem Biophys Res Commun. 2024 Oct 1;727:150315. doi: 10.1016/j.bbrc.2024.150315. Epub 2024 Jun 27. PMID: 38950493. |
| Gα11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia
Ay B, Cyr SM, Klovdahl K, Zhou W, Tognoni CM, Iwasaki Y, Rhee EP, Dedeoglu A, Simic P, Bastepe M. Gα11 deficiency increases fibroblast growth factor 23 levels in a mouse model of familial hypocalciuric hypercalcemia. JCI Insight. 2024 Mar 26;9(9):e178993. doi: 10.1172/jci.insight.178993. PMID: 38530370; PMCID: PMC11141917. |
| Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis
Cong Q, Yang Y. Hedgehog Signaling Controls Chondrogenesis and Ectopic Bone Formation via the Yap-Ihh Axis. Biomolecules. 2024 Mar 14;14(3):347. doi: 10.3390/biom14030347. PMID: 38540766; PMCID: PMC10968511. |
| Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A
Papaioannou G, Sato T, Houghton C, Kotsalidis PE, Strauss KE, Dean T, Nelson AJ, Stokes M, Gardella TJ, Wein MN. Regulation of intracellular cAMP levels in osteocytes by mechano-sensitive focal adhesion kinase via PDE8A. bioRxiv [Preprint]. 2024 Jun 28:2024.06.28.601153. doi: 10.1101/2024.06.28.601153. PMID: 38979143; PMCID: PMC11230356. |
| Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants
Liu S, Daley EJ, Tran LM, Yu Z, Reyes M, Dean T, Khatri A, Levine PM, Balana AT, Pratt MR, Jüppner H, Gellman SH, Gardella TJ. Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants. J Am Chem Soc. 2024 Mar 13;146(10):6522-6529. doi: 10.1021/jacs.3c09694. Epub 2024 Feb 28. PMID: 38417010; PMCID: PMC11162201. |
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EARLIER PUBLICATIONS |
| Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling
Yadav PS, Kobelski MM, Martins JS, Tao T, Liu ES, Demay MB. Impaired Growth Plate Maturation in XLH Is due to Both Excess FGF23 and Decreased 1,25-Dihydroxyvitamin D Signaling. Endocrinology. 2023;165(1):bqad186. DOI: 10.1210/endocr/bqad186 |
| Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes
Yadav PS, Papaioannou G, Kobelski MM, Demay MB. Phosphate-induced activation of VEGFR2 leads to caspase-9-mediated apoptosis of hypertrophic chondrocytes. iScience. 2023;26(9):107548. Published 2023 Aug 7. doi:10.1016/j.isci.2023.107548 |
| Oxidative metabolism is impaired by phosphate deficiency during fracture healing and is mechanistically related to BMP induced chondrocyte differentiation.
Hussein AI, Carroll D, Bui M, Wolff A, Matheny H, Hogue B, Lybrand K, Cooke M, Bragdon B, Morgan E, Demissie S, Gerstenfeld L. Bone Rep. 2023 Jan 23;18:101657. doi: 10.1016/j.bonr.2023.101657. PMID: 37425193; PMCID: PMC10323218. |
| Altered Signaling and Desensitization Responses in PTH1R Mutants Associated with Eiken Syndrome
Portales-Castillo I, Dean T, Cheloha RW, Creemer BA, Vilardaga JP, Savransky S, Khatri A, Jüppner H, Gardella TJ. . Commun Biol. 2023 Jun 2;6(1):599. doi: 10.1038/s42003-023-04966-0. PMID: 37268817; PMCID: PMC10238420. |
| Limited roles of Piezo mechanosensing channels in articular cartilage development and osteoarthritis progression.
Young C, Kobayashi T. Osteoarthritis Cartilage. 2023 Jun;31(6):775-779. doi: 10.1016/j.joca.2023.01.576. Epub 2023 Feb 17. PMID: 36805475 |
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Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study. Mitchell DM, Singhal V, Animashaun A, Bose A, Carmine B, Stanford FC, Inge TH, Kelsey MM, Lee H, Bouxsein ML, Yu EW, Bredella MA, Misra M. J Clin Endocrinol Metab. 2023 Mar 10;108(4):847-857. doi: 10.1210/clinem/dgac634. PMID: 36314507; PMCID: PMC10211497. |
| Protectin DX as a therapeutic strategy against frailty in mice.
