Archive for category: News

Open Position: Tenure Track Position – Translational Research in Bone/Joint Healing

/in /by

Click here for details and application

JOB DESCRIPTION

Wake Forest University School of Medicine invites applications to fill an open rank, tenure track position with an individual conducting translational research focused on the prevention and treatment of infection, healing and repair of bone, joints, and soft tissue management. The candidate will collaborate closely with national leaders in orthopaedic research, with particular interest in orthopaedic trauma, periprosthetic infection, and regenerative medicine. The Atrium Health Musculoskeletal Institute has strong clinical programs in musculoskeletal care, including orthopaedic surgery, primary care sports medicine, physical therapy.  We are particularly interested in those working in the areas of:

  • 1. Surgical site and periprosthetic infection: prevention and treatment
  • 2  Soft tissue management and healing (muscle, skin, wounds)
  • 3. Bone and cartilage healing
  • 4. Innovative treatments to promote healing

Wake Forest University School of Medicine has a highly collaborative, research intensive faculty and offers a dynamic environment for cutting edge multidisciplinary research. The rich collaborative environment includes many  nationally recognized research entities including: the Sticht Center for Healthy Aging and Alzheimer’s Prevention, two NIA funded centers (Claude D. Pepper Older Americans Independence Center, Alzheimer’s Disease Research Center), the Division of Public Health Sciences, an NCI-funded Comprehensive Cancer Center, the Wake Forest Institute for Regenerative Medicine (WFIRM), the Center for Precision Medicine, and the WFU Primate facility which houses a breeding colony that includes aged animals. Additional information is available at https://school.wakehealth.edu.

Applicant Qualifications: Candidates should hold a PhD, MD or equivalent degree in a relevant field. In addition to growing and maintaining a robust, internationally recognized research program and working in a team science environment across the translational spectrum, successful candidates will be expected to contribute to teaching and mentoring of students/trainees and to support an inclusive culture that welcomes diversity of experience and thought. Start-up package, laboratory space, salary and rank will be commensurate with experience. Applicants will be appointed to the department best aligning with their program.

Applying: Applicants should submit (1) a letter with statement of interest, (2) a complete curriculum vitae, and (3) a description of their current/future research program via the online application system.  Application materials may also be emailed to T.K. at tkhounth@wakehealth.edu. 

The Wake Forest University School of Medicine (WFUSM) is a U.S. News and World Report top 50 ranked medical school.  WFUSM has over $300M in annual, extramural funding that drives a cutting-edge Academic Learning Health System by integrating innovative research with excellent patient care across our enterprise. 

The WFUSM serves as the academic core for Advocate Health – the 5th largest non-profit health system in the U.S.  Our Enterprise serves over 6 million patients with facilities in seven states across the Southeast and Midwest (AL, GA, IL, NC, SC, WS). Headquartered in Charlotte, NC, Advocate Health  employs nearly 150,000 team members across 67 hospitals and over 1,000 care locations; offers one of the nation’s largest graduate medical education programs with over 2,000 residents and fellows across more than 200 programs; and is committed to equitable care for all providing nearly $5 billion in annual community benefits. 

Our highly integrated academic and clinical environment is deeply committed to improve health, elevate hope, and advance healing – for all.   WFUSM is home to nationally- and internationally-recognized research in Alzheimer’s Disease, Aging and Mobility, Cardiovascular Disease, Diabetes and Obesity, Cancer, Neurosciences, and Regenerative Medicine. Research excellence, coupled with a robust Informatics data infrastructure, clinically integrated implementation science efforts, and a firm commitment to the promotion of health equity renders the WFUSM a rich environment for breakthroughs in prevention, diagnosis, and treatment of disease and improvements in quality of life.  We are in a phase of unprecedented growth and evolution, opening a second medical school campus in Charlotte, and recruiting over 40 new research-intensive faculty to bolster our commitment to growing our Academic Learning Health System. 

***Advocate Health/Wake Forest University School of Medicine does not discriminate on the basis of race, color, religion, national origin, age, sex, sexual orientation, gender identity, gender expression, disability, or source of payment. 

Culture Commitments

We create a space where all Belong

We Work as One to make great things happen

We earn Trust in all we do

We Innovate to better the now and create the future

We drive for Excellence – always

WFUSOM-1

CORT Pilot & Feasibility Award

/in /by

CORT Pilot & Feasibility Award

Click here to download RFA

The Center of Research Translation on Osteoporosis Bone Anabolic Therapies (CORT), based in the Endocrine Unit at MGH, and funded by the National Institute of Arthritis and Musculoskeletal Diseases (NIAMS) P50 mechanism is announcing a request for Pilot and Feasibility Research proposals ($30,000/year direct costs plus 15% indirect costs). This announcement is directed to faculty proposing highly focused research projects that address mechanisms of action of osteoporosis bone anabolic therapies using preclinical or clinical models. Specifically, pilot and feasibility funding is encouraged to be used to support development of novel technologies that contribute to this goal. Awardees will be expected to present progress to CORT members biannually and provide a written annual report.

