Archive for category: News

Research Technician Position at MGH Endocrine Unit, Marc Wein Laboratory

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A Research Technician position is open in Dr. Marc Wein’s laboratory in the MGH Endocrine Unit. Responsibilities include collection of and accurate recording of procedures and results, maintenance of databases used in the lab, ordering necessary reagents to conduct experiments, and participation in joint upkeep of the lab. This position requires a person who has Bachelor of Science degree in molecular/cell biology, biochemistry or a related field, pays attention to details, is capable of working independently under close supervision after initial training, possesses good verbal and written communication skills, and works well as part of a team. Work is reviewed regularly with the Principal Investigator who is available to troubleshoot problems.

Please visit the MGH Careers website (Job ID 3142544) to view job description and submit an application.

 

 

Postdoctoral Fellow Position – Evolutionary and Developmental Genetics Laboratory, Dr. Terence D. Capellini

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The Department of Human Evolutionary Biology at Harvard University invites applications for a Postdoctoral Fellow in the Evolutionary and Developmental Genetics Laboratory of Dr. Terence D. Capellini.  The focus of the position will be to study the genetic and developmental basis of human-specific adaptations and disease.  While the lab primarily concentrates on skeletal adaptations in humans and primates, an important research focus is to identify causal genetic variants that mediate human phenotypes resulting from more recent selection. The lab uses a variety of experimental and computational tools, such as functional genomics (e.g., ATAC-seq), developmental genetics in the mouse (e.g., CRISPR-Cas9), and in vitro methods on human cells, to explore the consequences of genetics variants on human biology. 

The research will take place in the Evolutionary and Developmental Genetics Laboratory directed by Dr. Capellini and located in the Peabody Museum on Harvard University’s Cambridge, Massachusetts campus. A doctoral degree is required for this position. Desired qualifications include research in developmental genetics, functional genomics, evolutionary developmental biology, mouse developmental biology and/or human evolutionary genetics.  

Please submit a letter of interest, an updated CV, and the names and email addresses of three references to Terence Capellini at tcapellini@fas.harvard.edu.  Evaluation will begin at the time this advertisement is posted and will continue until the position is filled.

The lab’s website is: http://projects.iq.harvard.edu/evolutionary_genetics/home

 

Harvard University is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, sexual identity, national origin, disability status, protected veteran status, or any other characteristic protected by law.

 

RESEARCH TECHNICIAN, BONE CELL CORE, Goldman School of Dental Medicine

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Job Description

The Bone Cell Core in the Department of Translational Dental Medicine, at H.Goldman School of Dental Medicine, Boston University has an opening for a part-time (20hrs/week) position for a Research technician. Bone Cells Core Technician will have the task of performing Core related tasks and completing services provided by the Bone Cell Core in accordance with Boston University Policies.

Required Skills

Previous laboratory experience in cell culture is required. The Technician will work with both human and animals samples. High level of organization and time-management required. Bachelor’s degree required.

We are an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability status, protected veteran status, or any other characteristic protected by law. We are a VEVRAA Federal Contractor.

Job Location:  BOSTON, Massachusetts, United States

Position Type:  Part-Time

Please click here for more information

 

CMTM Postdoctoral Research Fellow Position

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The Center for Multiscale & Translational Mechanobiology currently has one full-time Postdoctoral Research Fellow position open with a start date of summer 2021.  Postdoctoral fellow positions are open to individuals who have received a doctoral degree or equivalent.  Candidates are expected to have a proven publication record and the ability to work both independently and as part of a team.

Click here for more information.

Multiple PhD and Postdoctoral Associate Positions Open!

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Click here to download description

The Bajpayee lab at Northeastern University in Boston is looking for candidates with interest and expertise in chemical conjugation, peptide design and synthesis, particle formulation, drug delivery and animal studies. We are looking for highly motivated and independent researchers to carry out work in design of electrically charged protein, peptide and exosome based nanocarriers, drug conjugation, modeling transport properties in tissue culture models, examining the pharmacokinetics, biodistribution and tissue targeting efficacy of drugs in injury induced animal models of osteoarthritis. Experience in the following technical areas is preferred: rodent traumatic models of osteoarthritis, small animal surgery and in vivo imaging, molecular and cell biology, flow cytometry and FACS,and immunohistochemistry and imaging.

