A full-time Research /Technician Technologist position is available in the Endocrine Unit at Massachusetts General Hospital. Position will be commensurate with experience.
Please apply on the MGH Careers website
Job Number 3124551
A Research Technician position is available in Dr. Murat Bastepe’s Laboratory. The Research Laboratory Technician I is a full-time position, and the primary responsibility is to assist in ongoing research studies under the supervision of a Principal Investigator in the Endocrine Unit at Massachusetts General Hospital. The MGH Endocrine Unit is a leader in investigating, diagnosing and treating disorders of bone and mineral metabolism, thyroid diseases and general endocrine conditions.
Please apply on the MGH Careers website
Job Number 3124133
Postdoctoral Position: Click here to download description
POSITION
Postdoctoral position available to study epigenetic control of skeletal development
GENERAL SUMMARY/OVERVIEW STATEMENT
Postdoctoral position is available in the laboratory of Dr. Diana Carlone, Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School. My laboratory is investigating the role of epigenetics in limb mesenchymal progenitor cell differentiation during endochondral ossification. We have identified a factor that is crucial for the initial stages of chondrogenesis and also for growth plate development. The focus of this position is to determine the interplay between this newly identified factor and the gene regulatory network and molecular mechanisms that control skeletal development. This project was recently funded by NIAMS.
EDUCATION AND EXPERIENCE REQUIRED
The applicant must have a PhD, MD or MD/PhD degree. We seek a highly motivated, organized and reliable person who can work independently with strong written and oral communication skills. This project involves the use of genetically engineered mice, histological analyses and culture of primary cells and cell lines. Prior experience in limb and skeletal development and/or large scale data analysis, specifically ChIP-seq and RNA-seq, is a plus.
APPLICATION REQUIREMENTS
To apply for this position, please email a cover letter and C.V. to:
Dr. Diana Carlone, Ph.D.
Diana.carlone@childrens.harvard.edu
The Fibrous Dysplasia Foundation has released an announcement regarding the US Department of Defense’s new funding mechanism for research studies relating to Fibrous Dysplasia.
For more information, follow this link: https://myemail.constantcontact.com/Important-Funding-Announcement-for-Fibrous-Dysplasia-Research.html?soid=1122055619308&aid=G9bqc4zNiy4
Postdoctoral Fellow (Bastepe Lab) Click here to download description
GENERAL SUMMARY/ OVERVIEW STATEMENT:
A Postdoctoral Fellow position is available in the laboratory of Dr. Murat Bastepe in the Endocrine Unit at the Massachusetts General Hospital (MGH). MGH is a Harvard Medical School (HMS)-affiliated hospital. This is a full-time position with an affiliated Research Fellow appointment proposed at Harvard Medical School (HMS). This position is contingent upon successful credentialing by the MGH Registrar/Credentialing Unit.
PRINCIPAL DUTIES AND RESPONSIBILITIES:
Conduct cell-based in vitro experiments, combined with in vivo analyses of several different mouse models to study the role of Gq/11-PKC signaling in the synthesis of FGF23 in bone. The main focus will be the mechanisms governing FGF23 production in response to lysophosphatidic acid and in the setting of different renal failure models. Studies will also address the role of this signaling pathway in phosphate- and 1,25-dihydroxyvitamin D-induced FGF23 synthesis. The project will lead to improved understanding of basic biological mechanisms important for mineral ion homeostasis.
EDUCATION AND EXPERIENCE REQUIRED:
WORKING CONDITIONS:
We strive for impactful science in a collegial and highly-collaborative environment. Career development is a major priority. Post-doctoral fellows will benefit from connections to premier academic laboratories, hospitals, and research institutions in the greater Boston biomedical environment. MGH and HMS are affirmative action/equal opportunity employers.
APPLICATION REQUIREMENTS:
Interested candidates should send a cover letter, CV and contact information for at least three references to:
Murat Bastepe, MD, PhD
MGH, Endocrine Unit
Thier Building, Room 1035
50 Blossom Street
Boston, MA 02114 USA
bastepe@helix.mgh.harvard.edu
The Clinical Orthopedic and Musculoskeletal Education and Training Program (COMET) is an NIH-funded T32 training program based at Brigham and Women’s Hospital and Harvard Medical School. COMET is intended to train highly qualified pre- and post-doctoral trainees in rigorous clinical research methods to address pressing problems relating to orthopedic and musculoskeletal disorders. The range of methodologies suitable for support is wide, including epidemiology, biostatistics, economics, pharmaco-epidemiology, policy modeling, decision making and decision analysis among others. The range of substantive topics is similarly wide, encompassing orthopedic surgical interventions and disorders affecting the musculoskeletal system including, but not limited to, osteoarthritis, osteoporosis, spinal disorders, regional musculoskeletal disorders, tendon, ligament and other soft tissue conditions, and musculoskeletal pain. The research must be carried out on humans. Research focused on inflammatory disorders (such as rheumatoid arthritis) are appropriate if the research specifically involves orthopedic interventions or musculoskeletal manifestations such as osteoporosis and fracture.
Per NIH guidelines, applicants must be citizens of the United States or have been lawfully admitted for permanent residence at the time of appointment. Underrepresented minority groups including are strongly encouraged to apply.
