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GENERAL SUMMARY:

The Research Technician is a full-time position, and the primary responsibility is to participate and assist in ongoing research studies under the supervision of a Principal Investigator in the Endocrine Unit at Massachusetts General Hospital. The MGH Endocrine Unit is a leader in investigating, diagnosing and treating disorders of bone and mineral metabolism, thyroid diseases and general endocrine conditions. The Peptide/Protein Core Facility provides the services of peptide synthesis, purification and analysis. Position will be commensurate with experience.

PRINCIPAL DUTIES AND RESPONSIBILITIES:

Responsibilities comprise, but are not limited to:

• Synthesis, purification and analysis of peptides using automated instruments.
• Operates moderately complex equipment including peptide synthesizers, centrifuges, spectrophotometers, HPLCs and mass spectrometers.
• Responsible for ordering common laboratory reagents and other supplies and for assuring that supply levels in the lab are adequate.  Prepares materials for shipping.

• Techniques used will include: Synthesis of peptides using solid-phase Fmoc chemistry approaches (manual and automatic), purification using preparative HPLCs and analysis using analytical HPLCs and mass spectrometry.
• Organizes and accurately maintains written records of experimental procedures and data collection.
• Participates in upkeep of lab, performs basic maintenance on laboratory equipment (cleans, disassembles, stores, replaces worn parts) and reports equipment requiring advanced repair.
• Participates in and presents data at lab meetings.
• Interacts well with others, assists in training laboratory personnel in lab techniques and procedures that have been acquired.

 QUALIFICATIONS:

• BS, MS or Ph.D. in biology, molecular biology, biochemistry or Chemistry.
• Must be self-motivated and able to work independently.
• Excellent verbal and written communication skills

SKILLS/ABILITIES/COMPETENCIES REQUIRED:

Experience with Synthesis, purification and analysis of peptides using automated instruments is preferred. Ability to build upon basic techniques, learning or helping to develop new ones as necessary, to conduct the research project.

Basic proficiency in Word, Power point, Excel, and Internet searches is required.

WORKING CONDITIONS:

• Duties will be performed in a research laboratory. Must be willing to work with chemicals.
• Work will be conducted over a 40-hour workweek.

APPLICATION:

Apply on the MGH Careers Website: https://www.massgeneral.org/careers/apply  

Job ID# 3183973

The Program Directors of the Center for Skeletal Research would like your help in thinking about new directions, new areas of emphasis that the Center can consider moving into.  Our Center is now about eight years old.  While we have introduced a number of new initiatives in the last few years, there is always the danger that we might not be looking at current bone biology with the freshest perspectives.  When the Center goes to NIH hoping to renew the grant (or in NIH terminology, apply again for a new grant), we are likely to have some changes in leadership and emphasis, and we want to make changes in the most thoughtful way possible.  For this reason we would like to establish a New Directions Committee, with the mission of surveying the field and the capabilities in the Boston area to then come up with suggestions for modifying current cores or establishing completely new cores with new goals.  If you would be interested in joining this effort, please let us know by e-mailing CSRmail@partners.org, and we’ll organize next steps.

A Postdoctoral Fellow position is available in the laboratory of Dr. Michael Mannstadt in the Endocrine Unit at the Massachusetts General Hospital (MGH). MGH is a Harvard Medical School (HMS)-affiliated hospital. This is a full-time position with an affiliated Research Fellow appointment proposed at Harvard Medical School (HMS). Employment is contingent upon successful completion of professional credentialing by the MGH Registrar/Credentialing Unit and final appointment by the Trustees of the Hospital to the Staff.

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