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2023 P30 Pilot & Feasibility Award RFA

2023 P30 Pilot & Feasibility Award RFA

March 2022/by Melissa Machado

The Center for Skeletal Research (CSR), based in the Endocrine Unit at MGH, and funded by the National Institute of Arthritis and Musculoskeletal Diseases (NIAMS) is announcing a request for Pilot and Feasibility Research proposals ($35,000/year; with up to $6,800 in IDC).   This announcement is directed to faculty proposing highly focused Skeletal Biology research projects with the goal of generating preliminary data sufficient to support an application for independent NIH research support (or for a K or K-like career development award for junior faculty). Awardees will be expected to present progress to CSR members biannually and provide a written annual report.  NOTE CHANGES IN ELIGIBILITY CRITERIA BELOW.

LETTER OF INTENT DUE TUESDAY, MARCH 7 AT 5PM EST

Letter of intent should include

  • a 250 word abstract
  • a 150 word statement of eligibility
  • an NIH style biosketch including all other support.

Please submit in a single PDF file to csrmail@partners.org

In the subject line include your last name and “P30P+F LOI”  eg: SmithP30P+F LOI

THOSE INVITED TO APPLY FOR FUNDING WILL BE INFORMED BY MONDAY, MARCH 13.

Applications will be due on April 11 at 5PM EST.

Eligibility is based on the criteria listed below:

  1. Faculty (under NIH investigator criteria) proposing highly focused Skeletal Biology research projects with the goal of generating preliminary data sufficient to support an application for a Career Development Award or for independent NIH research support. Applicants in this group must meet the NIH Early Investigator Criteria(New Investigators who have had less than 10 years of research or research training experience after the completion of their terminal research degree or medical residency, see http://grants.nih.gov/grants/new_investigators/index.htm).
  2. Established researchers from outside the bone field proposing innovative studies relevant to Skeletal Biology.
  3. Established Skeletal Biology investigators proposing studies relevant to Skeletal Biology that represents a clear departure from their established line of investigation.
  4. Recipients of career awards such as K99/R00, K08, K01, etc. or equivalent from other funding agencies

Investigators must invest at least 1 calendar month of effort.  If salary requests do not reflect this effort, cost-sharing plans must be indicated. Applicants who are not U.S. citizens or permanent U.S. residents must have active visas permitting them to remain in the U.S. for the full period of the proposed research.

Per NIAMS rules, interventional clinical studies are not allowed.

Previous P30 P&F awardees will be allowed to re-apply for an additional year of funding.

Note:  click here to access the form for requesting an extension in the Early Stage Investigator (ESI) and Early Established Investigator (EEI) Period.

Click here for downloadable announcement.

Awardees

PI TITLE OF PROJECT
2022
Beth Bragdon, PhD The Effect of Type 2 Diabetes on Skeletal Stem Cell Response to Injury
Fjola Johannesdottir, PhD Influence of Trunk Muscle and Vertebral Bone Deficits on Fracture Risk in Type 1 Diabetes
Tadatoshi Sato, PhD Development of rAAV Gene Therapy for Osteogenesis Imperfecta
2021
Susan MacLauchlan The role of TET2-mediated clonal hematopoiesis in osteoporosis
Brianne Connizzo An In Vivo Model of Inflammation-Based Joint Damage to Study Bone-Tendon Interactions
Nora Renthal Functional genomic screening to expedite gene discovery in growth plate chondrocytes
Petra Simic Glycerol-3-phosphate acyltransferase-2 regulates FGF23 in acute kidney injury
2020
Christian Jacome-Galarza Title Cellular origins and functions of osteoclasts precursors in arthritis
Masao Kaneki Targeting myostatin-activin type 2 receptor pathway prevents burn injury-induced bone loss
Jessica Lehoczky ANCHORING LGR6 TO OSTEOGENESIS
2019
Eva S. Liu, M.D. Role of 1, 25 dihydroxyvitamin D in the development of enthesopathy in X-linked hypophosphatemia
Michael B. Albro, M.S., Ph.D. Targeted Inhibition of Pathogenic TGF-beta Activity in Osteoarthritis
2018
Diana L. Carlone, Ph.D. Cfp1 Action in Chondrogenesis
LI Zeng, Ph.D. The Role of T lymphocytes in Osteoarthritis Progression
2017
Frank Ko, Ph.D. The effects of caloric restriction on bone formation and mTOR signaling
Michaela Reagan, Ph.D. Targeting sclerostin in multiple myeloma-induced bone disease
2016
Keertik Fulzele, Ph.D. Metabolic effect of bone secreted Wnt-signaling inhibitor sclerostin
Marc Wein, M.D., Ph.D. Control of osteocyte biology by salt inducible kinases
2015
(Year 2) Agnes Berendsen, Ph.D. VEGF-dependent control of osteoblast/adipocyte differentiation
Jenna Galloway, Ph.D. A zebrafish model of tendon-bone attachment injury and regeneration
2014
Agnes Berendsen, Ph.D. VEGF-dependent control of osteoblast/adipocyte differentiation
Melissa Putman, M.D. Whole body vibration to prevent the musculoskeletal complications of immobility
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