Trainees accepted for the program will be funded, in general, for two years, conditional on a progress report at the end of the first year. The training grant covers salary or stipend, travel to professional meetings, and other training-related expenses. The postdoctoral award will cover 60% of tuition for the Program in Clinical Effectiveness at Harvard School of Public Health (up to ~16K/year). The predoctoral award includes a stipend for 60% of tuition for PhD candidates up to ~16K/year. Applicants must be nominated by a mentor who is an independently funded investigator. One or more COMET program core faculty members must be involved in the trainee’s work.
We are accepting applications for slots beginning in July 2020. Please see the URL below for more information about the program and for application materials.
http://oracore.bwh.harvard.edu/careers-training/training-opportunities/comet-position/
The Departments of Orthopaedics and Sports Medicine (School of Medicine) and Mechanical Engineering (College of Engineering), in partnership with the Institute for Stem Cell and Regenerative Medicine (ISCRM), invite applications for a full-time associate professor with tenure or professor with tenure commensurate with experience. This position is supported in part by the Endowed Chair for Women’s Sports and Lifetime Fitness.
For more information and to apply, please visit: http://apply.interfolio.com/68298
Postdoctoral position in the laboratory of Deborah Veis, MD, PhD in the Department of Internal Medicine – Division of Bone and Mineral Diseases, Washington University School of Medicine in St. Louis, MO. The research interest of this lab is to elucidate the cellular and molecular mechanisms underlying pathological bone loss. Major ongoing projects include the study of mitochondrial dynamics in bone cells (osteoblasts and osteoclasts), and mechanisms of host-pathogen interactions in osteomyelitis. The approaches include the use of genetically engineered mice and pathogenic bacterial strains, histological and structural analyses (such as with microCT), confocal microscopy, mechanical testing, and culture of primary murine and human cells.
The applicant must have a PhD degree and should be highly motivated, eager and quick to learn, careful, organized, and reliable. The candidate must be able to work independently and communicate with laboratory staff and collaborating investigators. Strong written and oral communication skills are essential. Expertise in cell culture and molecular biology, mouse genotyping, plasmid and retrovirus preparation and gene transfer, and protein analysis (Western blot, FACS, IHC/IF and ELISA) is helpful. Previous microbiology experience, especially with bacterial culture and genetic manipulation would be a plus, as would experience with whole animal imaging approaches such as bioluminescence imaging or microCT, Experience with histology, including immunostaining and confocal microscopy, and/or with analysis of mitochondria/cell metabolism would be welcome.
To apply for this position, please send a cover letter and C.V. to:
Deborah Veis, MD, PhD
http://dbbs.wustl.edu/faculty/Pages/faculty_bio.aspx?SID=5864
Research Scientist – Search Number 2017-1229
We are writing to ask for your assistance in identifying a Research Scientist to join the Department of Orthopaedic Surgery within the UConn Musculoskeletal Institute at the Assistant or Associate Professor level in the tenure track. We are searching for an outstanding individual working in skeletal cell biology and wanting to make a difference in the field of musculoskeletal research. A Ph.D. or an M.D. degree is required.
Candidates’ research should be aimed at addressing fundamental questions related to cellular, molecular or physiological mechanisms of the skeletal system. We are particularly interested in individuals currently funded by the National Institutes of Health.
The University of Connecticut School of Medicine has a highly interactive research environment with interdisciplinary graduate and medical science training programs. The Musculoskeletal Institute offers a collegial environment and houses investigators working on various aspects of skeletal cell biology and biomechanics of bone. There is ample opportunity to interact/work with basic and physician scientists, including orthopaedic surgeons, a spine clinician scientist and osteoporosis specialists. Appropriate laboratory space and a start-up package will be offered.
Candidates for the Research Scientist position can apply to Job Search 2017-1229 or contact canalis@uchc.edu and imoss@uchc.edu.
Thank you for your assistance on this important search.
Sincerely,
|
Isaac L. Moss, MD, MASc, FRCSC Associate Professor, Orthopaedic Surgery Interim Chair, Department of Orthopaedic Surgery |
|
Ernesto Canalis, MD Professor, Orthopaedic Surgery and Medicine Director, Center for Skeletal Research |
Ernesto Canalis | Professor, Orthopaedic Surgery and Medicine
Director, Center for Skeletal Research
Department of Orthopaedic Surgery | UConn Health
263 Farmington Avenue, Farmington, CT 06030-4037
Office: 860.679.7978 ; 860.679.6622 | Fax: 860.679.1474
POSITION
Postdoctoral position available to study articular cartilage transcriptional regulatory network.
GENERAL SUMMARY/OVERVIEW STATEMENT
Postdoctoral position is available in the Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Dr. Andrew Lassar, PhD Laboratory. The Postdoc will study the transcriptional regulatory network that controls both the formation and maintenance of articular cartilage. Current efforts are to understand how extracellular signals either promote the expression and/or regulate the activity of a newly identified articular cartilage transcription factor that is essential for articular cartilage formation.
EDUCATION AND EXPERIENCE REQUIRED
TO APPLY
Please contact: Dr. Andrew Lassar Ph.D.
Professor
Department of Biological Chemistry and Molecular Pharmacology
Harvard Medical School
Bldg C-Room 305A
240 Longwood Ave.
Boston, MA. 02115
tel. 617-432-3831
fax. 617-738-0516
e. mail: andrew_lassar@hms.harvard.edu
Center for Skeletal Research
Endocrine Unit
Massachusetts General Hospital
50 Blossom Street, Thier 1101
Boston, MA 02114-2696
Telephone: 617-726-3967
Fax: 617-726-7543
Email: csrmail@partners.org
