Publications

James S. Lyons, Humberto C. Joca, Robert A. Law, Katrina M. Williams, Jaclyn P. Kerr, Guoli Shi,4 Ramzi J. Khairallah, Stuart S. Martin, Konstantinos Konstantopoulos, Christopher W. Ward, Joseph P. Stains Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes Science Signaling

Wilk K, Yeh SA, Mortensen LJ, Ghaffarigarakani S, Lombardo CM, Bassir SH, Aldawood ZA, Lin CP, Intini G. Postnatal Calvarial Skeletal Stem Cells Expressing PRX1 Reside Exclusively in the Calvarial Sutures and Are Required for Bone Regeneration. Stem Cell Reports. 2017 Apr 11;8(4):933-946. doi: 10.1016/j.stemcr.2017.03.002. Epub 2017 Mar 30.

Silva PPB, Amlashi FG, Yu EW, Pulaski-Liebert KJ, Gerweck AV, Fazeli PK, Lawson E, Nachtigall LB, Biller BMK, Miller KK, Klibanski A, Bouxsein M, Tritos NA. Bone microarchitecture and estimated bone strength in men with active acromegaly. Eur J Endocrinol. 2017 Nov;177(5):409-420. doi: 10.1530/EJE-17-0468. Epub 2017 Aug 5.

Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B. Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017 Mar 7;25(3):661-672. doi: 10.1016/j.cmet.2017.01.001. Epub 2017 Feb 2. PubMed PMID: 28162969; PubMed Central

Kaludjerovic J, Komaba H, Sato T, Erben RG, Baron R, Olauson H, Larsson TE, Lanske B. Klotho expression in long bones regulates FGF23 production during renal failure. FASEB J. 2017 May;31(5):2050-2064. doi: 10.1096/fj.201601036R. Epub 2017 Feb 9. PubMed

Komaba H, Kaludjerovic J, Hu DZ, Nagano K, Amano K, Ide N, Sato T, Densmore MJ, Hanai JI, Olauson H, Bellido T, Larsson TE, Baron R, Lanske B. Klotho expression in osteocytes regulates bone metabolism and controls bone formation. Kidney Int. 2017 Sep;92(3):599-611. doi: 10.1016/j.kint.2017.02.014. Epub 2017 Apr 8. PubMed

Tokarz D, Martins JS, Petit ET, Lin CP, Demay MB, Liu ES. Hormonal Regulation of Osteocyte Perilacunar and Canalicular Remodeling in the Hyp Mouse Model of X-Linked Hypophosphatemia. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017

Saini V, Zhao H, Petit ET, Gori F, Demay MB. Absence of vitamin D receptor (VDR)-mediated PPARgamma suppression causes alopecia in VDR-null mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017;31(3):1059-66.

Roszko KL, Bi R, Gorvin CM, Brauner-Osborne H, Xiong XF, Inoue A, Thakker RV, Stromgaard K, Gardella T, Mannstadt M. Knockin mouse with mutant Galpha11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors. JCI insight. 2017;2(3):e91079. PMID: 28194446 PMCI: PMC5291736 associated with Shire/NPS Pharmaceuticals Inc. (USA), GlaxoSmithKline, Novartis Pharma AG, and Marshall-Smith Syndrome Foundation. KS is associated with Avilex Pharma (unrelated to this work).

Rolvien T, Krause M, Jeschke A, Yorgan T, Puschel K, Schinke T, Busse B, Demay MB, Amling M. Vitamin D regulates osteocyte survival and perilacunar remodeling in human and murine bone. Bone. 2017;103:78-87.

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB. Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. The Journal of biological chemistry. 2017;292(8):3164-71.

Lyons JS, Joca HC, Law RA, Williams KM, Kerr JP, Shi G, Khairallah RJ, Martin SS, Konstantopoulos K, Ward CW, Stains JP. Microtubules tune mechanotransduction through NOX2 and TRPV4 to decrease sclerostin abundance in osteocytes. Science signaling. 2017;10(506)

Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Juppner H, Bergwitz C. Response of Npt2a knockout mice to dietary calcium and phosphorus. PloS one. 2017;12(4):e0176232.

Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB. Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(4):814-20.

Knab VM, Corbin B, Andrukhova O, Hum JM, Ni P, Rabadi S, Maeda A, White KE, Erben RG, Juppner H, Christov M. Acute Parathyroid Hormone Injection Increases C-Terminal but Not Intact Fibroblast Growth Factor 23 Levels. Endocrinology. 2017;158(5):1130-9.

Kitano K, Schwartz DM, Zhou H, Gilpin SE, Wojtkiewicz GR, Ren X, Sommer CA, Capilla AV, Mathisen DJ, Goldstein AM, Mostoslavsky G, Ott HC. Bioengineering of functional human induced pluripotent stem cell-derived intestinal grafts. Nature communications. 2017;8(1):765.

Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN. Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(5):892-901.

He Q, Bouley R, Liu Z, Wein MN, Zhu Y, Spatz JM, Wang CY, Divieti Pajevic P, Plagge A, Babitt JL, Bastepe M. Large G protein alpha-subunit XLalphas limits clathrin-mediated endocytosis and regulates tissue iron levels in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(45):E9559-E68.

Guo J, Khatri A, Maeda A, Potts JT, Jr., Juppner H, Gardella TJ. Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(1):86-98.

Fulzele K, Lai F, Dedic C, Saini V, Uda Y, Shi C, Tuck P, Aronson JL, Liu X, Spatz JM, Wein MN, Divieti Pajevic P. Osteocyte-Secreted Wnt Signaling Inhibitor Sclerostin Contributes to Beige Adipogenesis in Peripheral Fat Depots. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2017;32(2):373-84.

Engblom C, Pfirschke C, Zilionis R, Da Silva Martins J, Bos SA, Courties G, Rickelt S, Severe N, Baryawno N, Faget J, Savova V, Zemmour D, Kline J, Siwicki M, Garris C, Pucci F, Liao HW, Lin YJ, Newton A, Yaghi OK, Iwamoto Y, Tricot B, Wojtkiewicz GR, Nahrendorf M, Cortez-Retamozo V, Meylan E, Hynes RO, Demay M, Klein A, Bredella MA, Scadden DT, Weissleder R, Pittet MJ. Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF(high) neutrophils. Science. 2017;358(6367)

Capellini TD, Chen H, Cao J, Doxey AC, Kiapour AM, Schoor M, Kingsley DM. Ancient selection for derived alleles at a GDF5 enhancer influencing human growth and osteoarthritis risk. Nat Genet. 2017;49(8):1202-10.

Caballero D, Li Y, Fetene J, Ponsetto J, Chen A, Zhu C, Braddock DT, Bergwitz C. Intraperitoneal pyrophosphate treatment reduces renal calcifications in Npt2a null mice. PloS one. 2017;12(7):e0180098.

Bragdon B, Lam S, Aly S, Femia A, Clark A, Hussein A, Morgan EF, Gerstenfeld LC. Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice. Bone. 2017;101:49-61.

Bornstein S, Moschetta M, Kawano Y, Sacco A, Huynh D, Brooks D, Manier S, Fairfield H, Falank C, Roccaro AM, Nagano K, Baron R, Bouxein M, Vary C, Ghobrial IM, Rosen CJ, Reagan MR. Metformin Affects Cortical Bone Mass and Marrow Adiposity in Diet-Induced Obesity in Male Mice. Endocrinology. 2017;158(10):3369-85.

Balani DH, Ono N, Kronenberg HM. Parathyroid hormone regulates fates of murine osteoblast precursors in vivo. J Clin Invest. 2017;127(9):3327-38.