For post-doc position, prior experience in orthopedic labs and in-vivo models is desired. Individuals must have a Ph.D. and/or M.D., appropriate research experience, strong organizational, interpersonal, communication, and computer skills and be prepared to work in a dynamic multi-disciplinary team environment. Applicants with a strong training background and publication track record in material synthesizes, drug delivery or cartilage biology are highly encouraged to apply.

This is an ideal position for someone looking for experience in translational research to train for both academia and industry. Please email your CV with names of three references to a.bajpayee@neu.edu

About Bajpayee lab: (more at https://web.northeastern.edu/bajpayeelab/)
Bajpayee lab works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes. Their dense extracellular matrix, however, hinders penetration of most drugs. We utilize concepts of nanomedicine and bio-electrostatics to design polypeptides, protein and cell derived exosomebased carriers for targeted and sustained delivery of small molecule drugs, protein growth factors, antibodies and genetic materials to specific intra-tissue and intra-cellular target sites inside connective tissues. A main focus is on using charge interactions and other binding mechanisms to rationally design drug carriers that can penetrate through the dense matrix of avascular, negatively charged tissues. We are also interested in understanding mechanisms leading to degenerative joint diseases (e.g., osteoarthritis) due to ageing and traumatic injuries. The lab strives to combine basic science with translational research to develop biomedical technologies. Our Lab is highly interdisciplinary and collaborative with established collaborations with Harvard Medical School, MIT,BUMC and MGH.

 

Two postdoctoral positions at Harvard Medical School/Harvard School of Dental Medicine in Drs. Baron and Gori joint Laboratory

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POSITIONS

Two postdoctoral positions at Harvard Medical School/Harvard School of Dental Medicine in Drs. Baron and Gori joint Laboratory (Baron-Gori lab).

GENERAL SUMMARY

Two Postdoctoral positions are available in the joint laboratory of Dr. Baron and Dr. Gori, Division of Bone and Mineral Research, Department of Medicine, Harvard Medical School/ Harvard School of Dental Medicine.

The longstanding interest of our laboratory is to understand the molecular, cellular and genetic basis of bone growth and remodeling and the regulation of skeletal homeostasis in health and disease in humans, using animal models.

The focus of one of these positions is to study the biology of the periosteal surface. In particular, our objective is to identify the role of Sfrp4, a Wnt signaling inhibitor we have shown to be implicated in Pyle disease, in the expansion, differentiation and/or function of periosteal stem and osteoprogenitor cells.

The focus of the other position is to examine novel signaling mechanisms by which PTH regulates Wnt signaling, increases bone formation rate and represses bone marrow adipose tissue and its role in the anabolic action of PTH/PTHrP in bone. A separate aspect of this work is to understand the role of osteocyte biology in the responses to PTH/PTHrP.

Our laboratory aims for excellence in research and makes all efforts to publishing its work in the top tier scientific and medical journals. Training of young scientists is also a key aspect of our laboratory, with a very successful history.

The Baron/Gori laboratory is currently funded by three NIH institutes: NIDCR (Gori), NIDDK and NIAMS (Baron) as well as by other sources.

EDUCATION AND EXPERIENCE REQUIRED

The applicants must have a PhD degree. Combined MD/PhD or DDS-DMD/PhD degrees are a plus. We seek highly motivated young scientists who can work independently with strong written and oral communication skills. These projects involve the use of genetically engineered mice, cell and molecular biology and bioinformatic techniques as well as culture of primary cells and cell lines. Commensurate with experience, first author publication(s) in top-tier bone and/or cell and molecular biology journals, expertise in signal transduction analysis, FACS analysis and/or large-scale data analysis, specifically bulk and single cell RNA-seq, will be considered a plus. Prior experience in skeletal research in addition to the above skills is a plus but not a requirement.