Perazza LR, Gower AC, Brown-Borg HM, Pajevic PD, Thompson LV. Geroscience. 2023 Apr 14. doi: 10.1007/s11357-023-00789-3. Online ahead of print. PMID: 37059838 |
| Differences in bone accrual over one year in young girls with obesity compared to Normal weight controls.
Singhal V, Kaur S, Haidar LA, Lee H, Bredella MA, Misra M. Bone. 2023 Apr 6;172:116757. doi: 10.1016/j.bone.2023.116757. Online ahead of print. PMID: 37030498 |
| Skeletal Effects of Sleeve Gastrectomy in Adolescents and Young Adults: A 2-Year Longitudinal Study.
Mitchell DM, Singhal V, Animashaun A, Bose A, Carmine B, Stanford FC, Inge TH, Kelsey MM, Lee H, Bouxsein ML, Yu EW, Bredella MA, Misra M. J Clin Endocrinol Metab. 2023 Mar 10;108(4):847-857. doi: 10.1210/clinem/dgac634. PMID: 36314507 |
| Endogenous Tenocyte Activation Underlies the Regenerative Capacity of Adult Zebrafish Tendon.
Tsai SL, Villasenor S, Shah R, Galloway JL. bioRxiv. 2023 Feb 4:2023.02.04.527141. doi: 10.1101/2023.02.04.527141. Preprint. PMID: 36778338 Free PMC article. |
| The PYY/Y2R-deficient male mouse is not protected from bone loss due to Roux-en-Y gastric bypass.
Zahedi B, Daley EJ, Brooks DJ, Bruce M, Townsend RL, Berthoud HR, Bouxsein ML, Yu EW. Bone. 2023 Feb;167:116608. doi: 10.1016/j.bone.2022.116608. Epub 2022 Nov 8. PMID: 36368466 |
| WNT-modulating gene silencers as a gene therapy for osteoporosis, bone fracture, and critical-sized bone defects.
Oh WT, Yang YS, Xie J, Ma H, Kim JM, Park KH, Oh DS, Park-Min KH, Greenblatt MB, Gao G, Shim JH. Mol Ther. 2023 Feb 1;31(2):435-453. doi: 10.1016/j.ymthe.2022.09.018. Epub 2022 Oct 3. PMID: 36184851 |
| Testican-2 Is Associated with Reduced Risk of Incident ESKD.
Wen D, Zhou L, Zheng Z, Surapaneni A, Ballantyne CM, Hoogeveen RC, Shlipak MG, Waikar SS, Vasan RS, Kimmel PL, Dubin RF, Deo R, Feldman HI, Ganz P, Coresh J, Grams ME, Rhee EP; CKD Biomarkers Consortium. J Am Soc Nephrol. 2023 Jan 1;34(1):122-131. doi: 10.1681/ASN.2022020216. Epub 2022 Oct 26. PMID: 36288905 |
| Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice.
Sato T, Andrade CDC, Yoon SH, Zhao Y, Greenlee WJ, Weber PC, Viswanathan U, Kulp J, Brooks DJ, Demay MB, Bouxsein ML, Mitlak B, Lanske B, Wein MN. Proc Natl Acad Sci U S A. 2022 Dec 13;119(50):e2214396119. doi: 10.1073/pnas.2214396119. Epub 2022 Dec 6. PMID: 36472957 Free PMC article. |
| Denosumab versus intravenous bisphosphonate use for hypercalcemia in multiple myeloma.
Lei MM, Tavares E, Buzgo E, Lou U, Raje N, Yee AJ. Leuk Lymphoma. 2022 Dec;63(13):3249-3252. doi: 10.1080/10428194.2022.2115840. Epub 2022 Aug 29. PMID: 36036363 No abstract available. |
| Impaired mitochondrial oxidative metabolism in skeletal progenitor cells leads to musculoskeletal disintegration.
Lin C, Yang Q, Guo D, Xie J, Yang YS, Chaugule S, DeSouza N, Oh WT, Li R, Chen Z, John AA, Qiu Q, Zhu LJ, Greenblatt MB, Ghosh S, Li S, Gao G, Haynes C, Emerson CP, Shim JH. Nat Commun. 2022 Nov 11;13(1):6869. doi: 10.1038/s41467-022-34694-8. PMID: 36369293 Free PMC article. |
| Denosumab increases spine bone density in women with anorexia nervosa: a randomized clinical trial.
