CSR Wednesday Research Seminar

The Center for Musculoskeletal Research (CSR), based in the Endocrine Unit at MGH, and funded by the National Institute of Arthritis and Musculoskeletal Diseases (NIAMS) is announcing a request for Pilot and Feasibility Research proposals ($35,000/year), NO RENEWALS ARE ALLOWED. The Awardees will be expected to present progress to CSR members biannually and provide a written annual report.

LETTER OF INTENT DUE MONDAY AUGUST 19, 2024, 5PM EST

Letter of intent should include

a 250 word abstract

a 150 word statement of eligibility

an NIH style biosketch including all other support

Please submit in a single PDF file to csrmail@partners.org

In the subject line include your last name and “P30P+F LOI” eg: SmithP30P+F LOI

DETAILS BELOW

THOSE INVITED TO APPLY FOR FUNDING WILL BE INFORMED BY

Monday August 26, 2024

A THREE PAGE SCIENTIFIC PROPOSAL WILL BE REQUIRED BY

Monday September 30, 2024

Expected funding date (depending on NIH approval) Monday, December 2, 2024

Eligibility is based on the criteria listed below:

Junior faculty proposing highly focused Musculoskeletal Biology (including muscle) research projects with the goal of generating preliminary data sufficient to support an application for independent NIH research support. Applicants in this group must meet the NIH Early Investigator Criteria(New Investigators who have had less than 10 years of research or research training experience after the completion of their terminal research degree or medical residency, see http://grants.nih.gov/grants/new_investigators/index.htm) Awardees of K grants may apply with committed effort but cannot receive salary from the P&F.
Established researchers from outside the bone field proposing innovative studies relevant to Musculoskeletal Biology.
Established Musculoskeletal Biology investigators proposing studies relevant to Musculoskeletal Biology that represents a clear departure from their established line of investigation.

Investigators must invest at least 1 calendar month of effort. If salary requests do not reflect this effort, cost-sharing plans must be indicated. Applicants who are not U.S. citizens or permanent U.S. residents must have active visas permitting them to remain in the U.S. for the full period of the proposed research.

CSR Light-seq Spatial Transcriptomics RFA – deadline 9/15/24

July 2024/in Uncategorized/by Melissa Machado

CENTER FOR MUSCULOSKELETAL RESEARCH

RFA for Light-seq Spatial Transcriptomics

The RNA sequencing and spatial transcriptomics core has a request for application (RFA) for Light-Seq spatial transcriptomics projects from CSR members Light-seq captures up to 4 different cell types of interest or 4 different regions of interest in tissue sections.

Technical support and supply costs will be provided for murine projects that involve non-mineralized musculoskeletal tissues (e.g., tendon, ligament, cartilage, synovium, muscle, embryonic musculoskeletal elements); the core is still developing Light-Seq for mineralized tissues.

Questions about Light-Seq in general, and this RFA specifically, can be sent to Dr. Matthew Warman (matthew.warman@childrens.harvard.edu).

CSR Investigators interested in applying to this RFA should email to MGH-CSR (add email address) a short paragraph discussing the tissue they would like to analyze and the biological question that they would like to address. Please use “Light-Seq application” in the email Subject line

Selected projects will be asked to provide 1 page application describing the project, the biologic question Light-Seq could answer, the cell type(s) or region(s) of interest to be sequenced, the number of available biologic replicates, and a time frame of when specimens will be available for analyses. They will also be asked to present their results to the CSR community.

Deadline for application: September 15^th 2024

To learn more about Light-seq click here

https://wyss.harvard.edu/media-post/light-seq-light-directed-in-situ-barcoding-of-biomolecules/

CSR Outstanding Manuscript Award 2025

June 2024/in Uncategorized/by Melissa Machado

CSR Outstanding Manuscript Award 2025

Recordings of presentations from over 1 year ago

June 2024/in Uncategorized/by Melissa Machado

CSR Journal Club Recordings

“Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice” by Tadatoshi Sato, PhD (Click here for the article), March 22, 2023

“Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3 , the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood” by April Craft, MD (Click here for the article), September 13, 2023

CSR Friday Research Seminar Series 2022-2023

October 7, 2022 including:

“Genetics of Osteoblast Function in Osteogenesis Imperfecta” by Christina Jacobsen, M.D., Ph.D., BCH
“Roles of Gnaq and Gna11 in the synthesis of the phosphaturic hormone, Fibroblast Growth Factor 23 (FGF23)” by Birol Ay, MSc, Ph.D., MGH

November 7, 2022 with UCSF including:

“The role of BMP2 in periosteal appositional growth” by Emily Moore, HSDM
“Patient Phenotyping, Levels of Evidence, and Machine Learning for Clinical Research” by Thomas Peterson, PhD, UCSF

December 2, 2022 with UCSF including:

“Implications of Aging on Studying and Treating Multi-Tissue Joint Injury” by Brianne Connizzo, Ph.D., BU
“Bugs, Drugs, and Autoimmunity: The Impact of the Gut Microbiome on the Treatment of Rheumatic Disease” by Renuka Nayak, MD, PhD, UCSF

January 6, 2023 including:

“A Conserved Transcription Factor Regulatory Program Promotes Tendon Fate” by Xubo Niu, PhD, HMS
“Novel iPSC-based model of Progressive Pseudorheumatoid Arthropathy of Childhood points to abnormal TGFb signaling in premature cartilage failure” by Chaochang Li, PhD, Harvard Stem Cell Institute

March 3, 2023 with UCSF including:

“Salt-Inducible Kinases (SIKs) control PTH-induced Cyp27b1 expression in kidney” by Seanna Yoon, PhD, MGH
“Body Compositional Changes in Long Term HIV Infection under Effective Antiretroviral Treatment: Decoupling of Spinal and Femoral Bone Marrow Adiposity in People Living with HIV.” by Zehra Akkaya, UCSF

April 14, 2023 including:

“Regulation of Gdf5 and its impact on joint morphology and cartilage health” by Clarissa Coveney, DPhil, Harvard University
“New insights into GNAS imprinting and autosomal dominant pseudohypoparathyroidism” by Yorihiro Iwasaki, MD, PhD, MGH

May 5, 2023 with UCSF including:

“The Role of Piezo1 in Osteocyte Maturation” by Jenny Yizhong Hu, PhD, HSDM
“Multi-omics Approaches to Uncover Mediators of Fat-Cartilage Crosstalk in Osteoarthritis” by Kelsey Collins, PhD, UCSF

June 2, 2023 including:

“Delayed ossification and pseudohypoparathyroidism associated with PTH1R mutations” by Ignacio Portales-Castillo, MD, Washington University in St. Louis
“Src-dependent phosphorylation of YAP-Y 428 by PTH is required for osteoblast differentiation of bone marrow stromal cells” by Sara Monaci, PhD, HSDM

CSR Methods Workshops

“Introduction to the CSR RNA-Seq Core” by Catherine May (BCH)

“Evaluation of Muscle Function: The Benefits” by LaDora Thompson, PhD, PT (BUSM)

“Clinical Phenotyping of Preclinical Data to Study Disease Mechanism and Biomarker Discovery” by Terence Capellini, PhD (Harvard University) and Ata Kiapour, PhD, MMSc (BCH)