Core overview: Translational Imaging and Biomechanics core is focused on bridging the basic science findings to clinical observations though imaging and biomechanical assessments to assist with studying the disease mechanism, biomarkers, and treatments for a range of skeletal disorders. The core offers a diverse range of services including: 1) Quantitative imaging to assess joint morphology and tissue structural properties 2) Experimental and computational evaluation of tissue mechanical properties 3) Clinical cohort identification (e.g., patients with certain musculoskeletal disorders) and phenotype matching to build multi-center database of imaging, clinical and genomics data to help better interpret and validate the preclinical observations 1) Quantitative imaging to assess joint morphology and tissue structural properties 2) Experimental and computational evaluation of tissue mechanical properties 3) Clinical cohort identification (e.g., patients with certain musculoskeletal disorders) to build multi-center database of imaging, clinical and genomics data to help better interpret and validate the preclinical observations