Haines MS, Kimball A, Meenaghan E, Santoso K, Colling C, Singhal V, Ebrahimi S, Gleysteen S, Schneider M, Ciotti L, Belfer P, Eddy KT, Misra M, Miller KK. Eur J Endocrinol. 2022 Oct 13;187(5):697-708. doi: 10.1530/EJE-22-0248. Print 2022 Nov 1. PMID: 36134902 Clinical Trial. |
| Sustained Morphine Delivery Suppresses Bone Formation and Alters Metabolic and Circulating miRNA Profiles in Male C57BL/6J Mice.
Carvalho AL, Brooks DJ, Barlow D, Langlais AL, Morrill B, Houseknecht KL, Bouxsein ML, Lian JB, King T, Farina NH, Motyl KJ. J Bone Miner Res. 2022 Nov;37(11):2226-2243. doi: 10.1002/jbmr.4690. Epub 2022 Sep 26. PMID: 36054037 |
| Load-to-strength ratio at the radius is higher in adolescent and young adult females with obesity compared to normal-weight controls.
Singhal V, Huynh C, Nimmala S, Mitchell DM, Pedreira CC, Bader A, Flanders K, Zheng J, Bouxsein ML, Misra M, Bredella MA. Bone. 2022 Nov;164:116515. doi: 10.1016/j.bone.2022.116515. Epub 2022 Aug 7. PMID: 35948256 |
| Dickkopf-1 directs periosteal bone formation in two murine models of inflammatory arthritis.
Shaw AT, Yan J, Kuhstoss SA, Charles JF, Gravallese EM. Scand J Rheumatol. 2022 Nov;51(6):495-499. doi: 10.1080/03009742.2022.2040136. Epub 2022 Mar 11. PMID: 35272576 |
| Metabolite profiling of CKD progression in the chronic renal insufficiency cohort study.
Wen D, Zheng Z, Surapaneni A, Yu B, Zhou L, Zhou W, Xie D, Shou H, Avila-Pacheco J, Kalim S, He J, Hsu CY, Parsa A, Rao P, Sondheimer J, Townsend R, Waikar SS, Rebholz CM, Denburg MR, Kimmel PL, Vasan RS, Clish CB, Coresh J, Feldman HI, Grams ME, Rhee EP; CKD Biomarkers Consortium and CRIC Study Investigators. JCI Insight. 2022 Oct 24;7(20):e161696. doi: 10.1172/jci.insight.161696. PMID: 36048534 Free PMC article. |
| Suppression of heterotopic ossification in fibrodysplasia ossificans progressiva using AAV gene delivery.
Yang YS, Kim JM, Xie J, Chaugule S, Lin C, Ma H, Hsiao E, Hong J, Chun H, Shore EM, Kaplan FS, Gao G, Shim JH. Nat Commun. 2022 Oct 19;13(1):6175. doi: 10.1038/s41467-022-33956-9. PMID: 36258013 Free PMC article. |
| PTH, FGF-23, Klotho and Vitamin D as regulators of calcium and phosphorus: Genetics, epigenetics and beyond.
Portales-Castillo I, Simic P. Front Endocrinol (Lausanne). 2022 Sep 29;13:992666. doi: 10.3389/fendo.2022.992666. eCollection 2022. PMID: 36246903 Free PMC article. Review. |
| Partial prevention of glucocorticoid-induced osteocyte deterioration in young male mice with osteocrin gene therapy.
Mazur CM, Castro Andrade CD, Tokavanich N, Sato T, Bruce M, Brooks DJ, Bouxsein ML, Wang JS, Wein MN. iScience. 2022 Aug 27;25(9):105019. doi: 10.1016/j.isci.2022.105019. eCollection 2022 Sep 16. PMID: 36105586 Free PMC article. |
| AAV-mediated delivery of osteoblast/osteoclast-regulating miRNAs for osteoporosis therapy.
John AA, Xie J, Yang YS, Kim JM, Lin C, Ma H, Gao G, Shim JH. Mol Ther Nucleic Acids. 2022 Jul 11;29:296-311. doi: 10.1016/j.omtn.2022.07.008. eCollection 2022 Sep 13. PMID: 35950212 Free PMC article. |
| Changes in Sex Steroids and Enteric Peptides After Sleeve Gastrectomy in Youth in Relation to Changes in Bone Parameters.
