CSR Journal Club Recordings

“Structure-based design of selective, orally available salt-inducible kinase inhibitors that stimulate bone formation in mice” by Tadatoshi Sato, PhD (Click here for the article), March 22, 2023

“Directed differentiation of human pluripotent stem cells into articular cartilage reveals effects caused by absence of WISP3 , the gene responsible for Progressive Pseudorheumatoid Arthropathy of Childhood” by April Craft, MD (Click here for the article), September 13, 2023

CSR Friday Research Seminar Series 2022-2023

October 7, 2022 including:

“Genetics of Osteoblast Function in Osteogenesis Imperfecta” by Christina Jacobsen, M.D., Ph.D., BCH
“Roles of Gnaq and Gna11 in the synthesis of the phosphaturic hormone, Fibroblast Growth Factor 23 (FGF23)” by Birol Ay, MSc, Ph.D., MGH

November 7, 2022 with UCSF including:

“The role of BMP2 in periosteal appositional growth” by Emily Moore, HSDM
“Patient Phenotyping, Levels of Evidence, and Machine Learning for Clinical Research” by Thomas Peterson, PhD, UCSF

December 2, 2022 with UCSF including:

“Implications of Aging on Studying and Treating Multi-Tissue Joint Injury” by Brianne Connizzo, Ph.D., BU
“Bugs, Drugs, and Autoimmunity: The Impact of the Gut Microbiome on the Treatment of Rheumatic Disease” by Renuka Nayak, MD, PhD, UCSF

January 6, 2023 including:

“A Conserved Transcription Factor Regulatory Program Promotes Tendon Fate” by Xubo Niu, PhD, HMS
“Novel iPSC-based model of Progressive Pseudorheumatoid Arthropathy of Childhood points to abnormal TGFb signaling in premature cartilage failure” by Chaochang Li, PhD, Harvard Stem Cell Institute

March 3, 2023 with UCSF including:

“Salt-Inducible Kinases (SIKs) control PTH-induced Cyp27b1 expression in kidney” by Seanna Yoon, PhD, MGH
“Body Compositional Changes in Long Term HIV Infection under Effective Antiretroviral Treatment: Decoupling of Spinal and Femoral Bone Marrow Adiposity in People Living with HIV.” by Zehra Akkaya, UCSF

April 14, 2023 including:

“Regulation of Gdf5 and its impact on joint morphology and cartilage health” by Clarissa Coveney, DPhil, Harvard University
“New insights into GNAS imprinting and autosomal dominant pseudohypoparathyroidism” by Yorihiro Iwasaki, MD, PhD, MGH

May 5, 2023 with UCSF including:

“The Role of Piezo1 in Osteocyte Maturation” by Jenny Yizhong Hu, PhD, HSDM
“Multi-omics Approaches to Uncover Mediators of Fat-Cartilage Crosstalk in Osteoarthritis” by Kelsey Collins, PhD, UCSF

June 2, 2023 including:

“Delayed ossification and pseudohypoparathyroidism associated with PTH1R mutations” by Ignacio Portales-Castillo, MD, Washington University in St. Louis
“Src-dependent phosphorylation of YAP-Y 428 by PTH is required for osteoblast differentiation of bone marrow stromal cells” by Sara Monaci, PhD, HSDM

CSR Methods Workshops

“Introduction to the CSR RNA-Seq Core” by Catherine May (BCH)

“Evaluation of Muscle Function: The Benefits” by LaDora Thompson, PhD, PT (BUSM)

“Clinical Phenotyping of Preclinical Data to Study Disease Mechanism and Biomarker Discovery” by Terence Capellini, PhD (Harvard University) and Ata Kiapour, PhD, MMSc (BCH)