Journal Clubs

Contact CSRmail@partners.org for Journal Club Zoom links.

MGH Endocrine Unit Mineral Metabolism Journal Club

Presenter & Date	Journal Article
Meets on Fridays at 1:00pm. Click here for full schedule.
Dr. Elaine Yu 10/22	Fractures After Denosumab Discontinuation: A Retrospective Study of 797 Cases. Diminishing Value from Multiple Serial Bone Densitometry in Women Receiving Antiresorptive Medication for Osteoporosis Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics Cardiovascular Safety of Denosumab Across Multiple Indications: A Systematic Review and Meta-Analysis of Randomized Trials Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study
Dr. Debbie Mitchell 10/15	Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension. Risk of Subsequent Fractures in Postmenopausal Women After Nontraumatic vs Traumatic Fractures. Obesity-Associated GNAS Mutations and the Melanocortin Pathway.
Dr. Sabashini Ramchand 9/24	Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX®, Falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study: A Meta-Analysis Prior loss of body mass index, low body mass index, and central obesity independently contribute to higher rates of fractures in elderly women and men. The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial Using HR-pQCT Patient Outcomes in the Years After a DXA-BMD Treatment Monitoring Test: Improved Medication Adherence in Some, But Too Little Too Late
Dr. Ben Leder 9/17	Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT. Beyond Bone Mineral Density: A New Dual X-Ray Absorptiometry Index of Bone Strength to Predict Fragility Fractures, the Bone Strain Index. Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women. DXA-Based Bone Strain Index: A New Tool to Evaluate Bone Quality in Primary Hyperparathyroidism.
Dr. Harald Jüppner 5/28	Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans. Non-oxidized parathyroid hormone (PTH) measured by current method is not superior to total PTH in assessing bone turnover in chronic kidney disease. Phosphate meeting cholesterol—consequences for cardiovascular disease in chronic kidney disease?. Parathyroid hormone oxidation in chronic kidney disease: clinical relevance?
Dr. Debbie Mitchell 5/21	Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children. Vitamin D for Growth and Rickets in Stunted Children: A Randomized Trial. Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
Dr. Marie Demay 5/7	Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism. Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women. Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes.
Dr. Joy Tsai 4/30	Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized PlaceboControlled Trial. Early Effects of Abaloparatide on Bone Formation and Resorption Indices in Postmenopausal Women With Osteoporosis. Burosumab for the Treatment of Tumor-Induced Osteomalacia.

MGH Endocrine Unit Gene Regulation and Development Journal Club

Presenter & Date	Journal Article (click to view)
Meets on Tuesdays at 10:45 am
Dr. Margaret Kobelski 5/25	Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Dr. Tatsuya Kobayashi 5/18	Cell-programmed nutrient partitioning in the tumour microenvironment.
Dr. Christopher Janton 4/27	Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Dr. Lauren Surface 4/20	Actin cables and comet tails organize mitochondrial networks in mitosis.

MGH Endocrine Unit Signaling Journal Club

Presenter & Date	Journal Article (click to view)
Meets on Wednesdays at 3:00 pm
Monica Reyes 11/10	Pseudohypoparathyroidism Type 1b Locus Is Linked to a Region Including GNAS1 at 20q13.3 ( 2003 paper).
Dr. Yorihiro Iwasaki 10/20	Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta.
Dr. Wen Zhou 9/22	Role of the Sodium-Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Cell Calcification. Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofber function and survival.
Dr. Patrick Hanna 5/5	Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects.
Dr. Murat Bastepe 4/21	Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.

News

NEW: Directed Differentiation Core ServicesJanuary 2023 - 10:11 am
PI: April Craft, PhD Assistant Professor of Orthopedic Surgery, BCH, HMS; Affiliate Faculty, Stem Cells & Regenerative Biology; Principal Faculty, Harvard Stem Cell Institute; Co-Director, Musculoskeletal Disease Program, HSCI Email: april.craft@childrens.harvard.edu […]
NEW CORE: Arthritis and Joint Structure CoreJanuary 2023 - 3:57 pm
Innovation Award for use of new Arthritis and Joint Structure Core Click Here to access the application. Email filled out applications to CSRmail@partners.org. This award will provide up to $5000 […]
CSR Mentee Survey for CSR TraineesNovember 2022 - 12:12 pm
Northeastern University Open Rank: Assistant/Associate/Professor – Healthy Aging, Department of BiologyOctober 2022 - 3:31 pm
Click Here for the application link and the job description