Nimmala S, Kaur S, Singhal V, Mitchell DM, Stanford FC, Bouxsein ML, Lauze M, Huynh C, Pedreira CC, Lee H, Bredella MA, Misra M. J Clin Endocrinol Metab. 2022 Aug 18;107(9):e3747-e3758. doi: 10.1210/clinem/dgac361. PMID: 35689793 |
| Biphasic regulation of osteoblast development via the ERK MAPK-mTOR pathway.
Kim JM, Yang YS, Hong J, Chaugule S, Chun H, van der Meulen MCH, Xu R, Greenblatt MB, Shim JH. Elife. 2022 Aug 17;11:e78069. doi: 10.7554/eLife.78069. PMID: 35975983 Free PMC article. |
| A naturally occurring membrane-anchored Gαs variant, XLαs, activates phospholipase Cβ4.
Phan HTN, Loomis J, Abraham S, He Q, Bastepe M, Smrcka AV. J Biol Chem. 2022 Aug;298(8):102134. doi: 10.1016/j.jbc.2022.102134. Epub 2022 Jun 13. PMID: 35709985 Free PMC article. |
| CGRP and Shh Mediate the Dental Pulp Cell Response to Neuron Stimulation.
Moore ER, Michot B, Erdogan O, Ba A, Gibbs JL, Yang Y. J Dent Res. 2022 Aug;101(9):1119-1126. doi: 10.1177/00220345221086858. Epub 2022 Apr 11. PMID: 35403480 |
| Regulation of sclerostin by the SIRT1 stabilization pathway in osteocytes.
Kim JM, Yang YS, Xie J, Lee O, Kim J, Hong J, Boldyreff B, Filhol O, Chun H, Greenblatt MB, Gao G, Shim JH. Cell Death Differ. 2022 Aug;29(8):1625-1638. doi: 10.1038/s41418-022-00952-x. Epub 2022 Feb 15. PMID: 35169297 |
| Actions of Parathyroid Hormone Ligand Analogues in Humanized PTH1R Knockin Mice.
Daley EJ, Yoon SH, Reyes M, Bruce M, Brooks DJ, Bouxsein M, Potts JT, Kronenberg HM, Wein MN, Lanske B, Jüppner H, Gardella TJ. Endocrinology. 2022 Jul 1;163(7):bqac054. doi: 10.1210/endocr/bqac054. PMID: 35460406 Free PMC article. |
| Overexpression of transcription factor FoxA2 in the developing skeleton causes an enlargement of the cartilage hypertrophic zone, but it does not trigger ectopic differentiation in immature chondrocytes.
Bell N, Bhagat S, Muruganandan S, Kim R, Ho K, Pierce R, Kozhemyakina E, Lassar AB, Gamer L, Rosen V, Ionescu AM. Bone. 2022 Jul;160:116418. doi: 10.1016/j.bone.2022.116418. Epub 2022 Apr 6. PMID: 35398294 |
| Physiologic Transdermal Estradiol Replacement Mimics Effects of Endogenous Estrogen on Bone Outcomes in Hypoestrogenic Women with Anorexia Nervosa.
Singhal V, Nimmala S, Slattery M, Eddy KT, Miller KK, Klibanski A, Misra M. Nutrients. 2022 Jun 21;14(13):2557. doi: 10.3390/nu14132557. PMID: 35807738 Free PMC article. |
| A FoxA2+ long-term stem cell population is necessary for growth plate cartilage regeneration after injury.
Muruganandan S, Pierce R, Teguh DA, Perez RF, Bell N, Nguyen B, Hohl K, Snyder BD, Grinstaff MW, Alberico H, Woods D, Kong Y, Sima C, Bhagat S, Ho K, Rosen V, Gamer L, Ionescu AM. Nat Commun. 2022 May 6;13(1):2515. doi: 10.1038/s41467-022-30247-1. PMID: 35523895 Free PMC article. |
| Propranolol Promotes Bone Formation and Limits Resorption Through Novel Mechanisms During Anabolic Parathyroid Hormone Treatment in Female C57BL/6J Mice.