 

LETTER OF INTENT DUE: FRIDAY, SEPT 13th at 5PM EST

 

Letter of intent should include:

  • A 250-word abstract
  • NIH style biosketch
  • other support page

Please submit in a single PDF file to dafitzgerald@mgb.org. In subject line, include your last name and “P50P+F LOI”.

 

 

THOSE INVITED TO APPLY FOR FUNDING WILL BE INFORMED BY FRIDAY, SEPT 27TH     

 

APPLICATIONS WILL BE DUE ON OCT 25TH AT 5PM EST.

Investigators must invest at least 0.5 calendar months of effort.  If salary requests do not reflect this effort, cost-sharing plans must be indicated. Applicants who are not U.S. citizens or permanent U.S. residents must have active visas permitting them to remain in the U.S. for the full period of the proposed research.

Per NIAMS rules, interventional clinical studies are not allowed.

Previous P50 P&F awardees will be allowed to re-apply for an additional year of funding.

Open Position: Research Lab Technician – Bastepe, Jueppner, Gardella labs

/in /by

A Research Laboratory Technician I position is available in the laboratories of Drs. Murat Bastepe, Harald Jueppner, and Thomas Gardella in the Endocrine Unit at the Massachusetts General Hospital. This is a full-time 40 hour/week position.  Experience with basic laboratory techniques in the setting of a research experience or undergraduate biochemistry/molecular biology lab, e.g., sterile cell culture techniques and basic molecular biology techniques–such as plasmid purification, gel electrophoresis, and PCR, generation and staining of histological sections from bone, kidney and possibly other organs. Ability to build upon these techniques, learning new ones as necessary, to conduct the research project.

To read the full job description and apply, please visit:

https://partners.taleo.net/careersection/ghc/jobdetail.ftl?job=3295180&tz=GMT-04%3A00&tzname=America%2FNew_York

Research Technician Job ID 3295180

Opportunity: CSR Outstanding Manuscript Award

/in /by

CSR Outstanding Manuscript Award

 

The Center for Musculoskeletal Research is delighted to announce an Outstanding Manuscript Award to be given to a First Author performing investigation in musculoskeletal research. This award is intended for an Assistant Professor, Instructor, or Post-Doctoral Fellow who has made a significant contribution as first author of a manuscript. The award will be announced at our Annual Musculoskeletal Research Symposium on April 28, 2025.

Eligibility: Manuscripts must be published between January 1, 2024 and December 31, 2024 that acknowledge P30 support and have been submitted to the CSRmail@partners.org by January 31, 2025.

Open Position: Postdoctoral Fellow, UMass Med; Sato Lab

/in /by

The Sato Lab at UMass Med, starting June 1st, is seeking an enthusiastic postdoctoral fellow to join our team at the forefront of gene editing and cell therapy research. Our research group is at the forefront of cutting-edge science, focusing on elucidating the molecular mechanisms underlying rare diseases and autoimmune disorders. Through innovative approaches such as gene editing and cell therapy, we aim to develop novel therapeutic strategies to combat these conditions and improve patient outcomes.

Project Highlights:

  • Utilize cutting-edge CRISPR gene editing techniques
  • Engineer and explore cell therapies for disease treatment
  • Investigate the genetic basis of rare skeletal and connective tissue diseases
  • Unravel mechanisms underlying autoimmune disorders

Qualifications (Postdoctoral Fellow):

  • D. in Genetics, Cell Biology, skeletal biology, or a related field
  • Experience with gene editing techniques (CRISPR preferred)
  • Strong background in cell culture and in vitro assays
  • Excellent collaborative skills with multidisciplinary teams to design and execute experiments.

How to Apply:

Interested candidates should submit a CV or resume, a cover letter with a short description outlining research interests and relevant experience, and contact information for three references to tadatoshi.sato@umassmed.edu. Please indicate the position you are applying for in the subject line.

Open Position: Research Technician, UMass Med; Sato Lab

/in /by

The Sato Lab at UMass Med, starting June 1st, is seeking an enthusiastic research technician to join our team at the forefront of gene editing and cell therapy research. Our research group is at the forefront of cutting-edge science, focusing on elucidating the molecular mechanisms underlying rare diseases and autoimmune disorders. Through innovative approaches such as gene editing and cell therapy, we aim to develop novel therapeutic strategies to combat these conditions and improve patient outcomes.

