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The Center for Multiscale & Translational Mechanobiology currently has one full-time Postdoctoral Research Fellow position open with a start date of summer 2021.  Postdoctoral fellow positions are open to individuals who have received a doctoral degree or equivalent.  Candidates are expected to have a proven publication record and the ability to work both independently and as part of a team.

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The Bajpayee lab at Northeastern University in Boston is looking for candidates with interest and expertise in chemical conjugation, peptide design and synthesis, particle formulation, drug delivery and animal studies. We are looking for highly motivated and independent researchers to carry out work in design of electrically charged protein, peptide and exosome based nanocarriers, drug conjugation, modeling transport properties in tissue culture models, examining the pharmacokinetics, biodistribution and tissue targeting efficacy of drugs in injury induced animal models of osteoarthritis. Experience in the following technical areas is preferred: rodent traumatic models of osteoarthritis, small animal surgery and in vivo imaging, molecular and cell biology, flow cytometry and FACS,and immunohistochemistry and imaging.

For post-doc position, prior experience in orthopedic labs and in-vivo models is desired. Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic multi-disciplinary team environment. Applicants with a strong training background and publication track record in material synthesizes, drug delivery or cartilage biology are highly encouraged to apply.

This is an ideal position for someone looking for experience in translational research to train for both academia and industry. Please email your CV with names of three references to a.bajpayee@neu.edu

About Bajpayee lab: (more at https://web.northeastern.edu/bajpayeelab/)
Bajpayee lab works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Their dense extracellular matrix, however, hinders penetration of most drugs. We utilize concepts of nanomedicine and bio-electrostatics to design polypeptides, protein and cell derived exosomebased carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. We are also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The lab strives to combine basic science with translational research to develop biomedical technologies. Our Lab is highly interdisciplinary and collaborative with established collaborations with Harvard Medical School, MIT,BUMC and MGH.

Postdoctoral Position: Click here to download description

POSITION

Postdoctoral position available to study epigenetic control of skeletal development

GENERAL SUMMARY/OVERVIEW STATEMENT

Postdoctoral position is available in the laboratory of Dr. Diana Carlone, Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School. My laboratory is investigating the role of epigenetics in limb mesenchymal progenitor cell differentiation during endochondral ossification. We have identified a factor that is crucial for the initial stages of chondrogenesis and also for growth plate development. The focus of this position is to determine the interplay between this newly identified factor and the gene regulatory network and molecular mechanisms that control skeletal development. This project was recently funded by NIAMS.

EDUCATION AND EXPERIENCE REQUIRED

The applicant must have a PhD, MD or MD/PhD degree. We seek a highly motivated, organized and reliable person who can work independently with strong written and oral communication skills. This project involves the use of genetically engineered mice, histological analyses and culture of primary cells and cell lines. Prior experience in limb and skeletal development and/or large scale data analysis, specifically ChIP-seq and RNA-seq, is a plus.

APPLICATION REQUIREMENTS

To apply for this position, please email a cover letter and C.V. to:

Dr. Diana Carlone, Ph.D.

Diana.carlone@childrens.harvard.edu

The Clinical Orthopedic and Musculoskeletal Education and Training Program (COMET) is an NIH-funded T32 training program based at Brigham and Women’s Hospital and Harvard Medical School. COMET is intended to train highly qualified pre- and post-doctoral trainees in rigorous clinical research methods to address pressing problems relating to orthopedic and musculoskeletal disorders.  The range of methodologies suitable for support is wide, including epidemiology, biostatistics, economics, pharmaco-epidemiology, policy modeling, decision making and decision analysis among others.  The range of substantive topics is similarly wide, encompassing orthopedic surgical interventions and disorders affecting the musculoskeletal system including, but not limited to, osteoarthritis, osteoporosis, spinal disorders, regional musculoskeletal disorders, tendon, ligament and other soft tissue conditions, and musculoskeletal pain.  The research must be carried out on humans.  Research focused on inflammatory disorders (such as rheumatoid arthritis) are appropriate if the research specifically involves orthopedic interventions or musculoskeletal manifestations such as osteoporosis and fracture.

Per NIH guidelines, applicants must be citizens of the United States or have been lawfully admitted for permanent residence at the time of appointment.  Underrepresented minority groups including are strongly encouraged to apply.

Trainees accepted for the program will be funded, in general, for two years, conditional on a progress report at the end of the first year.  The training grant covers salary or stipend, travel to professional meetings, and other training-related expenses.  The postdoctoral award will cover 60% of tuition for the Program in Clinical Effectiveness at Harvard School of Public Health (up to ~16K/year).  The predoctoral award includes a stipend for 60% of tuition for PhD candidates up to ~16K/year.  Applicants must be nominated by a mentor who is an independently funded investigator.  One or more COMET program core faculty members must be involved in the trainee’s work.

We are accepting applications for slots beginning in July 2020. Please see the URL below for more information about the program and for application materials.  

http://oracore.bwh.harvard.edu/careers-training/training-opportunities/comet-position/