Treyball A, Bergeron AC, Brooks DJ, Langlais AL, Hashmi H, Nagano K, Barlow D, Neilson RJ, Roy TA, Nevola KT, Houseknecht KL, Baron R, Bouxsein ML, Guntur AR, Motyl KJ. J Bone Miner Res. 2022 May;37(5):954-971. doi: 10.1002/jbmr.4523. Epub 2022 Mar 10. PMID: 35122666 Free PMC article. |
| Impact of GH administration on skeletal endpoints in adults with overweight/obesity.
Dichtel LE, Haines MS, Gerweck AV, Bollinger B, Kimball A, Schoenfeld D, Bredella MA, Miller KK. Eur J Endocrinol. 2022 Apr 21;186(6):619-629. doi: 10.1530/EJE-21-1061. PMID: 35315344 Free PMC article. Clinical Trial. |
| Loss of Vlk in Prx1+ Cells Delays the Initial Steps of Endochondral Bone Formation and Fracture Repair in the Limb.
Maridas DE, Gamer L, Moore ER, Doedens AM, Yu Y, Ionescu A, Revollo L, Whitman M, Rosen V. J Bone Miner Res. 2022 Apr;37(4):764-775. doi: 10.1002/jbmr.4514. Epub 2022 Feb 16. PMID: 35080046 |
| Hyperphosphatemia increases inflammation to exacerbate anemia and skeletal muscle wasting independently of FGF23-FGFR4 signaling.
Czaya B, Heitman K, Campos I, Yanucil C, Kentrup D, Westbrook D, Gutierrez O, Babitt JL, Jung G, Salusky IB, Hanudel M, Faul C. Elife. 2022 Mar 18;11:e74782. doi: 10.7554/eLife.74782. PMID: 35302487 Free PMC article. |
| Multiple myeloma cells induce lipolysis in adipocytes and uptake fatty acids through fatty acid transporter proteins.
Panaroni C, Fulzele K, Mori T, Siu KT, Onyewadume C, Maebius A, Raje N. Blood. 2022 Feb 10;139(6):876-888. doi: 10.1182/blood.2021013832. PMID: 34662370 Free PMC article. |
| Mouse LGR6 regulates osteogenesis in vitro and in vivo through differential ligand use.
Khedgikar V, Charles JF, Lehoczky JA. Bone. 2022 Feb;155:116267. doi: 10.1016/j.bone.2021.116267. Epub 2021 Nov 29. PMID: 34856421 |
| The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation.
Revollo L, Merrill-Skoloff G, De Ceunynck K, Dilks JR, Guo S, Bordoli MR, Peters CG, Noetzli L, Ionescu A, Rosen V, Italiano JE, Whitman M, Flaumenhaft R. Blood. 2022 Jan 6;139(1):104-117. doi: 10.1182/blood.2020010342. PMID: 34329392 Free PMC article. |
| Bone marrow endothelial dysfunction promotes myeloid cell expansion in cardiovascular disease.
Rohde D, Vandoorne K, Lee IH, Grune J, Zhang S, McAlpine CS, Schloss MJ, Nayar R, Courties G, Frodermann V, Wojtkiewicz G, Honold L, Chen Q, Schmidt S, Iwamoto Y, Sun Y, Cremer S, Hoyer FF, Iborra-Egea O, Muñoz-Guijosa C, Ji F, Zhou B, Adams RH, Wythe JD, Hidalgo J, Watanabe H, Jung Y, van der Laan AM, Piek JJ, Kfoury Y, Désogère PA, Vinegoni C, Dutta P, Sadreyev RI, Caravan P, Bayes-Genis A, Libby P, Scadden DT, Lin CP, Naxerova K, Swirski FK, Nahrendorf M. Nat Cardiovasc Res. 2022 Jan;1(1):28-44. doi: 10.1038/s44161-021-00002-8. Epub 2021 Dec 23. PMID: 35747128 Free PMC article. |
| Age-Related Changes in Bone Density, Microarchitecture, and Strength in Postmenopausal Black and White Women: The SWAN Longitudinal HR-pQCT Study.
Johannesdottir F, Putman MS, Burnett-Bowie SM, Finkelstein JS, Yu EW, Bouxsein ML. J Bone Miner Res. 2022 Jan;37(1):41-51. doi: 10.1002/jbmr.4460. Epub 2021 Nov 9. PMID: 34647644 Free PMC article. |
| The effect of short-term high-caloric feeding and fasting on bone microarchitecture.