Roszko KL, Bi R, Gorvin CM, Bräuner-Osborne H, Xiong XF, Inoue A, Thakker RV, Strømgaard K, Gardella T, Mannstadt M Knockin mouse with mutant Gα11 mimics human inherited hypocalcemia and is rescued by pharmacologic inhibitors JCI Insight. 2017;2(3):e91079

Leder BZ Parathyroid Hormone and Parathyroid Hormone-Related Protein Analogs in Osteoporosis Therapy. Curr Osteoporos Rep. 2017;15(2):110-119

Santoro N, Crawford SL, El Khoudary SR, Allshouse AA, Burnett-Bowie SA, Finkelstein J, Derby C, Matthews K, Kravitz HM, Harlow SD, Greendale GA, Gold EB, Kazlauskaite R, McConnell D, Neal-Perry G, Pavlovic J, Randolph J, Weiss G, Chen HY, Lasley B Menstrual Cycle Hormone Changes in Women Traversing the Menopause: Study Of Women’s Health Across the Nation. J Clin Endocrinol Metab. 2017;:ePub

Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Sci Transl Med. 2017;9(387):ePub

Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232

Qin Y, Peng Y, Zhao W, Pan J, Ksiezak-Reding H, Cardozo C, Wu Y, Divieti Pajevic P, Bonewald LF, Bauman WA, Qin W Myostatin Inhibits Osteoblastic Differentiation by Suppressing Osteocyte-derived Exosomal microRNA-218: A Novel Mechanism in Muscle-Bone Communication. J Biol Chem. 2017;292(26):11021-11033

Ikeda M, Kobayashi T, Suzuki T, Wakabayashi Y, Ohama Y, Maekawa S, Takahashi S, Homma Y, Tatsuno K, Sato T, Okugawa S, Moriya K, Yotsuyanagi H Propionimicrobium lymphophilum and Actinotignum schaalii bacteraemia: a case report. New Microbes New Infect. 2017;18:18-21

Kim SW, Lu Y, Williams EA, Lai F, Lee JY, Enishi T, Balani DH, Ominsky MS, Ke HZ, Kronenberg HM, Wein MN Sclerostin Antibody Administration Converts Bone Lining Cells Into Active Osteoblasts. J Bone Miner Res. 2017;32(5):892-901

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development. J Biol Chem. 2017;292(8):3164-3171

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232

Mitchell DM Growth in patients with type 1 diabetes. Curr Opin Endocrinol Diabetes Obes. 2017;24(1):67-72

Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice. J Bone Miner Res. 2017;32(4):814-820

Grigelioniene G, Nevalainen PI, Reyes M, Thiele S, Tafaj O, Molinaro A, Takatani R, Ala-Houhala M, Nilsson D, Eisfeldt J, Lindstrand A, Kottler ML, Mäkitie O, Jüppner H A Large Inversion Involving GNAS Exon A/B and All Exons Encoding Gsα Is Associated With Autosomal Dominant Pseudohypoparathyroidism Type Ib (PHP1B). J Bone Miner Res. 2017;32(4):776-783

Yao Q, Yu C, Zhang X, Zhang K, Guo J, Song L Wnt/β-catenin signaling in osteoblasts regulates global energy metabolism. Bone. 2017;97:175-183

Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Bilezikian JP, Dempster DW, Rosen CJ, Lanske B Parathyroid Hormone Directs Bone Marrow Mesenchymal Cell Fate. Cell Metab. 2017;25(3):661-672

Gardella TJ G-Protein-coupled receptors: Decoding mixed signals. Nat Chem Biol. 2017;13(3):247-248

Yu EW, Lee MP, Landon JE, Lindeman KG, Kim SC Fracture risk after bariatric surgery: Roux-en-Y gastric bypass versus adjustable gastric banding. J Bone Miner Res. 2017;:ePub

Leder BZ, Tsai JN, Jiang LA, Lee H Importance of prompt antiresorptive therapy in postmenopausal women discontinuing teriparatide or denosumab: The Denosumab and Teriparatide Follow-up study (DATA-Follow-up). Bone. 2017;98:54-58

Bulathsinhala L, Hughes JM, McKinnon CJ, Kardouni JR, Guerriere KI, Popp KL, Matheny RW, Bouxsein ML Risk of Stress Fracture Varies by Race/Ethnic Origin in a Cohort Study of 1.3 Million US Army Soldiers. J Bone Miner Res. 2017;:ePub

Mitchell DM, Jüppner H, Burnett-Bowie SM FGF23 Is Not Associated With Age-Related Changes in Phosphate, but Enhances Renal Calcium Reabsorption in Girls. J Clin Endocrinol Metab. 2017;102(4):1151-1160

Knab VM, Corbin B, Andrukhova O, Hum JM, Ni P, Rabadi S, Maeda A, White KE, Erben RG, Jüppner H, Christov M Acute parathyroid hormone injection increases c-terminal, but not intact fibroblast growth factor 23 levels. Acute parathyroid hormone injection increases c-terminal, but not intact fibroblast growth factor 23 levels.

