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  • Leptin R. Tomato

    Lineage Tracing of bone marrow adipocytes showing a positive red tomato signal. (White arrows ) in green Lipitox stained adipocytes. Blue represents DAPI stained nuclei.

  • Composite RGB

    Immunostaining for CA3 (green) in osteocyclic cell line Ocy454. Blue represents DAPI stained nuclei.

  • Fura 2-Ca complex

    Fura-2 radiometric fluorescence assay of PTH-induced intracellular calcium signaling in HEK293/THR1 (GP-2.3) cells performed by the Cell Signaling Assay Core.

  • 3D Femur Trabecular Bone Reconstructions

    Representative 3D reconstructions of the trabecular bone in the distal femoral metaphysis of two genotypes of mice at four time points. This type of figure is great for demonstrating trabecular bone phenotypes in presentations and publications.

  • Osmium tetroxide staining for marrow adipose tissue analysis

    3D Reconstruction of the marrow adipose tissue (MAT) in the proximal and distal tibia of a control and treated mouse. The adipose tissue is stained with osmium tetroxide (dark grey in the images), which is radiopaque and can be images with µCT. Osmium tetroxide staining can be quantified with µCT to measure the effect of study parameters on MAT volume.

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Our Mission

The Center for Skeletal Research will further the discovery of the causes and therapies for skeletal diseases through the provision of core facilities and other programs designed to make the work of a broad group of investigators more efficient, interdisciplinary, innovative, and interactive. By making this research more effective, advances in understanding and therapy of osteoporosis and other bone disease will occur more quickly.

Research Cores

  • Bone Cells Services

    Bone Cells Services

    We provide high quality skeletally derived osteoblasts, osteoclasts, bone marrow stromal cells and osteocytes, as well as protocols and training for isolating, characterizing and isolating skeletally derived cells. We also develop novel techniques for isolating and studying bone cells.

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  • Bone RNAseq Core

    Bone RNAseq Core

    The RNA seq core will provide help and advice with designing of bulk tissue and single cell RNA sequencing experiments, help with tissue and cell preparation, access to space and equipment, expertise for performing bulk RNA extractions from bone and cartilage tissue and computational and statistical interpretation of RNA sequencing data.

    Learn More
  • Cell Signaling Assay Services

    Cell Signaling Assay Services

    Provides/Enables Assays for Cell Signaling Pathways
    cAMP, IP3, iCa, ERK-1/2, Multi-Array, 1,25 Dihydroxy Vitamin D, 25-Hydroxy Vitamin D, cAMP RIA, CTX-1,FGF-23, Fura-2 iCa++, Glosensor cAMP, IP1, P1NP, p-ERK-1/2, PTH.
    Formats: Luminescence, RIA, ELISA, HTRF
    Kit assays on a per-sample cost-basis.

    Learn More
  • Histology & Histomorphometry Services

    Histology & Histomorphometry Services

    Close interactions with the Imaging, Bone Cells and Signaling Cores will assure coordinated studies permitting imaging, histology, cell isolation, RNA and signaling analyses on skeletal elements from a single subject.

    Learn More
  • Imaging and Biomechanical Testing Services

    Imaging and Biomechanical Testing Services

    High-resolution micro-computed tomography (µCT) provides provides non-destructive, quantitative and qualitative assessment of trabecular and cortical bone microarchitecture.

    Learn More

Remember to acknowledge the Center for Skeletal Research if you received funding or services from our cores, see How to Cite P30.
P30 AR066261 – Core Services 2014 – May 31, 2019
P30 AR075042 – Core Services June 1, 2019 – May 31, 2024


Funded by P30 AR075042.

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The benefits of membership in P30 include subsidized rates in the CSR cores, experienced faculty to assist with projects, networking with other bone scientists, and much more.

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News

  • Research Technician Position at MGH Endocrine Unit, Marc Wein LaboratoryJanuary 2021 - 10:30 am

    A Research Technician position is open in Dr. Marc Wein’s laboratory in the MGH Endocrine Unit. Responsibilities include collection of and accurate recording of procedures and results, maintenance of databases used in the lab, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. This position requires a person who has […]

  • Summer Lecture Series RecordingsDecember 2020 - 2:43 pm

    Please follow these links to listen to the recordings of the CSR 2020 Summer Lecture Series “Bone cells and their functions” by Paola Divieti Pajevic, MD, PhD “Gene editing and cell signaling” by Marc Wein, M.D., Ph.D. and Kathy Tang “Osteoporosis and Space Flight Induced Bone Loss” by Mary Bouxsein, PhD “Vitamin D” by Marie […]

  • Postdoctoral Fellow Position – Evolutionary and Developmental Genetics Laboratory, Dr. Terence D. CapelliniDecember 2020 - 12:01 pm

    The Department of Human Evolutionary Biology at Harvard University invites applications for a Postdoctoral Fellow in the Evolutionary and Developmental Genetics Laboratory of Dr. Terence D. Capellini.  The focus of the position will be to study the genetic and developmental basis of human-specific adaptations and disease.  While the lab primarily concentrates on skeletal adaptations in […]

  • RESEARCH TECHNICIAN, BONE CELL CORE, Goldman School of Dental MedicineNovember 2020 - 4:09 pm

    Job Description The Bone Cell Core in the Department of Translational Dental Medicine, at H.Goldman School of Dental Medicine, Boston University has an opening for a part-time (20hrs/week) position for a Research technician. Bone Cells Core Technician will have the task of performing Core related tasks and completing services provided by the Bone Cell Core […]

Upcoming Events

  1. BU Department of Translational Dental Medicine Seminar Series

    March 3 @ 12:00 pm - 1:00 pm
  2. UCSF CCMBM Seminar Series

    March 9 @ 1:00 pm - 2:00 pm
  3. HSDM Science Speaker Series

    March 11 @ 12:00 pm - 1:00 pm

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Center for Skeletal Research
Endocrine Unit
Massachusetts General Hospital
50 Blossom Street, Thier 1101
Boston, MA 02114-2696

Telephone: 617-726-3967
Fax: 617-726-7543
Email: csrmail@partners.org

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