Project Highlights:

  • Utilize cutting-edge CRISPR gene editing techniques
  • Engineer and explore cell therapies for disease treatment
  • Investigate the genetic basis of rare skeletal and connective tissue diseases
  • Unravel mechanisms underlying autoimmune disorders

Qualifications (Research Technician):

  • Bachelor’s degree in Biology or a related field
  • Experience in a laboratory setting
  • Strong attention to detail and excellent organizational skills

How to Apply:

Interested candidates should submit a CV or resume, a cover letter with a short description outlining research interests and relevant experience, and contact information for three references to tadatoshi.sato@umassmed.edu. Please indicate the position you are applying for in the subject line.

Open Position: University of Texas Southwestern Medical Center; Jialiang Wang Lab

/in /by

The Charles and Jane Pak Center for Mineral Metabolism and Clinical Research (CMMCR) at UT Southwestern Medical Center is seeking highly motivated Postdoctoral Research Fellow (1) and Research Technician (1) in the newly opening Dr. Jialiang (Shirley) Wang laboratory. Dr. Wang’s postdoctoral research was done at Massachusetts General Hospital and Harvard Medical University, where her work utilized multi-omics approaches to investigate skeletal disease and bone health. She is a recipient of the NIH Pathways to Independence Award (K99/R00).

 

Wang laboratory will take an interdisciplinary approach that spans genetics, multi-omics, in vivo and in vitromodels, to characterize how aberrant factors can lead to skeletal disease and bone cancer. Previous and ongoing work 1) investigates the molecular program that regulates osteocytogenesis and bridges the gap between osteocyte development and human skeletal disease, and 2) reveals the regulatory role of transcription factors in bone cancer and develops novel transcription factor-targeted therapies. There are many exciting projects to work on and these projects will provide the opportunity to receive close mentorship and learn cutting-edge technologies, such as CRISPR-Cas9 gene editing, single-cell RNA-seq, spatial transcriptome and multi-omics analysis. We are very open to new ideas and support the scientific and career development of lab members.

 

The research in Wang laboratory involves close collaboration with diverse scientists, clinicians, and members of the integrated multidisciplinary research environment within the CMMCR and across UT Southwestern. We value diversity in backgrounds and experience. We believe that diversity drives creativity and innovation, and we are dedicated to fostering an inclusive ecosystem where individual differences in academic, cultural and professional backgrounds are celebrated and respected.

 

Candidates with a PhD (MD or MD/PhD) degree in the biological and biomedical science and research experience in genetics, genomics, developmental and molecular biology, endocrinology or tumor biology should submit a C.V., a Cover Letter and names/emails of 3 references via email to:  jialiang.wang@utsouthwestern.edu.

Open Position: Research Scientist; Dr. Andreia Ionescu lab at Northeastern University

/in /by

Position: Research Scientist in the laboratory of Dr. Andreia Ionescu at Northeastern University. Research in Dr. Ionescu’ s laboratory focuses on cartilage and bone stem cell driven regeneration using mouse models. The successful candidate will support projects investigating the molecular mechanisms of osteoarthritis and epiphyseal cartilage regeneration, as well as helping with general daily laboratory upkeep tasks. The position involves a substantial amount of mouse work as well as mammalian cell culture, general biochemistry and molecular biology techniques, flow cytometry and RNAseq / ATACseq.

 

 

Education and Experience:

This position requires a Ph.D. The qualified applicant must have proven experience in one or more of the following areas: stem cell biology, skeletal biology, developmental biology. Research experience with mouse husbandry / surgery, in vitro cell culture of stem cells, flow cytometry and RNAseq (single cell and bulk) analysis highly desired.

 

Duties and responsibilities include, but are not limited to, the following: use of the following molecular biology techniques: qPCR, mammalian tissue culture with established lines and primary stem cells, flow cytometry, biochemical assays, histology, immunohistochemistry, laser capture microscopy. Performance of rodent work, including the following: husbandry, breeding, colony maintenance, genotyping, small animal surgery, euthanasia and tissue collection.

 

The incumbent will also be responsible for organizing, processing, and reporting data.

Will demonstrate flexibility in adapting methods/skills according to evolving project priorities.Provide independent experimental design and follow up planning, interpretation of results and evaluation of data. Able to analyze and interpret data from different sources and draw relevant conclusions. Demonstrate knowledge in specialized disciplines. Will also be expected to participate and present in regular lab meetings.