Bi R, Fan Y, Luo E, Yuan Q, Mannstadt M Two Techniques to Create Hypoparathyroid Mice: Parathyroidectomy Using GFP Glands and Diphtheria-Toxin-Mediated Parathyroid Ablation. J Vis Exp. 2017;(121):ePub

Greenbaum A, Chan KY, Dobreva T, Brown D, Balani DH, Boyce R, Kronenberg HM, McBride HJ, Gradinaru V Bone CLARITY: Clearing, imaging, and computational analysis of osteoprogenitors within intact bone marrow. Sci Transl Med. 2017;9(387):ePub

Li Y, Caballero D, Ponsetto J, Chen A, Zhu C, Guo J, Demay M, Jüppner H, Bergwitz C Response of Npt2a knockout mice to dietary calcium and phosphorus. PLoS One. 2017;12(4):e0176232

Saini V, Zhao H, Petit ET, Gori F, Demay MB Absence of vitamin D receptor (VDR)-mediated PPARγ suppression causes alopecia in VDR-null mice. FASEB J. 2017;31(3):1059-1066

Amano K, Densmore M, Fan Y, Lanske B. Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones. Bone. 2016 Feb;83:256-66. doi: 10.1016/j.bone.2015.11.017. Epub 2015 Nov 24. PubMed

Yu EW, Carmody JS, Brooks DJ, LaJoie S, Kaplan LM, Bouxsein ML. Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass. Bone. 2016;85:23-8.

Xiong XF, Zhang H, Underwood CR, Harpsoe K, Gardella TJ, Woldike MF, Mannstadt M, Gloriam DE, Brauner-Osborne H, Stromgaard K. Total synthesis and structure-activity relationship studies of a series of selective G protein inhibitors. Nature chemistry. 2016;8(11):1035-41.

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKs control osteocyte responses to parathyroid hormone. Nature communications. 2016;7:13176. PMID: 27759007 PMCI: PMC5075806 receives grant support from Amgen, and has received consulting honorariums from Amgen and Novartis. M.B. receives grant support from Amgen and Merck, and serves on scientific advisory boards for Merck and Eli Lilly. T.S., R.X., H.M.K., and M.N.W. declare that patents have been filed for the therapeutic application of SIK inhibitors. The remaining authors declare no competing financial interests.

Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB. The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016;157(10):4066-75.

Shimizu M, Joyashiki E, Noda H, Watanabe T, Okazaki M, Nagayasu M, Adachi K, Tamura T, Potts JT, Jr., Gardella TJ, Kawabe Y. Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(7):1405-12.

Papaioannou G, Mirzamohammadi F, Kobayashi T. Ras signaling regulates osteoprogenitor cell proliferation and bone formation. Cell Death Dis. 2016;7(10):e2405.

O'Rourke C, Shelton G, Hutcheson JD, Burke MF, Martyn T, Thayer TE, Shakartzi HR, Buswell MD, Tainsh RE, Yu B, Bagchi A, Rhee DK, Wu C, Derwall M, Buys ES, Yu PB, Bloch KD, Aikawa E, Bloch DB, Malhotra R. Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation. J Vis Exp. 2016(111)

Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T. Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-beta signalling. Nature communications. 2016;7:12047.

Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B. A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. Journal of biomechanics. 2016;49(14):3549-54.

Liu ES, Raimann A, Chae BT, Martins JS, Baccarini M, Demay MB. c-Raf promotes angiogenesis during normal growth plate maturation. Development. 2016;143(2):348-55.

Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB. 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture, and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(5):929-39.

Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB. Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(12):2204-14.

Hattersley G, Dean T, Corbin BA, Bahar H, Gardella TJ. Binding Selectivity of Abaloparatide for PTH-Type-1-Receptor Conformations and Effects on Downstream Signaling Endocrinology. 2016;157(1):141-9.

Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC. Bioengineering Human Myocardium on Native Extracellular Matrix. Circulation research. 2016;118(1):56-72.

Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2016;30(1):428-40.

Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS. Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(6):1225-34.

Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification. Sci Transl Med. 2016;8(366):366ra163.

Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ. Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS chemical biology. 2016;11(10):2752-62.

Fan Y, Bi R, Densmore MJ, Sato T, Kobayashi T, Yuan Q, Zhou X, Erben RG, Lanske B. Parathyroid hormone 1 receptor is essential to induce FGF23 production and maintain systemic mineral ion homeostasis FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2015;30:428-40

Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury Endocrinology. 2016;157(10):4066-4075

Ko FC, Karim L, Brooks DJ, Bouxsein ML, Demay MB Bisphosphonate Withdrawal: Effects on Bone Formation and Bone Resorption in Maturing Male Mice J Bone Miner Res. 2016;32(4):814-820

Saini V, Zhao H, Petit ET, Gori F, Demay MB Absence of vitamin D receptor (VDR)-mediated PPARγ suppression causes alopecia in VDR-null mice FASEB J. 2016;31(3):1059-1066

Wein MN, Liang Y, Goransson O, Sundberg TB, Wang J, Williams EA, O'Meara MJ, Govea N, Beqo B, Nishimori S, Nagano K, Brooks DJ, Martins JS, Corbin B, Anselmo A, Sadreyev R, Wu JY, Sakamoto K, Foretz M, Xavier RJ, Baron R, Bouxsein ML, Gardella TJ, Divieti-Pajevic P, Gray NS, Kronenberg HM. SIKS control osteocyte responses to parathyroid hormone Nat Commun. 2016;7:13176

Dey D, Bagarova J, Hatsell SJ, Armstrong KA, Huang L, Ermann J, Vonner AJ, Shen Y, Mohedas AH, Lee A, Eekhoff EM, van Schie A, Demay MB, Keller C, Wagers AJ, Economides AN, Yu PB. Two tissue-resident progenitor lineages drive distinct phenotypes of heterotopic ossification Science Translational Medicine. 2016;8:366ra163

Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development J Biomech. 2016;49(14):3549-3554

Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease J Bone Miner Res. 2016;31(6):1225-34

Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass Bone. 2016;85:23-8

Liu ES, Martins JS, Raimann A, Chae BT, Brooks DJ, Jorgetti V, Bouxsein ML, Demay MB 1,25-Dihydroxyvitamin D Alone Improves Skeletal Growth, Microarchitecture and Strength in a Murine Model of XLH, Despite Enhanced FGF23 Expression J Bone Miner Res. 2016;31 (5):929-39

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB Raf Kinases are Essential for Phosphate Induction of Erk1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development J Biol Chem. 2017;292(8):3164-3171

Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment J Bone Miner Res. 2017;32(1):86-98

Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling Nat Commun. 2016;7:12047

Tsai JN, Burnett-Bowie SM, Lee H, Leder BZ Relationship between bone turnover and density with teriparatide, denosumab or both in women in the DATA study. Bone. 2016;95:20-25

Greenblatt MB, Tsai JN, Wein MN Bone Turnover Markers in the Diagnosis and Monitoring of Metabolic Bone Disease. Clin Chem. 2016;63(2):464-474

Putman MS, Yu EW, Lin D, Darakananda K, Finkelstein JS, Bouxsein ML Differences in Trabecular Microstructure Between Black and White Women Assessed by Individual Trabecular Segmentation Analysis of HR-pQCT Images. J Bone Miner Res. 2016;:ePub

Solomon DH, Diem SJ, Ruppert K, Lian YJ, Liu CC, Wohlfart A, Greendale GA, Finkelstein JS Bone mineral density changes among women initiating proton pump inhibitors or H2 receptor antagonists: a SWAN cohort study J Bone Miner Res. 2015;30(2):232-9

Tafaj O, Jüppner H Pseudohypoparathyroidism: one gene, several syndromes. J Endocrinol Invest. 2016;40(4):347-356

