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The Clinical Orthopedic and Musculoskeletal Education and Training Program (COMET) is an NIH-funded T32 training program based at Brigham and Women’s Hospital and Harvard Medical School. COMET is intended to train highly qualified pre- and post-doctoral trainees in rigorous clinical research methods to address pressing problems relating to orthopedic and musculoskeletal disorders.  The range of methodologies suitable for support is wide, including epidemiology, biostatistics, economics, pharmaco-epidemiology, policy modeling, decision making and decision analysis among others.  The range of substantive topics is similarly wide, encompassing orthopedic surgical interventions and disorders affecting the musculoskeletal system including, but not limited to, osteoarthritis, osteoporosis, spinal disorders, regional musculoskeletal disorders, tendon, ligament and other soft tissue conditions, and musculoskeletal pain.  The research must be carried out on humans.  Research focused on inflammatory disorders (such as rheumatoid arthritis) are appropriate if the research specifically involves orthopedic interventions or musculoskeletal manifestations such as osteoporosis and fracture.

Per NIH guidelines, applicants must be citizens of the United States or have been lawfully admitted for permanent residence at the time of appointment.  Underrepresented minority groups including are strongly encouraged to apply.

Trainees accepted for the program will be funded, in general, for two years, conditional on a progress report at the end of the first year.  The training grant covers salary or stipend, travel to professional meetings, and other training-related expenses.  The postdoctoral award will cover 60% of tuition for the Program in Clinical Effectiveness at Harvard School of Public Health (up to ~16K/year).  The predoctoral award includes a stipend for 60% of tuition for PhD candidates up to ~16K/year.  Applicants must be nominated by a mentor who is an independently funded investigator.  One or more COMET program core faculty members must be involved in the trainee’s work.

We are accepting applications for slots beginning in July 2020. Please see the URL below for more information about the program and for application materials.  

http://oracore.bwh.harvard.edu/careers-training/training-opportunities/comet-position/

Postdoctoral position in the laboratory of Deborah Veis, MD, PhD in the Department of Internal Medicine – Division of Bone and Mineral Diseases, Washington University School of Medicine in St. Louis, MO. The research interest of this lab is to elucidate the cellular and molecular mechanisms underlying pathological bone loss.  Major ongoing projects include the study of mitochondrial dynamics in bone cells (osteoblasts and osteoclasts), and mechanisms of host-pathogen interactions in osteomyelitis.  The approaches include the use of genetically engineered mice and pathogenic bacterial strains, histological and structural analyses (such as with microCT), confocal microscopy, mechanical testing, and culture of primary murine and human cells.

The applicant must have a PhD degree and should be highly motivated, eager and quick to learn, careful, organized, and reliable. The candidate must be able to work independently and communicate with laboratory staff and collaborating investigators. Strong written and oral communication skills are essential.  Expertise in cell culture and molecular biology, mouse genotyping, plasmid and retrovirus preparation and gene transfer, and protein analysis (Western blot, FACS, IHC/IF and ELISA) is helpful. Previous microbiology experience, especially with bacterial culture and genetic manipulation would be a plus, as would experience with whole animal imaging approaches such as bioluminescence imaging or microCT, Experience with histology, including immunostaining and confocal microscopy, and/or with analysis of mitochondria/cell metabolism would be welcome.

To apply for this position, please send a cover letter and C.V. to:

Deborah Veis, MD, PhD

dveis@wustl.edu

http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=5864

POSITION

Postdoctoral position available to study articular cartilage transcriptional regulatory network.

GENERAL SUMMARY/OVERVIEW STATEMENT

Postdoctoral position is available in the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dr. Andrew Lassar, PhD Laboratory. The Postdoc will study the transcriptional regulatory network that controls both the formation and maintenance of articular cartilage. Current efforts are to understand how extracellular signals either promote the expression and/or regulate the activity of a newly identified articular cartilage transcription factor that is essential for articular cartilage formation.

EDUCATION AND EXPERIENCE REQUIRED

• Student and/or present postdoctoral fellow who has an excellent working knowledge of molecular biology techniques.
• Specifically looking for someone who wants to ask basic questions about synovial joint formation and apply this knowledge to develop regenerative approaches to treat joint pathology.  
• The ability to work constructively with others, with honesty and enthusiasm are all a must for this position.
• Prior work with genetically engineered mice and/or regulation of gene expression would be a plus.

TO APPLY

Please contact: Dr. Andrew Lassar Ph.D.

Professor
Department of Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Bldg C-Room 305A
240 Longwood Ave.
Boston, MA. 02115

tel. 617-432-3831
fax. 617-738-0516
e. mail: andrew_lassar@hms.harvard.edu

Karen M. Lyons, Ph.D.
Professor
Department of Orhopaedic Surgery and Molecular, Cell and Developmental Biology
University of California, Los Angeles

“Pathfinding, Careers, and Lessons Learned”
Please click here to view the slides

Those who attended Dr. Karen Lyons’ talk on the day of the Center for Skeletal Research Symposium on May 13, 2019, suggested that we post her slides. We’ve done that in “News”.