APPLICATION REQUIREMENTS

To apply for this position, please email a cover letter, C.V. and three reference contacts to:

Francesca_gori@hsdm.harvard.edu and Roland_Baron@hms.harvard.edu

 

 

 

Postdoctoral Position at Boston Children’s Hospital, Dr. Diana Carlone, PhD Laboratory

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Postdoctoral Position: Click here to download description

POSITION

Postdoctoral position available to study epigenetic control of skeletal development

GENERAL SUMMARY/OVERVIEW STATEMENT

Postdoctoral position is available in the laboratory of Dr. Diana Carlone, Division of Endocrinology, Boston Children’s Hospital, Harvard Medical School. My laboratory is investigating the role of epigenetics in limb mesenchymal progenitor cell differentiation during endochondral ossification. We have identified a factor that is crucial for the initial stages of chondrogenesis and also for growth plate development. The focus of this position is to determine the interplay between this newly identified factor and the gene regulatory network and molecular mechanisms that control skeletal development. This project was recently funded by NIAMS.

EDUCATION AND EXPERIENCE REQUIRED

The applicant must have a PhD, MD or MD/PhD degree. We seek a highly motivated, organized and reliable person who can work independently with strong written and oral communication skills. This project involves the use of genetically engineered mice, histological analyses and culture of primary cells and cell lines. Prior experience in limb and skeletal development and/or large scale data analysis, specifically ChIP-seq and RNA-seq, is a plus.

APPLICATION REQUIREMENTS

To apply for this position, please email a cover letter and C.V. to:

Dr. Diana Carlone, Ph.D.

Diana.carlone@childrens.harvard.edu

 

Fibrous Dysplasia Foundation Announcement: New Grants from Defense Department for Fibrous Dysplasia

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The Fibrous Dysplasia Foundation has released an announcement regarding the US Department of Defense’s new funding mechanism for research studies relating to Fibrous Dysplasia.

For more information, follow this link: https://myemail.constantcontact.com/Important-Funding-Announcement-for-Fibrous-Dysplasia-Research.html?soid=1122055619308&aid=G9bqc4zNiy4

 

 

T32 pre and postdoctoral slots available for clinical/translational MSK research

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The Clinical Orthopedic and Musculoskeletal Education and Training Program (COMET) is an NIH-funded T32 training program based at Brigham and Women’s Hospital and Harvard Medical School. COMET is intended to train highly qualified pre- and post-doctoral trainees in rigorous clinical research methods to address pressing problems relating to orthopedic and musculoskeletal disorders.  The range of methodologies suitable for support is wide, including epidemiology, biostatistics, economics, pharmaco-epidemiology, policy modeling, decision making and decision analysis among others.  The range of substantive topics is similarly wide, encompassing orthopedic surgical interventions and disorders affecting the musculoskeletal system including, but not limited to, osteoarthritis, osteoporosis, spinal disorders, regional musculoskeletal disorders, tendon, ligament and other soft tissue conditions, and musculoskeletal pain.  The research must be carried out on humans.  Research focused on inflammatory disorders (such as rheumatoid arthritis) are appropriate if the research specifically involves orthopedic interventions or musculoskeletal manifestations such as osteoporosis and fracture.

Per NIH guidelines, applicants must be citizens of the United States or have been lawfully admitted for permanent residence at the time of appointment.  Underrepresented minority groups including are strongly encouraged to apply.

Trainees accepted for the program will be funded, in general, for two years, conditional on a progress report at the end of the first year.  The training grant covers salary or stipend, travel to professional meetings, and other training-related expenses.  The postdoctoral award will cover 60% of tuition for the Program in Clinical Effectiveness at Harvard School of Public Health (up to ~16K/year).  The predoctoral award includes a stipend for 60% of tuition for PhD candidates up to ~16K/year.  Applicants must be nominated by a mentor who is an independently funded investigator.  One or more COMET program core faculty members must be involved in the trainee’s work.

We are accepting applications for slots beginning in July 2020. Please see the URL below for more information about the program and for application materials.  

http://oracore.bwh.harvard.edu/careers-training/training-opportunities/comet-position/