2024 P30 Pilot & Feasibility Award RFA
The Center for Skeletal Research (CSR), funded by the National Institute of Artritis and Musculoskeletal Diseases (NIAMS), is announcing a request for Pilot and Feasibility Research proposals ($35,000/year) The Awardees will be expected to present progress to CSR members biannually and provide a written annual report. Basic, translational, and clinical studies are welcome, though no clinical trials are allowed. Prior CSR P&F awardees are not eligible.
LETTER OF INTENT DUE TUESDAY, MARCH 25, 2024 AT 5PM EST
Letter of intent should include
- a 250 word abstract
- a 150 word statement of eligibility
- an NIH style biosketch including all other support.
Please submit in a single PDF file to csrmail@partners.org
In the subject line include your last name and “P30P+F LOI” eg: SmithP30P+F LOI
THOSE INVITED TO APPLY FOR FUNDING WILL BE INFORMED BY Monday, April 1, 2024
A three-page scientific proposal will be due on April 19, 2024 at 5PM EST.
Expected funding date (depending on NIH approval) Monday, August 5, 2024
Eligibility is based on the criteria listed below:
- Early career faculty proposing research projects related to musculoskeletal diseases and disorders, with the goal of generating preliminary data sufficient to support an application for independent NIH research support. Applicants in this group must meet the NIH Early Investigator Criteria(e.g, investigators who have had less than 10 years of research or research training experience after the completion of their terminal research degree or residency, see http://grants.nih.gov/grants/new_investigators/index.htm). Awardees of K grants may apply with committed effort but cannot receive salary from the P&F.
- Established investigators from outside the musculoskeletal field proposing innovative studies relevant to musculoskeletal diseases and disorders.
- Established investigators proposing studies relevant to musculoskeletal diseases and disorders that represents a clear departure from their established line of investigation.
Investigators must invest at least 1 calendar month of effort. If salary requests do not reflect this effort, cost-sharing plans must be indicated. Applicants who are not U.S. citizens or permanent U.S. residents must have active visas permitting them to remain in the U.S. for the full period of the proposed research.
Per NIAMS rules, interventional clinical studies are not allowed.
Previous P30 P&F awardees will be allowed to re-apply for an additional year of funding.
Note: click here to access the form for requesting an extension in the Early-Stage Investigator (ESI) and Early Established Investigator (EEI) Period.
Click here for downloadable announcement.
Awardees
PI | TITLE OF PILOT AND FEASIBILITY PROJECT |
2023 | |
Qian Cong, PhD
(HSDM) |
Stem cells and committed muscle cells reprogram in heterotopic ossification dependent of inflammation |
Lamya Karim, PhD
(UMass Dartmouth) |
Impact of irisin on glycation in bone tissue and cells |
David Maridas, PhD
(HSDM) |
The role of Smad1/5/8 signaling in the postnatal skeleton |
2022 | |
Beth Bragdon, PhD
(BUSM, Orth) |
The Effect of Type 2 Diabetes on Skeletal Stem Cell Response to Injury |
Fjola Johannesdottir, PhD
(BIDMC, Orth) |
Influence of Trunk Muscle and Vertebral Bone Deficits on Fracture Risk in Type 1 Diabetes |
Tadatoshi Sato, PhD
(UMass) |
Development of rAAV Gene Therapy for Osteogenesis Imperfecta |
2021 | |
Susan MacLauchlan, PhD
(BWH, Rheum) |
The role of TET2-mediated clonal hematopoiesis in osteoporosis |
Brianne Connizzo, PhD
(BUSM, Engineering) |
An In Vivo Model of Inflammation-Based Joint Damage to Study Bone-Tendon Interactions |
Nora Renthal, MD, PhD
(BCH, Endo) |
Functional genomic screening to expedite gene discovery in growth plate chondrocytes |
Petra Simic, MD, PhD
(MGH, Renal) |
Glycerol-3-phosphate acyltransferase-2 regulates FGF23 in acute kidney injury |
2020 | |
Christian Jacome-Galarza
(BWH, Rheum) |
Title Cellular origins and functions of osteoclasts precursors in arthritis |
Masao Kaneki
(MGH, Pain Med) |
Targeting myostatin-activin type 2 receptor pathway prevents burn injury-induced bone loss |
Jessica Lehoczky
(BWH, Orth) |
ANCHORING LGR6 TO OSTEOGENESIS |
2019 | |
Eva S. Liu, M.D.
(BWH, Endo) |
Role of 1, 25 dihydroxyvitamin D in the development of enthesopathy in X-linked hypophosphatemia |
Michael B. Albro, M.S., Ph.D.
(BUSM, Engineering) |
Targeted Inhibition of Pathogenic TGF-beta Activity in Osteoarthritis |
2018 | |
Diana L. Carlone, Ph.D.
(BCH, Endo) |
Cfp1 Action in Chondrogenesis |
LI Zeng, Ph.D.
(Tufts) |
The Role of T lymphocytes in Osteoarthritis Progression |
2017 | |
Frank Ko, Ph.D.
(MGH, Endo) |
The effects of caloric restriction on bone formation and mTOR signaling |
Michaela Reagan, Ph.D.
(MMCRI) |
Targeting sclerostin in multiple myeloma-induced bone disease |
2016 | |
Keertik Fulzele, Ph.D.
(BUSM, Dental) |
Metabolic effect of bone secreted Wnt-signaling inhibitor sclerostin |
Marc Wein, M.D., Ph.D.
(MGH, Endo) |
Control of osteocyte biology by salt inducible kinases |
2015 | |
(Year 2) Agnes Berendsen, Ph.D.
(HSDM) |
VEGF-dependent control of osteoblast/adipocyte differentiation |
Jenna Galloway, Ph.D.
(MGH, Orth) |
A zebrafish model of tendon-bone attachment injury and regeneration |
2014 | |
Agnes Berendsen, Ph.D.
(HSDM) |
VEGF-dependent control of osteoblast/adipocyte differentiation |
Melissa Putman, M.D.
(BCH, Endo) |
Whole body vibration to prevent the musculoskeletal complications of immobility |