Song L, Papaioannou G, Zhao H, Luderer HF, Miller C, Dall'Osso C, Nazarian RM, Wagers AJ, Demay MB The Vitamin D Receptor Regulates Tissue Resident Macrophage Response to Injury. Endocrinology. 2016;157(10):4066-4075

Miranda DL, Putman M, Kandah R, Cubria M, Suarez S, Nazarian A, Snyder B A pediatric animal model to evaluate the effects of disuse on musculoskeletal growth and development. J Biomech. 2016;49(14):3549-3554

Cheloha RW, Watanabe T, Dean T, Gellman SH, Gardella TJ Backbone Modification of a Parathyroid Hormone Receptor-1 Antagonist/Inverse Agonist. ACS chemical biology. 2016;11(10):2752-62.

Popp KL, Hughes JM, McKinnon CJ, Kardouni JR, Matheny RW, Bouxsein ML Ethinyl Estradiol-Containing Hormonal Contraceptive Prescriptions are Associated with Reduced Stress Fracture Risk in Female Soldiers: 3096 Board #161 June 3, 3: 30 PM – PM.5: 00 Med Sci Sports Exerc. 2016;48(5 Suppl 1):878

Hughes JM, Popp KL, Yanovich R, Bouxsein ML, Matheny RW The role of adaptive bone formation in the etiology of stress fracture. Exp Biol Med (Maywood). 2016;242(9):897-906

Shimizu M, Joyashiki E, Noda H, Watanabe T, Okazaki M, Nagayasu M, Adachi K, Tamura T, Potts JT, Gardella TJ, Kawabe Y Pharmacodynamic Actions of a Long-Acting PTH Analog (LA-PTH) in Thyroparathyroidectomized (TPTX) Rats and Normal Monkeys. J Bone Miner Res. 2016;31(7):1405-12

Stevenson HP, Lin G, Barnes CO, Sutkeviciute I, Krzysiak T, Weiss SC, Reynolds S, Wu Y, Nagarajan V, Makhov AM, Lawrence R, Lamm E, Clark L, Gardella TJ, Hogue BG, Ogata CM, Ahn J, Gronenborn AM, Conway JF, Vilardaga JP, Cohen AE, Calero G Transmission electron microscopy for the evaluation and optimization of crystal growth. Acta Crystallogr D Struct Biol. 2016;72(Pt 5):603-15

Nampoothiri S, Fernández-Rebollo E, Yesodharan D, Gardella TJ, Rush ET, Langman CB, Jüppner H Jansen Metaphyseal Chondrodysplasia due to heterozygous H223R-PTH1R mutations with or without overt hypercalcemia. J Clin Endocrinol Metab. 2016;:jc20162054

Brandi ML, Bilezikian JP, Shoback D, Bouillon R, Clarke BL, Thakker RV, Khan AA, Potts JT Management of Hypoparathyroidism: Summary Statement and Guidelines. J Clin Endocrinol Metab. 2016;101(6):2273-83

Clarke BL, Brown EM, Collins MT, Jüppner H, Lakatos P, Levine MA, Mannstadt MM, Bilezikian JP, Romanischen AF, Thakker RV Epidemiology and Diagnosis of Hypoparathyroidism. J Clin Endocrinol Metab. 2016;101(6):2284-99

Putman MS, Greenblatt LB, Sicilian L, Uluer A, Lapey A, Sawicki G, Gordon CM, Bouxsein ML, Finkelstein JS Young adults with cystic fibrosis have altered trabecular microstructure by ITS-based morphological analysis. Osteoporos Int. 2016;27(8):2497-505

Ono W, Sakagami N, Nishimori S, Ono N, Kronenberg HM Parathyroid hormone receptor signalling in osterix-expressing mesenchymal progenitors is essential for tooth root formation. Nat Commun. 2016;7:11277

Leder BZ, Tsai JN, Burnett-Bowie SA, Bouxsein ML, Neer RM Letter to the editor in response to the commentary, "Concurrent administration of PTH and antiresorptives: Additive effects or DXA cosmetics. Bone. 2016;89:73-4