 

High level of initiative and motivation preferred; ability to work independently and with a team preferred; excellent communication, organization, time management, and record-keeping skills preferred. The candidate must have extremely high standards in terms of quality of work, attention to detail, strong organization skills, and absolute commitment to task completion. He or she must be able to balance multiple tasks and shifting priorities under tight deadlines at an accelerated pace when necessary; proven ability to work independently and creatively; and strong skills in written English, demonstrated in examples such as prior research writing. Contributes to writing of reports and manuscripts, with increasing responsibility over time. Works collaboratively across functions. Trains junior members of team as needed.

For additional information about the Ionescu lab, please visit: https://ionesculab.sites.northeastern.edu/

 

Job Type: Full-time

Salary: $55,000.00 – $80,000.00 per year

Benefits: Northeastern University 401(k), health insurance, etc

Clinical Phenotyping Core Mini-grant RFA

/in /by

Clinical Phenotyping Core Mini-grant RFA

 

Mini-grants of up to $10,000 are available to support the acquisition of critical preliminary data for grant submission or the use of clinical phenotyping to support existing work for a manuscript submission.  Funds must be used for services provided by the Clinical Phenotyping Core (CPC; https://csr-mgh.org/cores/clinical-phenotyping-core-2/).  Awarded funds will cover essential efforts at the CPC including personnel support for conducting the analyses. Please contact Dr. Ata Kiapour (ata.kiapour@childrens.harvard.edu) to discuss opportunities and advantages to using CPC services to support your ongoing and future research programs.

 

Examples of potential services include:

  • 2D and 3D phenotyping of bony and soft tissue structures (e.g., bone shape, cartilage thickness) using clinically relevant measurement techniques to mimic clinical evaluations.
  • Quantitative image analysis (e.g., T2 mapping) to assess tissue quality (e.g., cartilage and ligament) from imaging data.
  • Deep phenotyping (e.g., 3D mapping) to study complex morphologies.
  • Imaging biomarker identification to predict the risk of injury or treatment outcomes.
  • Genotype-phenotype matching of pre-clinical models (e.g., genetically modified mouse models) to clinical cohorts (e.g., patients with certain musculoskeletal disorders) to help better interpret and validate the preclinical observations.

Submissions that benefit from the use of more than one of the CSR Cores are welcome.

 

Applications must include:

  1. NIH style biosketch with other support pages.
  2. For applications related to collection of preliminary data for a future grant proposal please include:
    • Title, Specific Aims, funding deadline (must be within a year), agency to which grant is being submitted and type of proposal (R21, R01 etc)
  3. For applications related to the use of clinical phenotyping to support existing work for a manuscript submission please include:
    • A description of the study, hypotheses, conducted experiments, collected outcomes, target journal and submission date (should be within 6 months).
  4. A brief description (300 words limit) of the study design and why the investigations to be supported by the Core grant are critical for the grant proposal or the publication.
  5. For post-docs, a letter from the current mentor must be included indicating:
    • the studies proposed will support funding for the applicant’s independence
    • plans for the applicant’s transition to independence.
  6. Budget, based on consultation with relevant Core director(s).

 

 

Directed Differentiation Core Mini Grant RFA

/in /by

Mini-grants of up to $10,000 are available to support the acquisition of critical preliminary data for grant submission. Funds must be used for services provided by the Directed Differentiation Core (DDC). Awarded funds will cover essential lot-tested cell culture reagents and consumables in the core, and other associated experimental costs. Please contact Dr. April Craft (april.craft@childrens.harvard.edu) to discuss opportunities and advantages to using DDC services to support your ongoing and future research programs.

Examples of potential services include using pluripotent stem cell models to validate gene, protein or signaling pathway function, evaluating the differentiation potential of genetically-modified cells, proof-of-concept that desired cell type(s) can be produced from a cell line of interest, production of developmentally-relevant cells for -omics analyses, training to establish primary mouse cell cultures (i.e., limb bud micromass), training and support to generate a clonal mouse ESC reporter line, development of a relevant cell culture assay to test investigator initiated hypotheses. Submissions that benefit from the use of more than one of the CSR Cores are welcome (i.e., the RNA sequencing and Spatial Transcriptomic Core, Musculoskeletal Cell Core).

Applications must include:

1. NIH style biosketch with other support pages.
2. Title, Specific Aims, funding deadline (must be within 6 months), agency to which grant is being submitted and type of proposal (R21, R01 etc)
3. A brief description (300 words limit) of the experimental plan and why the investigations to be supported by the Core grant are critical for the grant proposal.
4. For post-docs, a letter from the current mentor must be included indicating:
….. – the studies proposed will support funding for the applicant’s independence
….. – plans for the applicant’s transition to independence.
5. Budget, based on consultation with relevant Core director(s).