Bredella MA, Fazeli PK, Bourassa J, Rosen CJ, Bouxsein ML, Klibanski A, Miller KK. Bone. 2022 Jan;154:116214. doi: 10.1016/j.bone.2021.116214. Epub 2021 Sep 25. PMID: 34571202 Free PMC article. |
| Fibroblast Growth Factor 23 Regulation and Acute Kidney Injury.
Zhou W, Simic P, Rhee EP. Nephron. 2022;146(3):239-242. doi: 10.1159/000517734. Epub 2021 Jul 20. PMID: 34284404 Free PMC article. Review. |
| Parathyroid hormone signaling in mature osteoblasts/osteocytes protects mice from age-related bone loss.
Uda Y, Saini V, Petty CA, Alshehri M, Shi C, Spatz JM, Santos R, Newell CM, Huang TY, Kochen A, Kim JW, Constantinou CK, Saito H, Held KD, Hesse E, Pajevic PD. Aging (Albany NY). 2021 Dec 30;13(24):25607-25642. doi: 10.18632/aging.203808. Epub 2021 Dec 30. PMID: 34968192 Free PMC article. |
| Dnmt3a-mutated clonal hematopoiesis promotes osteoporosis.
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| Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation.
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| tiRNA signaling via stress-regulated vesicle transfer in the hematopoietic niche.
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| Regulation of FGF23: Beyond Bone.
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| Single-Cell Profiling Reveals Metabolic Reprogramming as a Resistance Mechanism in BRAF-Mutated Multiple Myeloma.
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| Genes with specificity for expression in the round cell layer of the growth plate are enriched in genomewide association study (GWAS) of human height.
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| Human prostate cancer bone metastases have an actionable immunosuppressive microenvironment.
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| Control of osteocyte dendrite formation by Sp7 and its target gene osteocrin.
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| Dynamic transcriptional reprogramming leads to immunotherapeutic vulnerabilities in myeloma.
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| Sequential Therapy With Recombinant Human IGF-1 Followed by Risedronate Increases Spine Bone Mineral Density in Women With Anorexia Nervosa: A Randomized, Placebo-Controlled Trial.
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| Bone marrow adipose tissue composition following high-caloric feeding and fasting.
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| Spatial bias in cAMP generation determines biological responses to PTH type 1 receptor activation.
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| Lipocalin 2 stimulates bone fibroblast growth factor 23 production in chronic kidney disease.
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| Phosphate restriction impairs mTORC1 signaling leading to increased bone marrow adipose tissue and decreased bone in growing mice.
Ko FC, Kobelski MM, Zhang W, Grenga GM, Martins JS, Demay MB. J Bone Miner Res. 2021 Aug;36(8):1510-1520. doi: 10.1002/jbmr.4312. Epub 2021 Jun 4. PMID: 33900666 |
| Joint disease-specificity at the regulatory base-pair level.
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| Glycerol-3-phosphate and fibroblast growth factor 23 regulation.
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| Stat3 loss in mesenchymal progenitors causes Job syndrome-like skeletal defects by reducing Wnt/β-catenin signaling.
Yadav PS, Feng S, Cong Q, Kim H, Liu Y, Yang Y. Proc Natl Acad Sci U S A. 2021 Jun 29;118(26):e2020100118. doi: 10.1073/pnas.2020100118. PMID: 34172578 Free PMC article. |
| A self-amplifying loop of YAP and SHH drives formation and expansion of heterotopic ossification.
Cong Q, Liu Y, Zhou T, Zhou Y, Xu R, Cheng C, Chung HS, Yan M, Zhou H, Liao Z, Gao B, Bocobo GA, Covington TA, Song HJ, Su P, Yu PB, Yang Y. Sci Transl Med. 2021 Jun 23;13(599):eabb2233. doi: 10.1126/scitranslmed.abb2233. PMID: 34162750 Free PMC article. |
| Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
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| The dynamics of human bone marrow adipose tissue in response to feeding and fasting.
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| Effect of Transdermal Estradiol and Insulin-like Growth Factor-1 on Bone Endpoints of Young Women With Anorexia Nervosa.
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| Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH.
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| The impact of genetic background and sex on the phenotype of IL-23 induced murine spondyloarthritis.
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| Comparable Initial Engagement of Intracellular Signaling Pathways by Parathyroid Hormone Receptor Ligands Teriparatide, Abaloparatide, and Long-Acting PTH.
