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Journal Clubs

Contact CSRmail@partners.org for Journal Club Zoom links.

MGH Endocrine Unit Mineral Metabolism Journal Club

Presenter & Date Journal Article
Meets on Fridays at 1:00pm.  Click here for full schedule.
Dr. Elaine Yu

10/22

  • Fractures After Denosumab Discontinuation: A Retrospective Study of 797 Cases.
  • Diminishing Value from Multiple Serial Bone Densitometry in Women Receiving Antiresorptive Medication for Osteoporosis
  • Evaluating the cardiovascular safety of sclerostin inhibition using evidence from meta-analysis of clinical trials and human genetics
  • Cardiovascular Safety of Denosumab Across Multiple Indications: A Systematic Review and Meta-Analysis of Randomized Trials
  • Simulated effects of early menopausal bone mineral density preservation on long-term fracture risk: a feasibility study
Dr. Debbie Mitchell

10/15

  • Burosumab treatment in adults with X-linked hypophosphataemia: 96-week patient-reported outcomes and ambulatory function from a randomised phase 3 trial and open-label extension.
  • Risk of Subsequent Fractures in Postmenopausal Women After Nontraumatic vs Traumatic Fractures.
  • Obesity-Associated GNAS Mutations and the Melanocortin Pathway.
Dr. Sabashini Ramchand

9/24

  • Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAX®, Falls, and BMD in the Osteoporotic Fractures in Men (MrOS) Study: A Meta-Analysis
  • Prior loss of body mass index, low body mass index, and central obesity independently contribute to higher rates of fractures in elderly women and men.
  • The Effect of Bolus Vitamin D3 Supplementation on Distal Radius Fracture Healing: A Randomized Controlled Trial Using HR-pQCT

  • Patient Outcomes in the Years After a DXA-BMD Treatment Monitoring Test: Improved Medication Adherence in Some, But Too Little Too Late

Dr. Ben Leder

9/17

  • Effect of Testosterone Treatment on Bone Microarchitecture and Bone Mineral Density in Men: A 2-Year RCT.
  • Beyond Bone Mineral Density: A New Dual X-Ray Absorptiometry Index of Bone Strength to Predict Fragility Fractures, the Bone Strain Index.
  • Urinary Phthalate Biomarkers and Bone Mineral Density in Postmenopausal Women.
  • DXA-Based Bone Strain Index: A New Tool to Evaluate Bone Quality in Primary Hyperparathyroidism.
Dr. Harald Jüppner

5/28

  • Hyperphosphatemia in chronic kidney disease exacerbates atherosclerosis via a mannosidases-mediated complex-type conversion of SCAP N-glycans.
  • Non-oxidized parathyroid hormone (PTH) measured by current method is not superior to total PTH in assessing bone turnover in chronic kidney disease.
  • Phosphate meeting cholesterol—consequences for cardiovascular disease in chronic kidney disease?.
  • Parathyroid hormone oxidation in chronic kidney disease: clinical relevance?
Dr. Debbie Mitchell

5/21

  • Hepatic Steatosis is Negatively Associated with Bone Mineral Density in Children.
  • Vitamin D for Growth and Rickets in Stunted Children: A Randomized Trial.
  • Vitamin D supplementation to prevent acute respiratory infections: a systematic review and meta-analysis of aggregate data from randomised controlled trials.
Dr. Marie Demay

5/7

  • Vertebral Fracture Assessment in Postmenopausal Women With Postsurgical Hypoparathyroidism.
  • Long-term Bone Loss and Deterioration of Microarchitecture After Gastric Bypass in African American and Latina Women.
  • Investigation of Mechanical, Material, and Compositional Determinants of Human Trabecular Bone Quality in Type 2 Diabetes.
Dr. Joy Tsai

4/30

  • Effect of Low-Intensity Vibration on Bone Strength, Microstructure, and Adiposity in Pre-Osteoporotic Postmenopausal Women: A Randomized PlaceboControlled Trial.
  • Early Effects of Abaloparatide on Bone Formation and Resorption Indices in Postmenopausal Women With Osteoporosis.
  • Burosumab for the Treatment of Tumor-Induced Osteomalacia.

MGH Endocrine Unit Gene Regulation and Development Journal Club

Presenter & Date Journal Article (click to view)
Meets on Tuesdays at 10:45 am
Dr. Margaret Kobelski

5/25

Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset
Dr. Tatsuya Kobayashi

5/18

Cell-programmed nutrient partitioning in the tumour microenvironment.
Dr. Christopher Janton

4/27

Gasdermin D pore structure reveals preferential release of mature interleukin-1.
Dr. Lauren Surface

4/20

Actin cables and comet tails organize mitochondrial networks in mitosis.

MGH Endocrine Unit Signaling Journal Club

Presenter & Date Journal Article (click to view)
Meets on Wednesdays at 3:00 pm
Monica Reyes

11/10

Pseudohypoparathyroidism Type 1b Locus Is Linked to a Region Including GNAS1 at 20q13.3 ( 2003 paper).
Dr. Yorihiro Iwasaki

10/20

Analysis of developmental imprinting dynamics in primates using SNP-free methods to identify imprinting defects in cloned placenta.

Dr. Wen Zhou

9/22

Role of the Sodium-Dependent Phosphate Cotransporter, Pit-1, in Vascular Smooth Muscle Cell Calcification.

Slc20a1/Pit1 and Slc20a2/Pit2 are essential for normal skeletal myofber function and survival.

Dr. Patrick Hanna

5/5

Furin Inhibitors Block SARS-CoV-2 Spike Protein Cleavage to Suppress Virus Production and Cytopathic Effects.
Dr. Murat Bastepe

4/21

Orphan nuclear receptor ERR-γ regulates hepatic FGF23 production in acute kidney injury.

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Center for Skeletal Research
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