Poradosu S, Bravenboer B, Takatani R, Jüppner H Pseudohypoparathyroidism type 1B caused by methylation changes at the GNAS complex locus. BMJ Case Rep. 2016;2016:ePub

Shanbhogue VV, Finkelstein JS, Bouxsein ML, Yu EW Association Between Insulin Resistance and Bone Structure in Nondiabetic Postmenopausal Women. J Clin Endocrinol Metab. 2016;101(8):3114-22

Ko FC, Martins JS, Reddy P, Bragdon B, Hussein AI, Gerstenfeld LC, Demay MB Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice. J Bone Miner Res. 2016;31(12):2204-2214

Mirzamohammadi F, Papaioannou G, Inloes JB, Rankin EB, Xie H, Schipani E, Orkin SH, Kobayashi T Polycomb repressive complex 2 regulates skeletal growth by suppressing Wnt and TGF-β signalling. Nat Commun. 2016;7:12047

Ono N, Kronenberg HM Bone repair and stem cells. Curr Opin Genet Dev. 2016;40:103-107

Guo J, Khatri A, Maeda A, Potts JT, Jüppner H, Gardella TJ Prolonged Pharmacokinetic and Pharmacodynamic Actions of a Pegylated Parathyroid Hormone (1-34) Peptide Fragment. J Bone Miner Res. 2016;32(1):86-98

Eda H, Santo L, Wein MN, Hu DZ, Cirstea DD, Nemani N, Tai YT, Raines SE, Kuhstoss SA, Munshi NC, Kronenberg HM, Raje NS Regulation of Sclerostin Expression in Multiple Myeloma by Dkk-1: A Potential Therapeutic Strategy for Myeloma Bone Disease. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2016;31(6):1225-34

Yu EW, Carmody JS, Brooks DJ, LaJoie S, Kaplan LM, Bouxsein ML Cortical and trabecular deterioration in mouse models of Roux-en-Y gastric bypass. Bone. 2016;85:23-8

Leder BZ, Tsai JN, Neer RM, Uihlein AV, Wallace PM, Burnett-Bowie SM Response to Therapy With Teriparatide, Denosumab, or Both in Postmenopausal Women in the DATA (Denosumab and Teriparatide Administration) Study Randomized Controlled Trial. J Clin Densitom. 2016;19(3):346-51

Leaf DE, Christov M, Jüppner H, Siew E, Ikizler TA, Bian A, Chen G, Sabbisetti VS, Bonventre JV, Cai X, Wolf M, Waikar SS Fibroblast growth factor 23 levels are elevated and associated with severe acute kidney injury and death following cardiac surgery. Kidney Int. 2016;89(4):939-48

Ikeda S, Okamoto T, Okano S, Umemoto Y, Tagawa T, Morodomi Y, Kohno M, Shimamatsu S, Kitahara H, Suzuki Y, Fujishita T, Maehara Y PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non-Small Cell Lung Cancer. J Thorac Oncol. 2016;11(1):62-71

Kronenberg HM Bone and Mineral Metabolism: Where Are We, Where Are We Going, and How Will We Get There? J Clin Endocrinol Metab. 2016;101(3):795-8

Sinha P, Aarnisalo P, Chubb R, Poulton IJ, Guo J, Nachtrab G, Kimura T, Swami S, Saeed H, Chen M, Weinstein LS, Schipani E, Sims NA, Kronenberg HM, Wu JY Loss of Gsα in the Postnatal Skeleton Leads to Low Bone Mass and a Blunted Response to Anabolic Parathyroid Hormone Therapy. J Biol Chem. 2015;291(4):1631-42

Kozhemyakina E, Zhang M, Ionescu A, Ayturk UM, Ono N, Kobayashi A, Kronenberg H, Warman ML, Lassar AB. Identification of a Prg4-expressing articular cartilage progenitor cell population in mice. Arthritis Rgenatol.. 2015;67:1261-73

Guyette JP, Charest JM, Mills RW, Jank BJ, Moser PT, Gilpin SE, Gershlak JR, Okamoto T, Gonzalez G, Milan DJ, Gaudette GR, Ott HC Bioengineering Human Myocardium on Native Extracellular Matrix. Circulation research. 2016;118(1):56-72.