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| Changes in marrow adipose tissue in relation to changes in bone parameters following estradiol replacement in adolescent and young adult females with functional hypothalamic amenorrhea.
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| Sclerostin Antibody Administration Increases the Numbers of Sox9creER+ Skeletal Precursors and Their Progeny.
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| Multiple Myeloma Cells Alter Adipogenesis, Increase Senescence-Related and Inflammatory Gene Transcript Expression, and Alter Metabolism in Preadipocytes.
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| Ligand-Dependent Effects of Methionine-8 Oxidation in Parathyroid Hormone Peptide Analogues.
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| Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype.
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| Prx1-expressing cells contributing to fracture repair require primary cilia for complete healing in mice.
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| Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron.
Marneros AG. Cell Rep. 2021 Jan 12;34(2):108616. doi: 10.1016/j.celrep.2020.108616. PMID: 33440155 Free PMC article. |
| Airway stem cells sense hypoxia and differentiate into protective solitary neuroendocrine cells.
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| PTHrP targets salt-inducible kinases, HDAC4 and HDAC5, to repress chondrocyte hypertrophy in the growth plate.
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| Impact of Zika virus on the human type I interferon osteoimmune response.
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| Sclerostin-Neutralizing Antibody Treatment Rescues Negative Effects of Rosiglitazone on Mouse Bone Parameters.
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| Effects of Combination Denosumab and High-Dose Teriparatide Administration on Bone Microarchitecture and Estimated Strength: The DATA-HD HR-pQCT Study.
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| Targeting Bone Cells During Sexual Maturation Reveals Sexually Dimorphic Regulation of Endochondral Ossification.
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| Effects of Sleeve Gastrectomy on Bone Marrow Adipose Tissue in Adolescents and Young Adults with Obesity.
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| Circulating testican-2 is a podocyte-derived marker of kidney health.
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| Single-Cell RNA Sequencing of Calvarial and Long-Bone Endocortical Cells.
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| Bone density, microarchitecture and strength estimates in white versus African American youth with obesity.
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| A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction.
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| Bone-Targeting AAV-Mediated Gene Silencing in Osteoclasts for Osteoporosis Therapy.
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| A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation.
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| Bone outcomes following sleeve gastrectomy in adolescents and young adults with obesity versus non-surgical controls.
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| Improved GPCR ligands from nanobody tethering.
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| Evolutionary Selection and Constraint on Human Knee Chondrocyte Regulation Impacts Osteoarthritis Risk.
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| At the Crossroads of the Adipocyte and Osteoclast Differentiation Programs: Future Therapeutic Perspectives.
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| Glycerol-3-phosphate is an FGF23 regulator derived from the injured kidney.
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| An Inverse Agonist Ligand of the PTH Receptor Partially Rescues Skeletal Defects in a Mouse Model of Jansen’s Metaphyseal Chondrodysplasia.
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| Effects of Estrogen Replacement on Bone Geometry and Microarchitecture in Adolescent and Young Adult Oligoamenorrheic Athletes: A Randomized Trial.
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| Sialyltransferase inhibition leads to inhibition of tumor cell interactions with E-selectin, VCAM1, and MADCAM1, and improves survival in a human multiple myeloma mouse model.
Natoni A, Farrell ML, Harris S, Falank C, Kirkham-McCarthy L, Macauley MS, Reagan MR, O’Dwyer M. Haematologica. 2020 Jan 31;105(2):457-467. doi: 10.3324/haematol.2018.212266. Print 2020. PMID: 31101754 Free PMC article. |
| Extra-Large Gα Protein (XLαs) Deficiency Causes Severe Adenine-Induced Renal Injury with Massive FGF23 Elevation.
Matthias J, Cui Q, Shumate LT, Plagge A, He Q, Bastepe M. Endocrinology. 2020 Jan 1;161(1):bqz025. doi: 10.1210/endocr/bqz025. PMID: 31758181 Free PMC article. |
Xie H, Bastepe I, Zhou W, Ay B, Ceraj Z, Portales-Castillo IA, Liu ES, Burnett-Bowie SM, Jüppner H, Rhee EP, Bastepe M, Simic P. 1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage. JCI Insight. 2023 Sep 8;8(17):e168957. doi: 10.1172/jci.insight.168957. PMID: 37681408; PMCID: PMC10544208.